Výsledky vyhledávání - "Sarita R, Shah"

Novel polymer-based system for intrauterine delivery of everolimus for anti-cancer applications

Autor: Bryan Fellman, Qian Zhang, Rosemarie Schmandt, Joseph A. Dottino, Kayleah Cumpian, Antonios G. Mikos, Yunyun Jiang, Karen H. Lu, Mikayla S. Borthwick, Hannah A. Pearce, Brenda Melendez, Emma Watson, Joseph Celestino, Ying Yuan, Melinda S. Yates, Sarita R. Shah

Publikováno v: J Control Release

Non-surgical treatment options for low-grade endometrial cancer and precancerous lesions are a critical unmet need for women who wish to preserve fertility or are unable to undergo hysterectomy. The PI3K/AKT/mTOR pathway is frequently activated in en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0b5204f7830171ebefaacb23cb072c
https://pubmed.ncbi.nlm.nih.gov/34648891

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Polymer-Based Local Antibiotic Delivery for Prevention of Polymicrobial Infection in Contaminated Mandibular Implants

Autor: John A. Jansen, Alexander M. Tatara, Antonios G. Mikos, Jeroen J.J.P. van den Beucken, David Scott, George N. Bennett, Steven Lu, Sarita R. Shah, Johnny Lam, Mark E. Wong

Publikováno v: ACS biomaterials scienceengineering. 2(4)

Antibiotic-releasing porous poly(methyl methacrylate) (PMMA) space maintainers, comprising PMMA with an aqueous porogen and a poly(DL-lactic-co-glycolic acid) (PLGA) antibiotic carrier, have been developed to facilitate local delivery of antibiotics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4241ac42c794e2285a9e4967a80efe2
https://pubmed.ncbi.nlm.nih.gov/33465859

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Effects of Local Antibiotic Delivery from Porous Space Maintainers on Infection Clearance and Induction of an Osteogenic Membrane in an Infected Bone Defect

Autor: Eric R. Molina, Brandon T. Smith, Alexander M. Tatara, George N. Bennett, Antonios G. Mikos, Joseph C. Wenke, Trenton C. Piepergerdes, Esther J. Lee, Robert E. Guldberg, Brent A. Uhrig, Sarita R. Shah

Publikováno v: Tissue Engineering Part A. 23:91-100

Reconstruction of large bone defects can be complicated by the presence of both infection and local antibiotic administration. This can be addressed through a two-stage reconstructive approach, called the Masquelet technique, that involves the genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8faddbaa3db93a6d81ef8e99959aa377
https://doi.org/10.1089/ten.tea.2016.0389

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Biomaterials-aided mandibular reconstruction using in vivo bioreactors

Autor: James C. Melville, Anthony Ratcliffe, Tang Ho, John A. Jansen, Jonathan W. Shum, Emma Watson, Mark E. Wong, Brandon T. Smith, Issa A. Hanna, Alexander M. Tatara, Nagi Demian, Antonios G. Mikos, Sarita R. Shah, Gerry L. Koons, Jeroen J.J.P. van den Beucken, Trenton C. Piepergerdes

Publikováno v: Proceedings of the National Academy of Sciences USA, 116, 14, pp. 6954-6963
Proceedings of the National Academy of Sciences USA, 116, 6954-6963

Large mandibular defects are clinically challenging to reconstruct due to the complex anatomy of the jaw and the limited availability of appropriate tissue for repair. We envision leveraging current advances in fabrication and biomaterials to create

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fcb3ea200f84a6cb3780dc52e9960b1
https://hdl.handle.net/2066/202772

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Biodegradable, phosphate-containing, dual-gelling macromers for cellular delivery in bone tissue engineering

Autor: Paul S. Engel, Brendan M. Watson, Antonios G. Mikos, David Scott, Sarita R. Shah, Alexander M. Tatara, Tiffany N. Vo

Publikováno v: Biomaterials. 67:286-296

Injectable, biodegradable, dual-gelling macromer solutions were used to encapsulate mesenchymal stem cells (MSCs) within stable hydrogels when elevated to physiologic temperature. Pendant phosphate groups were incorporated in the N-isopropyl acrylami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d722565d0f0a25a085750668b2f94246
https://doi.org/10.1016/j.biomaterials.2015.07.016

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Infected animal models for tissue engineering

Autor: Antonios G. Mikos, Sarita R. Shah, Alexander M. Tatara, Carissa E. Livingston

Publikováno v: Methods. 84:17-24

Infection is one of the most common complications associated with medical interventions and implants. As tissue engineering strategies to replace missing or damaged tissue advance, the focus on prevention and treatment of concomitant infection has al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da3d1397e6a14a2c15eba91f0953b49
https://doi.org/10.1016/j.ymeth.2015.03.025

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Cutaneous metastasis to the scalp as the primary presentation of colorectal adenocarcinoma

Autor: Sarita R, Shah, Danielle S, Applebaum, Silvia, Potenziani, Yve T, Huttenbach, John, Wolf, Ida F, Orengo

Publikováno v: Dermatology online journal. 23(11)

Eruptaneous metastasis is an uncommon presentation of colorectal adenocarcinoma that can occur years after diagnosis of the primary cancer or manifest as the first sign of malignancy. It is essential to diagnose these metastases immediately, as this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88f6f157a05f826c91bdc113b4877c59
https://pubmed.ncbi.nlm.nih.gov/29447644

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Degradable, antibiotic releasing poly(propylene fumarate)-based constructs for craniofacial space maintenance applications

Autor: F. Kurtis Kasper, Sarita R. Shah, Mark E. Wong, Allan M. Henslee, Antonios G. Mikos

Publikováno v: Journal of Biomedical Materials Research Part A. 103:1485-1497

Space maintainers (SMs) used for craniofacial reconstruction function to preserve the void space created upon bone loss and promote soft tissue healing over the defect. Polymethylmethacrylate-based SMs present several drawbacks including implant expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c32f7897a1b77f3840dee70bf8a26f6
https://doi.org/10.1002/jbm.a.35288

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Use of Porous Space Maintainers in Staged Mandibular Reconstruction

Autor: Alexander M. Tatara, Antonios G. Mikos, Mark E. Wong, F. Kurtis Kasper, Sarita R. Shah, Patrick P. Spicer, Allan M. Henslee

Publikováno v: Oral and Maxillofacial Surgery Clinics of North America. 26:143-149

The success of mandibular reconstructions depends not only on restoring the form and function of lost bone but also on the preservation of the overlying soft tissue layer. In this case study, 5 porous polymethylmethacrylate space maintainers fabricat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3e2076418bd5a17cb05ce78a434bf0
https://doi.org/10.1016/j.coms.2014.01.002

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