Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sarita Maman"'
Autor:
Ian M. Hardern, Jarrod Walsh, Ed Wheatley, Jon Winter-Holt, Sarita Maman, Judit E. Debreczeni, Graeme Walker, Susan E. Critchlow, Gareth M. Davies, Nicola J. Evans, Richard A. Ward, Neil P. Jones, Sheila B. McLoughlin, Andrew Peter Thomas, Neil Bennett, Geoff Holdgate, Nicola Curtis, Stephen A. St-Gallay, Lindsey Leach, Laurent Rigoreau, Andrew P. Turnbull, Marian Preston
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(1)
A high-throughput screen (HTS) of human 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) resulted in several series of compounds with the potential for further optimization. Informatics was used to identify active chemotypes with lead-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb293272e1c04a39e000a87f72a6166
https://pubmed.ncbi.nlm.nih.gov/28945981
https://pubmed.ncbi.nlm.nih.gov/28945981
Autor:
Vikki Flemington, Jon Winter, Sarita Maman, Marian Preston, Martin E. Swarbrick, Piotr Raubo, Iris Treinies, Graeme R. Robb, Karen Roberts, Rachel Rowlinson, James M. Smith, David M. Andrews, Robert J.K. Wood, Paul Faulder, Michael J. Waring, Jennifer C. McKelvie
Publikováno v:
Chem. Commun.. 50:5388-5390
Two series of inhibitors of type III phosphatidylinositol-4-kinase were identified by high throughput screening and optimised to derive probe compounds that independently and selectively inhibit the α- and the β-isoforms with no significant activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ddece18a99e90543a3614dbe27894a
https://doi.org/10.1039/c3cc48391f
https://doi.org/10.1039/c3cc48391f
Autor:
David M. Cross, Glyn Williams, Steven Howard, Julia E. Matthews, Marc O'Reilly, Mladen Vinkovic, Paul Graham Wyatt, Adrian Liam Gill, Lindsay A. Devine, John A. Boulstridge, Jayne Curry, Lynsey Fazal, Michelle Heathcote, Rachel McMenamin, Eva Figueroa Navarro, Valerio Berdini, Michael Alistair O'brien, Sarita Maman, Maria Grazia Carr, Theresa Rachel Early, Dominic Tisi, Matthias Reule, David C. Rees
Publikováno v:
Journal of Medicinal Chemistry. 52:379-388
Here, we describe the identification of a clinical candidate via structure-based optimization of a ligand efficient pyrazole-benzimidazole fragment. Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da04922729ad83e0f7fa4188e4f45b3
https://doi.org/10.1021/jm800984v
https://doi.org/10.1021/jm800984v
Autor:
David R. Jones, O. Kern, Jennifer C. McKelvie, D. Fitzgerald, Sarita Maman, Michael J. Waring, C.D. Jones, E. MacDonald, M. Riddick, N. Divecha, Vikki Flemington, Graeme R. Robb, Kurt Gordon Pike, Robert J.K. Wood, I. Treinies, Martin E. Swarbrick, S. Cosulich, James M. Smith, Karen Roberts, David M. Andrews
Publikováno v:
European Journal of Cancer. 50:91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a5173e364e1b2b70b9485c1fb3eb354
https://doi.org/10.1016/s0959-8049(14)70401-0
https://doi.org/10.1016/s0959-8049(14)70401-0
Autor:
Graeme R. Robb, James W. Smith, Piotr Raubo, Martin E. Swarbrick, Darren Cross, David M. Andrews, Jennifer C. McKelvie, Carol Lenaghan, Sarita Maman, Michael J. Waring, Vikki Flemington
Publikováno v:
Cancer Research. 73:2228-2228
Phosphatidylinositol (PI) is a phospholipid that resides primarily on the cytosolic surface of cell membranes. PI can be phosphorylated to generate seven different phosphatidylinositol phosphates (PIPs), all of which have distinct biological activiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddd9cb914d82ca98f0f378b2e22e49e2
https://doi.org/10.1158/1538-7445.am2013-2228
https://doi.org/10.1158/1538-7445.am2013-2228