Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Saritha Kusam"'
Autor:
Archana Vijayakumar, Ayse Okesli‐Armlovich, Ting Wang, Isabel Olson, Minji Seung, Saritha Kusam, David Hollenback, Sangeetha Mahadevan, Bruno Marchand, Maria Toteva, David G. Breckenridge, James L. Trevaskis, Jamie Bates
Publikováno v:
Hepatology Communications, Vol 6, Iss 9, Pp 2298-2309 (2022)
Abstract Dysregulated hepatocyte lipid metabolism is a hallmark of hepatic lipotoxicity and contributes to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl CoA carboxylase (ACC) inhibitors decrease hepatocyte lipotoxicity by inhibiting
Externí odkaz:
https://doaj.org/article/fcccdbbbcc8c483fa465bc4bd08eb25c
Autor:
Swetha Pendem, Igor Mikaelian, Sarani Ghoshal, Anna Zagorska, Archana Vijayakumar, Katie Walker, Bryan C. Fuchs, Robert Brockett, K. Liu, Bruno Marchand, David Lopez, David G. Breckenridge, Li Li, Ricardo Ramirez, Jamie Bates, Saritha Kusam, Dmytro Kornyeyev, Saili Yi, David Newstrom, David Hollenback
Publikováno v:
Journal of Hepatology. 73:896-905
Background & Aims Non-alcoholic steatohepatitis (NASH) is a chronic liver disease characterized by hepatic lipid accumulation, inflammation, and progressive fibrosis. Acetyl-CoA carboxylase (ACC) catalyzes the rate-limiting step of de novo lipogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26e3434ea9bae5e5487db79bd3c5389
https://doi.org/10.1016/j.jhep.2020.04.037
https://doi.org/10.1016/j.jhep.2020.04.037
Autor:
Wanchi Fung, Kobayashi Tetsuya, Anita Niedziela-Majka, Bob Jiang, Kim Jordan, Saritha Kusam, David G. Breckenridge, Hai Yang, Britton Kenneth Corkey, Kristyna Elbel, Chin Tay, Elaine Kan, Sammy Metobo, David Sperandio, Du Jinfa, Richard M. Neve, Sophia L. Shevick, Eric B. Lansdon, Kerim Babaoglu, Gregory Chin, Heather Webb, Debi Jin, Annapurna Sapre, Vangelis Aktoudianakis, Latesh Lad, Jamie Bates, Xiaowu Chen, Jeff Zablocki, Gene Eisenberg, Nate Larson, Richard L. Mackman, Martinez Ruben, Magdeleine Hung, Zachary Newby, Mish Michael R
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:457-469
The bromodomain and extra-terminal (BET) family of proteins, consisting of the bromodomains containing protein 2 (BRD2), BRD3, BRD4, and the testis-specific BRDT, are key epigenetic regulators of gene transcription and has emerged as an attractive ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32393d33e86182931fa91168f5389d3c
https://doi.org/10.1016/j.bmc.2018.11.020
https://doi.org/10.1016/j.bmc.2018.11.020
Autor:
Dwayne Carter, Grasiella Andriani, Sushma Jadalannagari, Sauveur Jeanty, John Sauld, Sannidhi Joshipura, Jamie Bates, Saritha Kusam, Diego Miranda, Ayse Okesli Armlovich, Archana Vijayakumar, Kyung-Jin Jang, Geraldine Hamilton, Katia Karalis, James Trevaskis
Publikováno v:
Journal of Hepatology. 73:S660
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f5da764306ad3cf268ee7b93a407847
https://doi.org/10.1016/s0168-8278(20)31782-7
https://doi.org/10.1016/s0168-8278(20)31782-7
Autor:
David G. Breckenridge, Harini Burri, Saritha Kusam, Archana Vijayakumar, Jamie Bates, David Hollenback
Publikováno v:
Journal of Hepatology. 70:e520-e521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f08910071a8fd39e0e59f81d832073e8
https://doi.org/10.1016/s0618-8278(19)31029-1
https://doi.org/10.1016/s0618-8278(19)31029-1
Autor:
Anna Zagorska, Ting Wang, Robert Brockett, Jamie Bates, K. Liu, Igor Mikaelian, David Hollenback, H. Liu, Adrian S. Ray, Grant R. Budas, David G. Breckenridge, John T. Liles, David Newstrom, Saritha Kusam
