Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sarju J. Patel"'
Autor:
Sarju J. Patel, Olga Protchenko, Caroline C. Philpott, Minoo Shakoury-Elizeh, Shyamalagauri Jadhav, Ethan Baratz
Publikováno v:
Proc Natl Acad Sci U S A
Poly(rC)-binding protein (PCBP1) is a multifunctional adaptor protein that can coordinate single-stranded nucleic acids and iron-glutathione complexes, altering the processing and transfer of these ligands through interactions with other proteins. Mu
Management versus miscues in the cytosolic labile iron pool: The varied functions of iron chaperones
Publikováno v:
Biochim Biophys Acta Mol Cell Res
Iron-containing proteins rely on the incorporation of a set of iron cofactors for activity. The cofactors must be synthesized or assembled from raw materials located within the cell. The chemical nature of this pool of raw material - referred to as t
Autor:
Georgy K. Vladimirov, Tamil S. Anthonymuthu, Valerian E. Kagan, Yulia Y. Tyurina, Caroline C. Philpott, Hülya Bayır, Qin Yang, Sarju J. Patel, Andrew M. Lamade, Andrew A. Amoscato
Publikováno v:
Cell Chem Biol
Redox balance is essential for normal brain, hence dis-coordinated oxidative reactions leading to neuronal death, including programs of regulated death, are commonly viewed as an inevitable pathogenic penalty for acute neuro-injury and neurodegenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2b5eb6b71404057a4200049379c751
https://europepmc.org/articles/PMC7218794/
https://europepmc.org/articles/PMC7218794/
Publikováno v:
Journal of Biological Chemistry. 292:12764-12771
Eukaryotic cells contain hundreds of metalloproteins that are supported by intracellular systems coordinating the uptake and distribution of metal cofactors. Iron cofactors include heme, iron-sulfur clusters, and simple iron ions. Poly(rC)-binding pr
Autor:
Brianne E. Lewis, Timothy L. Stemmler, José M. Argüello, Christopher M. Sassetti, Subhalaxmi Nambi, Sarju J. Patel, Jarukit E. Long
Publikováno v:
Journal of Biological Chemistry. 291:11529-11539
Little is known about iron efflux transporters within bacterial systems. Recently, the participation of Bacillus subtilis PfeT, a P1B4-ATPase, in cytoplasmic Fe(2+) efflux has been proposed. We report here the distinct roles of mycobacterial P1B4-ATP
Publikováno v:
Molecular Microbiology. 100:1066-1079
Listeria monocytogenes FrvA (Lmo0641) is critical for virulence in the mouse model and is an ortholog of the Bacillus subtilis Fur- and PerR-regulated Fe(II) efflux P1B4 -type ATPase PfeT. Previously, FrvA was suggested to protect against heme toxici
Publikováno v:
Metallomics. 8:906-914
The early discovery of the human Cu(+)-ATPases and their link to Menkes and Wilson's diseases brought attention to the unique role of these transporters in copper homeostasis. The characterization of bacterial Cu(+)-ATPases has significantly furthere
Autor:
Sarju J. Patel, John D. Helmann, Ahmed Gaballa, Guohua Guan, Azul Pinochet-Barros, José M. Argüello
Publikováno v:
Molecular Microbiology. 98:787-803
Iron is an essential element for nearly all cells and limited iron availability often restricts growth. However, excess iron can also be deleterious, particularly when cells expressing high affinity iron uptake systems transition to iron rich environ
Publikováno v:
Microbiology. 160:1237-1251
Copper is an important element in host–microbe interactions, acting both as a catalyst in enzymes and as a potential toxin. Cu+-ATPases drive cytoplasmic Cu+ efflux and protect bacteria against metal overload. Many pathogenic and symbiotic bacteria