Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Saroop S. Matharu"'
Autor:
Phillip L. Evans, Saroop S. Matharu, Scott A. Raybuck, David Kay, Yu-Ping Luong, Lauffer David J, Murcko Mark A, David J. Livingston, Mullican Michael D, Golec Julian M C, Roger John Gillespie, Geoffrey M. Porritt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2359-2364
The tetrapeptide aldehyde Ac-Tyr-Val-Ala-AspH ( 1 , L-709,049) has been reported to be a potent reversible inhibitor of Interleukin-1β Converting Enzyme (ICE). We have prepared a series of analogs of 1 , in order to explore the active sige of ICE. T
Autor:
C. B. Jones, E. A. Kuo, Yea Christopher Martyn, C. J. R. Hedgecock, Peter W. Hairsine, N. Mcdowall, R. A. Williamson, P. Hambleton, W. R. Tully, Robert Westwood, Saroop S. Matharu, Ian R. Ager, David Kay, A. W. E. Chan, P. L. Evans, E. Little
Publikováno v:
Journal of medicinal chemistry. 39(23)
The active metabolite (2) of the novel immunosuppressive agent leflunomide (1) has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. A series of analogues
Publikováno v:
Journal of Medicinal Chemistry. 22:418-424
The antiallergic activity of some xanthone derivatives containing a sulfoximide substitutent has been investigated. While 2-(S-methylsulfonimidoyl)xanthone itself was found to be inactive, a series of 7-(S-methylsulfonimidoly)-xanthone-2-carboxylic a
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :2542-2548
The synthesis of (±)-cis- and (±)-trans-4-isopropenylpyrrolidin-3-ylacetic acids and the attempted synthesis of (±)-2,3-trans-,3,4-cis-2-carboxy-4-isopropenylpyrrolidin-3-ylacetic acid, α-kainic acid, by intramolecular ene reactions are described
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :2553-2562
The syntheses of cis- and trans-2-aminocyclopropyl, -cyclobutyl, -cyclopentyl, and -cyclohexylacetic acids as γ-aminobutyric acid analogues of restricted conformation are described. Mass spectral evidence fully supports the stereochemical assignment
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :2563-2570
The syntheses of analogues with restricted rotation about the C(2)–C(3) bond of γ-aminobutyric acid, namely cisand trans-2-(aminomethyl)-cyclopropane and -cyclobutanecarboxylic acids and trans-2-(aminomethyl)cyclohexanecarboxylic acid are describe
Autor:
G. W. Danswan, I. R. Ager, Peter A. Robson, Alan Charles Barnes, Saroop S. Matharu, P. D. Kennewell, D. P. Kay, David Alun Rowlands, P. W. Hairsine, R. Westwolld, P. Miller, W. R. Tully
Publikováno v:
ChemInform. 19
Autor:
S. Clements-Jewery, R. Murdoch, W. R. Tully, Saroop S. Matharu, Robert Westwood, G. W. Danswan, Colin R. Gardner
Publikováno v:
ChemInform. 19
Several series of heterocyclic carboxylic esters were found to be active in the benzodiazepine receptor binding assay, a typical example being ethyl 7-ethyl-5-methoxyimidazo[1,2-a]quinoline-2-carboxylate (4b) with an IC50 of 150 nM. The corresponding
Publikováno v:
Chemischer Informationsdienst. 8
The synthesis of a novel series of antitussive agents is described. Two series of amino-substituted tetra- and hexahydrodibenzofurans were prepared and examined for antitussive activity in the guinea pig after cough elicited by electrical stimulation
Publikováno v:
Chemischer Informationsdienst. 10