Characterization and standardization of multiassay platforms for four commonly studied traumatic brain injury protein biomarkers: a TBI Endpoints Development Study

Autor: Sarkis, George Anis, Zhu, Tian, Yang, Zhihui, Li, Xue, Shi, Yuan, Rubenstein, Richard, Yost, Richard A, Manley, Geoffrey T, Wang, Kevin K

Publikováno v: Biomarkers in medicine, vol 15, iss 18

Aim: There is a critical need to validate biofluid-based biomarkers as diagnostic and drug development tools for traumatic brain injury (TBI). As part of the TBI Endpoints Development Initiative, we identified four potentially predictive and pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::7b070a5eb5b814bdba22996327aabc61
https://escholarship.org/uc/item/40z968sk

Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid

Autor: Boutté, Angela M, Hook, Vivian, Thangavelu, Bharani, Sarkis, George Anis, Abbatiello, Brittany N, Hook, Gregory, Jacobsen, J Steven, Robertson, Claudia S, Gilsdorf, Janice, Yang, Zhihui, Wang, Kevin KW, Shear, Deborah A

Publikováno v: Journal of neurotrauma, vol 37, iss 13

Cathepsin B (CatB), a lysosomal cysteine protease, is important to brain function and may have dual utility as a peripheral biomarker of moderate-severe traumatic brain injury (TBI). The present study determined levels of pro- and mature (mat) CatB p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d91bec013790b00ea3bf6c908b9a628d
https://escholarship.org/uc/item/8384f0bb

Generation and Release of Neurogranin, Vimentin, and MBP Proteolytic Peptides, Following Traumatic Brain Injury.

Autor: Sarkis, George Anis, Lees-Gayed, Nicholas, Banoub, Joseph, Abbatielo, Susan E., Robertson, Claudia, Haskins, William E., Yost, Richard A., Wang, Kevin K. W.

Publikováno v: Molecular Neurobiology; Feb2022, Vol. 59 Issue 2, p731-747, 17p

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Characterization and standardization of multiassay platforms for four commonly studied traumatic brain injury protein biomarkers: a TBI Endpoints Development Study.

Autor: Sarkis GA; Department of Chemistry, University of Florida, Gainesville, FL 32611, USA., Zhu T; Department of Emergency Medicine, University of Florida, 1149 Newell Drive, L4-100, Gainesville, FL 32611, USA.; Department of Pediatrics, Daping Hospital, Chongqing, Third Military Medical University, Chongqing, China.; Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China., Yang Z; Department of Emergency Medicine, University of Florida, 1149 Newell Drive, L4-100, Gainesville, FL 32611, USA., Li X; Department of Emergency Medicine, University of Florida, 1149 Newell Drive, L4-100, Gainesville, FL 32611, USA.; Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China., Shi Y; Department of Pediatrics, Daping Hospital, Chongqing, Third Military Medical University, Chongqing, China.; Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China., Rubenstein R; Department of Neurology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203-2098, USA., Yost RA; Department of Chemistry, University of Florida, Gainesville, FL 32611, USA., Manley GT; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA., Wang KK; Department of Emergency Medicine, University of Florida, 1149 Newell Drive, L4-100, Gainesville, FL 32611, USA.; Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, North Florida/South Georgia Veterans Health System, 1601 SW Archer Road, Gainesville, FL 32608, USA.

Publikováno v: Biomarkers in medicine [Biomark Med] 2021 Dec; Vol. 15 (18), pp. 1721-1732. Date of Electronic Publication: 2021 Oct 22.