Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sarita Hebbar"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010644 (2023)
Tissue health is regulated by a myriad of exogenous or endogenous factors. Here we investigated the role of the conserved Kynurenine pathway (KP) in maintaining retinal homeostasis in the context of light stress in Drosophila melanogaster. cinnabar,
Externí odkaz:
https://doaj.org/article/8779d396c6f64584b00e97d432ec342f
Autor:
Sarita Hebbar, Malte Lehmann, Sarah Behrens, Catrin Hälsig, Weihua Leng, Michaela Yuan, Sylke Winkler, Elisabeth Knust
Publikováno v:
Biology Open, Vol 10, Iss 1 (2021)
Retinitis pigmentosa (RP) is a clinically heterogeneous disease affecting 1.6 million people worldwide. The second-largest group of genes causing autosomal dominant RP in human encodes regulators of the splicing machinery. Yet, how defects in splicin
Externí odkaz:
https://doaj.org/article/6d6ef59b3e864ad98c68efb472a629af
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Externí odkaz:
https://doaj.org/article/2c1f71320edf4bd5b7f3a7586d242969
Autor:
Samantha J. Hindle, Sarita Hebbar, Dominik Schwudke, Christopher J.H. Elliott, Sean T. Sweeney
Publikováno v:
Neurobiology of Disease, Vol 98, Iss , Pp 77-87 (2017)
Saposin deficiency is a childhood neurodegenerative lysosomal storage disorder (LSD) that can cause premature death within three months of life. Saposins are activator proteins that promote the function of lysosomal hydrolases that mediate the degrad
Externí odkaz:
https://doaj.org/article/07e2643c00114f30b27667dc7e19b429
Autor:
Stephanie Spannl, Alexandra Kumichel, Sarita Hebbar, Katja Kapp, Marcos Gonzalez-Gaitan, Sylke Winkler, Rosana Blawid, Gregor Jessberger, Elisabeth Knust
Publikováno v:
Biology Open, Vol 6, Iss 2, Pp 165-175 (2017)
Drosophila Crumbs (Crb) is a key regulator of epithelial polarity and fulfils a plethora of other functions, such as growth regulation, morphogenesis of photoreceptor cells and prevention of retinal degeneration. This raises the question how a single
Externí odkaz:
https://doaj.org/article/411f0cec515447479f5f1b6315e2807d
Autor:
Sarita Hebbar, Esther Lee, Manoj Manna, Steffen Steinert, Goparaju Sravan Kumar, Markus Wenk, Thorsten Wohland, Rachel Kraut
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 5, Pp 1077-1089 (2008)
We have designed a tagged probe [sphingolipid binding domain (SBD)] to facilitate the tracking of intracellular movements of sphingolipids in living neuronal cells. SBD is a small peptide consisting of the SBD of the amyloid precursor protein. It can
Externí odkaz:
https://doaj.org/article/c33a6833ba8b4837b8cde107b58dad54
Autor:
Steffen Steinert, Esther Lee, Guillaume Tresset, Dawei Zhang, Ralf Hortsch, Richard Wetzel, Sarita Hebbar, Jeyapriya Raja Sundram, Sashi Kesavapany, Elke Boschke, Rachel Kraut
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2933 (2008)
BACKGROUND: The uptake and intracellular trafficking of sphingolipids, which self-associate into plasma membrane microdomains, is associated with many pathological conditions, including viral and toxin infection, lipid storage disease, and neurodegen
Externí odkaz:
https://doaj.org/article/165af528bfaf4e0f88a4833a9eca74c7
Tissue health is regulated by a myriad of exogenous or endogenous factors. Here we investigated the role of the conserved Kynurenine pathway (KP) in maintaining retinal homeostasis in the context of light stress in Drosophila melanogaster. cinnabar,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa90880b627acb80787114f8ede2cf05
https://doi.org/10.1101/2022.09.10.507411
https://doi.org/10.1101/2022.09.10.507411
Autor:
Elisabeth Knust, Sarita Hebbar
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biologyREFERENCES. 43(8)
Reactive oxygen species (ROS) are highly reactive molecules produced in cells. So far, they have mostly been connected to diseases and pathological conditions. More recent results revealed a somewhat unexpected role of ROS in control of developmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7738bfde8155f06fdbb6ab696a7e0adc
https://pubmed.ncbi.nlm.nih.gov/34260754
https://pubmed.ncbi.nlm.nih.gov/34260754
Autor:
Sylke Winkler, Sarah Behrens, Weihua Leng, Catrin Hälsig, Elisabeth Knust, Michaela Yuan, Sarita Hebbar, Malte Lehmann
Publikováno v:
Biology Open, Vol 10, Iss 1 (2021)
Retinitis pigmentosa (RP) is a clinically heterogeneous disease affecting 1.6 million people worldwide. The second-largest group of genes causing autosomal dominant RP in human encodes regulators of the splicing machinery. Yet, how defects in splicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf4672a7358267a36f4338715f55943
https://doi.org/10.1242/bio.052332
https://doi.org/10.1242/bio.052332