Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Saroja, Ramanujan"'
Digital twins elucidate critical role of Tscm in clinical persistence of TCR-engineered cell therapy
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Despite recent progress in adoptive T cell therapy for cancer, understanding and predicting the kinetics of infused T cells remains a challenge. Multiple factors can impact the distribution, expansion, and decay or persistence of infused T c
Externí odkaz:
https://doaj.org/article/3a87a9a0cb4f4227b3ae4c85f13adb9b
Autor:
Monica E. Susilo, Chi‐Chung Li, Kapil Gadkar, Genevive Hernandez, Ling‐Yuh Huw, Jin Y. Jin, Shen Yin, Michael C. Wei, Saroja Ramanujan, Iraj Hosseini
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 7, Pp 1134-1148 (2023)
Abstract Phase I oncology clinical trials often comprise a limited number of patients representing different disease subtypes who are divided into cohorts receiving treatment(s) at different dosing levels and schedules. Here, we leverage a previously
Externí odkaz:
https://doaj.org/article/2bc7d8bf72c444f492e191b7c0cbf612
Autor:
Sharon M. Rymut, Lindsay M. Henderson, Victor Poon, Tracy L. Staton, Fang Cai, Siddharth Sukumaran, Horace Rhee, Ryan Owen, Saroja Ramanujan, Kenta Yoshida
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 4, Pp 694-703 (2023)
Abstract Tryptase, a protease implicated in asthma pathology, is secreted from mast cells upon activation during an inflammatory allergic response. MTPS9579A is a novel monoclonal antibody that inhibits tryptase activity by irreversibly dissociating
Externí odkaz:
https://doaj.org/article/9f61ef52477747f58a911a9bf124e120
Autor:
Iraj Hosseini, Brett Fleisher, Jennifer Getz, Jérémie Decalf, Mandy Kwong, Meric Ovacik, Travis W. Bainbridge, Christine Moussion, Gautham K. Rao, Kapil Gadkar, Amrita V. Kamath, Saroja Ramanujan
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 660 (2024)
FLT3L-Fc is a half-life extended, effectorless Fc-fusion of the native human FLT3-ligand. In cynomolgus monkeys, treatment with FLT3L-Fc leads to a complex pharmacokinetic/pharmacodynamic (PK/PD) relationship, with observed nonlinear PK and expansion
Externí odkaz:
https://doaj.org/article/2aeee9c733c94287888bd277150996d7
Autor:
Vidya Ramakrishnan, Christina Friedrich, Colleen Witt, Robert Sheehan, Meghan Pryor, Jasvinder K. Atwal, Kristin Wildsmith, Katherine Kudrycki, Seung‐Hye Lee, Norman Mazer, Carsten Hofmann, Reina N. Fuji, Jin Y. Jin, Saroja Ramanujan, Michael Dolton, Angelica Quartino
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 1, Pp 62-73 (2023)
Abstract Despite considerable investment into potential therapeutic approaches for Alzheimer's disease (AD), currently approved treatment options are limited. Predictive modeling using quantitative systems pharmacology (QSP) can be used to guide the
Externí odkaz:
https://doaj.org/article/6c9f800424f0462f8528114142c69f0a
Autor:
Kapil Gadkar, Justin Feigelman, Siddharth Sukumaran, Manoj C. Rodrigo, Tracy Staton, Fang Cai, Rebecca N. Bauer, David F. Choy, Cynthia L. Stokes, Heleen Scheerens, Saroja Ramanujan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 9, Pp 1268-1277 (2022)
Abstract Asthma is a complex, heterogeneous disease with a high unmet medical need, despite therapies targeting a multitude of pathways. The ability to quantitatively integrate preclinical and clinical data on these pathways could aid in the developm
Externí odkaz:
https://doaj.org/article/d4c73fd7fc9c4dc591d8ab594626b323
Autor:
Kapil Gadkar, Christina Friedrich, Vincent Hurez, Maria‐Luisa Ruiz, Leslie Dickmann, Mohit Kumar Jolly, Leah Schutt, Jin Jin, Joseph A. Ware, Saroja Ramanujan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 5, Pp 616-627 (2022)
Abstract Several PI3K inhibitors are in clinical development for the treatment of various forms of cancers, including pan‐PI3K inhibitors targeting all four PI3K isoforms (α, β, γ, and δ), and isoform‐selective inhibitors. Diarrhea and immune
Externí odkaz:
https://doaj.org/article/4d3f8999655d4cd4aa9f1a6f87ba8b9e
Autor:
Anna Kondic, Dean Bottino, John Harrold, Jeffrey D. Kearns, CJ Musante, Aleksandrs Odinecs, Saroja Ramanujan, Jangir Selimkhanov, Birgit Schoeberl
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform various decision points from discovery to First-In-Human clinical trials. The article is divided
Externí odkaz:
https://doaj.org/article/cc2e644a24a548b9a118216b30197d39
Autor:
Iraj Hosseini, Justin Feigelman, Anita Gajjala, Monica Susilo, Vidya Ramakrishnan, Saroja Ramanujan, Kapil Gadkar
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 3, Pp 165-176 (2020)
Quantitative systems pharmacology (QSP) models are often implemented using a wide variety of technical workflows and methodologies. To facilitate reproducibility, transparency, portability, and reuse for QSP models, we have developed gQSPSim, a graph
Externí odkaz:
https://doaj.org/article/add1386aea8a43a7a880d7a7032a4a8d
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 340-343 (2019)
Externí odkaz:
https://doaj.org/article/95157eae33704c0da3564f6c60dfa101