Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Saroj K. Rout"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Amyloids may have played an important role in prebiotic molecular evolution but understanding replication of such information-coding molecules is still a problem. Here the authors design a model amyloid substrate and demonstrate sequence regio- and s
Externí odkaz:
https://doaj.org/article/f4617bced55d408e84bbb721d41321de
Autor:
Fabio Lima, Thomas Bein, Derya Bessinger, Cara E. Brocklehurst, Saroj K. Rout, Konstantin Karaghiosoff, Kuno Schwärzer, Paul Knochel
Publikováno v:
Chemical Science. 12:12993-13000
We report the selective functionalization of the 1H-imidazo[1,2-b]pyrazole scaffold using a Br/Mg-exchange, as well as regioselective magnesiations and zincations with TMP-bases (TMP = 2,2,6,6-tetramethylpiperidyl), followed by trapping reactions wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6523bfe9d83798490e49eb930c2ab64c
https://doi.org/10.1039/d1sc04155j
https://doi.org/10.1039/d1sc04155j
Publikováno v:
Chemistry – A European Journal. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::165fe0b1ef92a79c835db67b95133270
https://doi.org/10.1002/chem.202104546
https://doi.org/10.1002/chem.202104546
Publikováno v:
Chemistry-A European Journal, 28 (3)
The prebiotic emergence of molecules capable of both self-replication and of storing information was a defining event at the dawn of life. Still, a plausibly prebiotic self-replication of biologically relevant molecules has not been demonstrated. Bui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4d218db4d524fdcb7d65b2b95c0a6f
https://doi.org/10.1002/chem.202103841
https://doi.org/10.1002/chem.202103841
Autor:
Kuno, Schwärzer, Saroj K, Rout, Derya, Bessinger, Fabio, Lima, Cara E, Brocklehurst, Konstantin, Karaghiosoff, Thomas, Bein, Paul, Knochel
Publikováno v:
Chemical Science
We report the selective functionalization of the 1H-imidazo[1,2-b]pyrazole scaffold using a Br/Mg-exchange, as well as regioselective magnesiations and zincations with TMP-bases (TMP = 2,2,6,6-tetramethylpiperidyl), followed by trapping reactions wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ed342cf0f871927b9188d3278969669
https://pubmed.ncbi.nlm.nih.gov/34745530
https://pubmed.ncbi.nlm.nih.gov/34745530
Autor:
Matthias Bütikofer, Roland Riek, Saroj K. Rout, Radoslaw Bomba, Witek Kwiatkowski, Jason Greenwald
Publikováno v:
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 49(4)
Prebiotic chemical replication is a commonly assumed precursor to and prerequisite for life and as such is the one of the goals of our research. We have previously reported on the role that short peptide amyloids could have played in a template-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893952c289c2427726a5e9abdc2f816c
https://pubmed.ncbi.nlm.nih.gov/31845164
https://pubmed.ncbi.nlm.nih.gov/31845164
Autor:
Vipin Agarwal, Rakesh Kumar, Subhadeep Das, Samir K. Maji, Surabhi Mehra, Narendra Nath Jha, Ganesh M. Mohite, Saayak Halder, Soumik Ray, Saroj K. Rout
Publikováno v:
Angewandte Chemie (International ed. in English). 57(19)
α-Synuclein (α-Syn) aggregation is associated with Parkinson's disease (PD) pathogenesis. In PD, the role of oligomers versus fibrils in neuronal cell death is debatable, but recent studies suggest oligomers are a proximate neurotoxin. Herein, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49eff0f907c7115bce4acd5f26b86c7b
https://pubmed.ncbi.nlm.nih.gov/29524323
https://pubmed.ncbi.nlm.nih.gov/29524323