Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sarita Lagalwar"'
Autor:
Sarita Lagalwar
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Tunneling nanotubes (TNTs), intercellular connections enriched with F-actin, were first identified as a viable means of cellular communication and organelle transport in animal cells at the early part of this century. Within the last 10 years, these
Externí odkaz:
https://doaj.org/article/9cf056a3c7e34e8faaae417007ae10fc
Robust light–dark patterns and reduced amyloid load in an Alzheimer’s disease transgenic mouse model
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Circadian disruption resulting from exposure to irregular light–dark patterns and sleep deprivation has been associated with beta amyloid peptide (Aβ) aggregation, which is a major event in Alzheimer’s disease (AD) pathology. We exposed
Externí odkaz:
https://doaj.org/article/cc14f28708994586990708e7d9e1fb40
Autor:
Stephen J. Ives, Kendall S. Zaleski, Cheyanne Slocum, Daniela Escudero, Caty Sheridan, Saada Legesse, Kavey Vidal, Sarita Lagalwar, Thomas H. Reynolds
Publikováno v:
Physiological Reports, Vol 8, Iss 21, Pp n/a-n/a (2020)
Abstract Obesity, insulin resistance, and poor metabolic profile are hallmarks of a high‐fat diet (HFD), highlighting the need to understand underlying mechanisms. Therefore, we sought to determine the effect of succinic acid (SA) on metabolism in
Externí odkaz:
https://doaj.org/article/e4c691e191164d6984c747dd38193fe9
Autor:
Judit M. Pérez Ortiz, Nissa Mollema, Nicholas Toker, Carolyn J. Adamski, Brennon O'Callaghan, Lisa Duvick, Jillian Friedrich, Michael A. Walters, Jessica Strasser, Jon E. Hawkinson, Huda Y. Zoghbi, Christine Henzler, Harry T. Orr, Sarita Lagalwar
Publikováno v:
Neurobiology of Disease, Vol 116, Iss , Pp 93-105 (2018)
Spinocerebellar ataxia type 1 (SCA1) is a polyglutamine (polyQ) repeat neurodegenerative disease in which a primary site of pathogenesis are cerebellar Purkinje cells. In addition to polyQ expansion of ataxin-1 protein (ATXN1), phosphorylation of ATX
Externí odkaz:
https://doaj.org/article/b9f62c15636b4d38bc9157a6c5c1ed0f
Autor:
Lindsey J. Shinn, Sarita Lagalwar
Publikováno v:
Antioxidants, Vol 10, Iss 4, p 573 (2021)
Growing evidence from neurodegenerative disease research supports an early pathogenic role for mitochondrial dysfunction in affected neurons that precedes morphological and functional deficits. The resulting oxidative stress and respiratory malfuncti
Externí odkaz:
https://doaj.org/article/34b8bba4736c4922836406ff7ca3611d
Autor:
Mayumi F. Kohiyama, Sarita Lagalwar
Publikováno v:
Journal of Experimental Neuroscience, Vol 2015, Iss Suppl. 2, Pp 123-129 (2016)
Externí odkaz:
https://doaj.org/article/1c1d3bf5e7e8430eac0bfc627c125e7d
Autor:
Austin Ferro, Emily Carbone, Jenny Zhang, Evan Marzouk, Monica Villegas, Asher Siegel, Donna Nguyen, Thomas Possidente, Jessilyn Hartman, Kailen Polley, Melissa A Ingram, Georgia Berry, Thomas H Reynolds, Bernard Possidente, Kimberley Frederick, Stephen Ives, Sarita Lagalwar
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188425 (2017)
Mitochondrial dysfunction plays a significant role in neurodegenerative disease including ataxias and other movement disorders, particularly those marked by progressive degeneration in the cerebellum. In this study, we investigate the role of mitocho
Externí odkaz:
https://doaj.org/article/ea6b5d244b594a9a89697348781e7a12
Autor:
Mayumi F. Kohiyama, Sarita Lagalwar
Publikováno v:
Journal of Experimental Neuroscience, Vol 9s2 (2015)
Aggregation-prone proteins in neurodegenerative disease disrupt cellular protein stabilization and degradation pathways. The neurodegenerative disease spinocerebellar ataxia type 1 (SCA1) is caused by a coding polyglutamine expansion in the Ataxin-1
Externí odkaz:
https://doaj.org/article/4c569852535d486ebd11b7cf50678809
Autor:
Kwang-Jin Oh, Sylvia E. Perez, Sarita Lagalwar, Laurel Vana, Lester Binder, Elliott J. Mufson
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2010 (2010)
The age-related pathological cascade underlying intraneuronal tau formation in 3xTg-AD mice, which harbor the human APPSwe, PS1M126V , and TauP301L gene mutations, remains unclear. At 3 weeks of age, AT180, Alz50, MC1, AT8, and PHF-1 intraneuronal im
Externí odkaz:
https://doaj.org/article/19ce712aa5424c0b8c98c9f32376c200
Autor:
Joan E LLabre, Cristianel Gil, Neha Amatya, Sarita Lagalwar, Bernard Possidente, Deepak Vashishth
Publikováno v:
Journal of Bone and Mineral Research. 37:2548-2565
Alzheimer's disease (AD) patients present with symptoms such as impairment of insulin signaling, chronic inflammation, and oxidative stress. Furthermore, there are comorbidities associated with AD progression. For example, osteoporosis is common with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa75467e466f0cf3659e8e3e92985af
https://doi.org/10.1002/jbmr.4723
https://doi.org/10.1002/jbmr.4723