To Be or Not to Be Eisenmenger

Autor: Raghav Murthy, Sarit S. Cohen, Sathiji Nageshwaran, Jennifer L. Cohen, Barry Love, Ali N. Zaidi, Simone Jhaveri, Alice Chan

Publikováno v: JACC Case Reports
JACC: Case Reports, Vol 3, Iss 2, Pp 230-235 (2021)

Eisenmenger syndrome refers to any untreated congenital cardiac defect with an intracardiac communication that leads to pulmonary arterial hypertension, reversal of intracardiac shunting, and cyanosis. We describe a 40-year-old cyanotic patient with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8cdbc2bdfe89d10c76ebd7e353969c
http://europepmc.org/articles/PMC8310966

Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants.

Autor: Capener JL; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Katis VL; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK., Michaud A; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Beck MT; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Daglish SCD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cohen-Kedar S; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Barda ES; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Howell S; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dotan I; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Robers MB; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Axtman AD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Bashore FM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 13. Date of Electronic Publication: 2024 Jun 13.

Loss of function of ENT3 drives histiocytosis and inflammation through TLR-MAPK signaling.

Autor: Shiloh R; The Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petach Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel., Lubin R; The Institute of Biomedical and Oral Research, Hebrew University, Jerusalem, Israel., David O; Pediatric Endocrinology Unit, Soroka University Medical Center, Beer Sheva, Israel.; Pediatric Ambulatory Center, Soroka University Medical Center, Beer Sheva, Israel.; Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel., Geron I; The Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petach Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel., Okon E; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Hazan I; The Institute of Biomedical and Oral Research, Hebrew University, Jerusalem, Israel., Zaliova M; Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine of Charles University Prague and University Hospital Motol, Prague, Czech Republic., Amarilyo G; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Rheumatology Unit, Schneider Children's Medical Center, Petach Tikva, Israel., Birger Y; The Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petach Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel., Borovitz Y; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Institute of Nephrology, Schneider Children's Medical Center, Petach Tikva, Israel., Brik D; The Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petach Tikva, Israel., Broides A; Pediatric Ambulatory Center, Soroka University Medical Center, Beer Sheva, Israel.; Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.; Pediatric Immunology Clinic, Soroka University Medical Center, Beer Sheva, Israel., Cohen-Kedar S; Felsenstein Medical Research Center, Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.; Division of Gastroenterology, Rabin Medical Center, Petach Tikva, Israel., Harel L; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Rheumatology Unit, Schneider Children's Medical Center, Petach Tikva, Israel., Kristal E; Pediatric Ambulatory Center, Soroka University Medical Center, Beer Sheva, Israel.; Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.; Pediatric Immunology Clinic, Soroka University Medical Center, Beer Sheva, Israel., Kozlova D; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Pathology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel., Ling G; Pediatric Ambulatory Center, Soroka University Medical Center, Beer Sheva, Israel.; Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel., Shapira Rootman M; Department of Radiology, Rambam Health Care Campus, Haifa, Israel., Shefer Averbuch N; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Genetics Clinic, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.; The Jesse and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petach Tikva, Israel., Spielman S; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Pediatrics A, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel., Trka J; Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine of Charles University Prague and University Hospital Motol, Prague, Czech Republic., Izraeli S; The Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petach Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Beckman Research Institute, City of Hope, Duarte, CA., Yona S; The Institute of Biomedical and Oral Research, Hebrew University, Jerusalem, Israel., Elitzur S; The Rina Zaizov Division of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petach Tikva, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Publikováno v: Blood [Blood] 2023 Nov 16; Vol. 142 (20), pp. 1740-1751.

A Phase I, Open-label, Randomized, Crossover Study of the Relative Bioavailability of Capsule and Granule Formulations of Selumetinib.

Autor: Cohen-Rabbie S; Clinical Pharmacology and Safety Science Biopharmaceutics Research and Development, AstraZeneca, Cambridge, United Kingdom. Electronic address: sarit.rabbie@astrazeneca.com., Mattinson A; Oral Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, United Kingdom., So K; Oncology Research and Development, AstraZeneca, Cambridge, United Kingdom., Wang N; Late Oncology Statistics, Research and Development, AstraZeneca, Cambridge, United Kingdom., Goldwater R; Parexel International, Baltimore, Maryland.

Publikováno v: Clinical therapeutics [Clin Ther] 2022 Apr; Vol. 44 (4), pp. 565-576. Date of Electronic Publication: 2022 Apr 09.

Concentration-QT modelling in early clinical oncology settings: Simulation evaluation of performance.

Autor: Cantet G; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Berges A; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.; Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, UK., O'Sullivan R; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Cohen-Rabbie S; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Dota C; Cardiovascular Safety Centre of Excellence, CMO, Oncology R&D, Gothenburg, Sweden., Dubois V; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Benoist GE; Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands., Tomkinson H; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Rekić D; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Parkinson J; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Schalkwijk S; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK.; Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, UK.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2022 Mar; Vol. 88 (3), pp. 1010-1019. Date of Electronic Publication: 2021 Sep 09.