Merkel Cell Carcinoma: Investigations on its carcinogenesis and new therapeutic approaches

Autor: Sarma, Bhavishya

Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with an increasing incidence. The majority of MCC cases (approximately 80%) are associated with the Merkel cell polyomavirus (MCPyV). This virus encodes for the MCPyV T antigens (small

Externí odkaz: https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/24740
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-247402
https://opus.bibliothek.uni-wuerzburg.de/files/24740/PhD_Thesis_Bhavishya_Sarma.pdf

Polyomavirus-Positive Merkel Cell Carcinoma Derived from a Trichoblastoma Suggests an Epithelial Origin of this Merkel Cell Carcinoma

Autor: Kervarrec, Thibault, Aljundi, Mohanad, Appenzeller, Silke, Samimi, Mahtab, Maubec, Eve, Cribier, Bernard, Deschamps, Lydia, Sarma, Bhavishya, Sarosi, Eva-Maria, Berthon, Patricia, Levy, Annie, Bousquet, Guilhem, Tallet, Anne, Touzé, Antoine, Guyétant, Serge, Schrama, David, Houben, Roland

Publikováno v: In Journal of Investigative Dermatology May 2020 140(5):976-985

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Merkel cell polyomavirus T antigens induce Merkel cell-like differentiation in GLI1-expressing epithelial cells

Autor: Kervarrec, Thibault, Samimi, Mahtab, Hesbacher, Sonja, Berthon, Patricia, Wobser, Marion, Sallot, Aurélie, Sarma, Bhavishya, Schweinitzer, Sophie, Gandon, Théo, Destrieux, Christophe, Pasqualin, Côme, Guyétant, Serge, Touzé, Antoine, Houben, Roland, Schrama, David

Publikováno v: Cancers
Cancers, MDPI, 2020, 12 (7), 20 p. ⟨10.3390/cancers12071989⟩
Cancers, Vol 12, Iss 1989, p 1989 (2020)
Volume 12
Issue 7

Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by the Merkel cell polyomavirus (MCPyV). It is still under discussion, in which cells viral integration and MCC development occurs. Recently, we demonstrated that a virus-posi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ac8a5cf48126f48c94cf416b57f92c9b
https://hal.inrae.fr/hal-02951400/document

Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review

Autor: Kervarrec, Thibault, Samimi, Mahtab, Guyétant, Serge, Sarma, Bhavishya, Chéret, Jeremy, Blanchard, Emmanuelle, Berthon, Patricia, Schrama, David, Houben, Roland, Touzé, Antoine

Publikováno v: Frontiers in Oncology
Frontiers in Oncology, Frontiers, 2019, 9, 13 p. ⟨10.3389/fonc.2019.00451⟩
Frontiers in Oncology, 2019, 9, 13 p. ⟨10.3389/fonc.2019.00451⟩

International audience; Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin. This neoplasia features aggressive behavior, resulting in a 5-year overall survival rate of 40%. In 2008, Feng et al. identified Merkel cell polyom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::475e932f30e7eed96f893c55961e34c0
https://hal.inrae.fr/hal-02621855