Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Sarmistha Mukherjee"'
Autor:
Lauren M. Paolella, Sarmistha Mukherjee, Cassie M. Tran, Bruna Bellaver, Mindy Hugo, Timothy S. Luongo, Swapnil V. Shewale, Wenyun Lu, Karthikeyani Chellappa, Joseph A. Baur
Publikováno v:
Molecular Metabolism, Vol 32, Iss , Pp 136-147 (2020)
Objective: Pharmacological agents targeting the mTOR complexes are used clinically as immunosuppressants and anticancer agents and can extend the lifespan of model organisms. An undesirable side effect of these drugs is hyperlipidemia. Although multi
Externí odkaz:
https://doaj.org/article/b5faee1960844042ab6ab3295bfd6258
Autor:
Sarmistha Mukherjee, James Mo, Lauren M. Paolella, Caroline E. Perry, Jade Toth, Mindy M. Hugo, Qingwei Chu, Qian Tong, Karthikeyani Chellappa, Joseph A. Baur
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
Liver regeneration is critical to survival after traumatic injuries, exposure to hepatotoxins, or surgical interventions, yet the underlying signaling and metabolic pathways remain unclear. In this study, we show that hepatocyte-specific loss of the
Externí odkaz:
https://doaj.org/article/5be476c9f2ad4f45a959b3a77c5bb5e1
Autor:
Prasanna M Chandramouleeswaran, Manti Guha, Masataka Shimonosono, Kelly A Whelan, Hisatsugu Maekawa, Uma M Sachdeva, Gordon Ruthel, Sarmistha Mukherjee, Noah Engel, Michael V Gonzalez, James Garifallou, Shinya Ohashi, Andres J Klein-Szanto, Clementina A Mesaros, Ian A Blair, Renata Pellegrino da Silva, Hakon Hakonarson, Eishi Noguchi, Joseph A Baur, Hiroshi Nakagawa
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While
Externí odkaz:
https://doaj.org/article/5a4df4b8798b4fd795ef2f8d80b295c8
Autor:
Tomohito Doke, Sarmistha Mukherjee, Dhanunjay Mukhi, Poonam Dhillon, Amin Abedini, James G. Davis, Karthikeyani Chellappa, Beishan Chen, Joseph A. Baur, Katalin Susztak
Publikováno v:
Nature Metabolism. 5:414-430
Publikováno v:
Journal of Hepatology. 77:S742-S743
Autor:
Qingwei Chu, L. Ji, Joshua D. Rabinowitz, Sarmistha Mukherjee, Wei Lu, Christoph A. Thaiss, Faisal Hayat, Mikhail V. Makarov, K. Chellappa, T. Cox, Joseph A. Baur, Marie E. Migaud, Shawn M. Davidson, Yashaswini R. Bhat, Connor Jankowski, R. T. Shima, Melanie R. McReynolds, Xianfeng Zeng, S. R. Lingala, Hélène Descamps
Publikováno v:
Cell Metabolism. 34:1947-1959.e5
Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor in both mammals and microbes. Here we use isotope tracing to investigate the precursors supporting NAD synthesis in the gut microbiome. We find that preferred dietary NAD precurso
Autor:
Jade Toth, Sarmistha Mukherjee, Karthikeyani Chellappa, Qingwei Chu, James Mo, Caroline Perry, Lauren M Paolella, Joseph A. Baur, Mindy M Hugo, Qiang Tong
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 7 (2021)
JCI Insight, Vol 6, Iss 7 (2021)
Liver regeneration is critical to survival after traumatic injuries, exposure to hepatotoxins, or surgical interventions, yet the underlying signaling and metabolic pathways remain unclear. In this study, we show that hepatocyte-specific loss of the
Autor:
Vera Gorbunova, Marcus Buschbeck, Xiaolu A. Cambronne, Karthikeyani Chellappa, Daniela Corda, Juan Du, Marc Freichel, Jonathan Gigas, Alexander E. Green, Feng Gu, Iva Guberovic, Aravinthkumar Jayabalan, Imrankhan Khansahib, Sarmistha Mukherjee, Andrei Seluanov, Matthew A. Simon, Lars J. Sverkeli, Nora Kory, Daniel C. Levine, Ivan Matic, Andrey Nikiforov, Johannes G.M. Rack, Shin-Ichiro Imai, David A. Sinclair, Debra Toiber, Yongjuan Zhao, Raul Mostoslavsky, Lee Kraus, Andreas H. Guse
Publikováno v:
Aging
24924-24930
Aging (Albany NY)
24924-24930
Aging (Albany NY)
publishedVersion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c814ae682be5b29ae943a03cd6518b9
https://hdl.handle.net/11250/2988883
https://hdl.handle.net/11250/2988883
Autor:
Li Chen, Sarmistha Mukherjee, Qingwei Chu, Wenyun Lu, Connor Jankowski, Joshua D. Rabinowitz, Cristoph Thaiss, Melanie R. McReynolds, Eric Chiles, Paul Botolin, Xiaoyang Su, Karthikeyani Chellappa, Joseph A. Baur, Hélène Descamps, Yishui Shen, Yashaswini R. Bhat
NAD+ is an essential coenzyme found in all living cells. NAD+ concentrations decline during aging, but whether this reflects impaired production or accelerated consumption remains unclear. Here we employed isotope tracing and mass spectrometry to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d7de65c62a578f6f605a34649df4503
https://doi.org/10.21203/rs.3.rs-86538/v1
https://doi.org/10.21203/rs.3.rs-86538/v1
Autor:
Marie E. Migaud, Yashaswini R. Bhat, Paul Botolin, Qingwei Chu, Katalin Susztak, Xiaoyang Su, Joseph A. Baur, Yihui Shen, Melanie R. McReynolds, Li Chen, Tomohito Doke, Eric Chiles, Karthikeyani Chellappa, Christoph A. Thaiss, Connor Jankowski, Faisal Hayat, Wenyun Lu, Hélène Descamps, Siddharth R. Lingala, Joshua D. Rabinowitz, Sarmistha Mukherjee
Publikováno v:
Cell Syst
NAD(+) is an essential coenzyme for all living cells. NAD(+) concentrations decline with age, but whether this reflects impaired production or accelerated consumption remains unclear. We employed isotope tracing and mass spectrometry to probe age-rel