Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts.

Autor: Ji J; Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China., Dragojevic S; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Callaghan CM; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Smith EJ; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Talele S; Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota., Zhang W; Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota., Connors MA; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Mladek AC; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Hu Z; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Bakken KK; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Sarkaria PP; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Carlson BL; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Burgenske DM; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Decker PA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota., Rashid MA; RWJ-Neurosurgery, Rutgers, The State University of New Jersey, New Brunswick, New Jersey., Jang MH; RWJ-Neurosurgery, Rutgers, The State University of New Jersey, New Brunswick, New Jersey., Gupta SK; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Eckel-Passow JE; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota., Elmquist WF; Brain Barriers Research Center, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota., Sarkaria JN; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2024 May 02; Vol. 23 (5), pp. 662-671.