Publikováno v:
Journal of Hepatology. 68:S395-S396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27317af625d84b004f6d186e7e681987
https://doi.org/10.1016/s0168-8278(18)31026-2
https://doi.org/10.1016/s0168-8278(18)31026-2
Autor:
David G. Breckenridge, William F. Westlin, Saritha Kusam, K. Liu, Bryan C. Fuchs, Geraldine Harriman, David Hollenback, Ting Wang, Rosana Kapeller, H.J. Harwood, Lan Wei, David Newstrom, Jennifer Rocnik, Jamie Bates, H. Liu, Igor Mikaelian, M. Sulfab, Sarani Ghoshal, R. Brockett, Adrian S. Ray
Publikováno v:
Journal of Hepatology. 68:S399-S400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fc7b66861e0593179d3dcbe8d8c1721
https://doi.org/10.1016/s0168-8278(18)31036-5
https://doi.org/10.1016/s0168-8278(18)31036-5
Autor:
Wayne J. Fairbrother, Pawan Bir Kohli, Adam R. Johnson, Lisa D. Belmont, Ingrid E. Wertz, Mike Eby, Toru Okamoto, Mark L. Chiu, Cynthia Lam, Somasekar Seshagiri, Jinfeng Liu, Elizabeth Helgason, Jennie R. Lill, Kanan Pujara, Saritha Kusam, Heather Maecker, Vishva M. Dixit, Karen O'Rourke, Mary J. C. Ludlam, Peter K. Jackson, Wendy Sandoval, Erin C. Dueber, Daniel Anderson, Kevin G. Leong, James A. Ernst, David C.S. Huang, Joshua S. Kaminker
Publikováno v:
Nature. 471:110-114
Microtubules have pivotal roles in fundamental cellular processes and are targets of antitubulin chemotherapeutics. Microtubule-targeted agents such as Taxol and vincristine are prescribed widely for various malignancies, including ovarian and breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65722c051c97fcde2008a4449844f5bb
https://doi.org/10.1038/nature09779
https://doi.org/10.1038/nature09779
Autor:
Sarah G. Hymowitz, Qui Phung, Vishva M. Dixit, Ivan Bosanac, Saritha Kusam, Donald S. Kirkpatrick, Cynthia Lam, Borlan Pan, Lilian Phu, David Arnott, Ingrid E. Wertz, Brigitte Maurer, Christine Yu
Publikováno v:
Molecular Cell. 40:548-557
Inactivating mutations in the ubiquitin (Ub) editing protein A20 promote persistent nuclear factor (NF)-κB signaling and are genetically linked to inflammatory diseases and hematologic cancers. A20 tightly regulates NF-κB signaling by acting as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e101d29088e7f2ae908ea1a004b136d5
https://doi.org/10.1016/j.molcel.2010.10.009
https://doi.org/10.1016/j.molcel.2010.10.009
Autor:
Robert J. Newman, Mercedesz Balazs, Kebing Yu, Jinfeng Liu, Keisuke Horikawa, Wendy Sandoval, Wyne P. Lee, Kim Newton, Flavius Martin, Michael J. Townsend, Nandhini Ramamoorthi, Lorna Kategaya, Jeffrey Tom, Erin C. Dueber, Wayne J. Fairbrother, Christopher C. Goodnow, Allyn J. Schoeffler, Saritha Kusam, Anuradha Zindal, Vishva M. Dixit, Clifford Quan, Ganesh Kolumam, Elizabeth Helgason, Juan Zhang, Debra L. Dugger, Jason DeVoss, Cynthia Lam, Surinder Jeet, Søren Warming, Patrick Caplazi, Dhaya Seshasayee, Susmith Mukund, Ingrid E. Wertz, Nataliya Popovych
Publikováno v:
Nature. 528(7582)
Inactivation of the TNFAIP3 gene, encoding the A20 protein, is associated with critical inflammatory diseases including multiple sclerosis, rheumatoid arthritis and Crohn's disease. However, the role of A20 in attenuating inflammatory signalling is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06cb1b428a81f2eeee8a97177d2ad31
https://pubmed.ncbi.nlm.nih.gov/26760210
https://pubmed.ncbi.nlm.nih.gov/26760210