Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Sarina, Ravens"'
Autor:
Alexa Cramer, Tao Yang, Lennart Riemann, Vicente Almeida, Christoph Kammeyer, Yusuf E. Abu, Elisa Gluschke, Svea Kleiner, Ximena León-Lara, Anika Janssen, Alejandro Hofmann, Alexander Horke, Constantin von Kaisenberg, Reinhold Förster, Philipp Beerbaum, Martin Boehne, Sarina Ravens
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Congenital heart disease (CHD) is the most common birth defect in newborns, often requiring cardiac surgery with concomitant thymectomy that is known to increase disease susceptibility later in life. Studies of γδ T cells, which are one of
Externí odkaz:
https://doaj.org/article/c93e78fb0c144e54ac248de9a9bf1f5f
Autor:
Sara Terzoli, Paolo Marzano, Valentina Cazzetta, Rocco Piazza, Inga Sandrock, Sarina Ravens, Likai Tan, Immo Prinz, Simone Balin, Michela Calvi, Anna Carletti, Assunta Cancellara, Nicolò Coianiz, Sara Franzese, Alessandro Frigo, Antonio Voza, Francesca Calcaterra, Clara Di Vito, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-16 (2024)
Abstract γδ T cells provide rapid cellular immunity against pathogens. Here, we conducted matched single-cell RNA-sequencing and γδ-TCR-sequencing to delineate the molecular changes in γδ T cells during a longitudinal study following mRNA SARS-
Externí odkaz:
https://doaj.org/article/ed82b5055e4e4c92886da6d4f57cfc8d
Autor:
Tao Yang, Joana Barros-Martins, Ziqing Wang, Melanie Wencker, Jiang Zhang, Justine Smout, Prerna Gambhir, Anika Janssen, Anja Schimrock, Hristo Georgiev, Ximena León-Lara, Siegfried Weiss, Jochen Huehn, Immo Prinz, Andreas Krueger, Reinhold Foerster, Thierry Walzer, Sarina Ravens
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113230- (2023)
Summary: T cell receptor (TCR) Vγ4-expressing γδ T cells comprise interferon γ (IFNγ)- and interleukin-17 (IL-17)-producing effector subsets, with a preference for IL-17 effector fate decisions during early ontogeny. The existence of adult-thymu
Externí odkaz:
https://doaj.org/article/883e2cd2888841afb860c5952de372a1
Autor:
Paolo Marzano, Simone Balin, Sara Terzoli, Silvia Della Bella, Valentina Cazzetta, Rocco Piazza, Inga Sandrock, Sarina Ravens, Likai Tan, Immo Prinz, Francesca Calcaterra, Clara Di Vito, Assunta Cancellara, Michela Calvi, Anna Carletti, Sara Franzese, Alessandro Frigo, Ahmed Darwish, Antonio Voza, Joanna Mikulak, Domenico Mavilio
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHigher frequencies of mucosal-associated invariant T (MAIT) cells were associated with an increased adaptive response to mRNA BNT162b2 SARS-CoV-2 vaccine, however, the mechanistic insights into this relationship are unknown. In the presen
Externí odkaz:
https://doaj.org/article/df9be936320446999214947427c0b25e
Autor:
Agnes Bonifacius, Britta Lamottke, Sabine Tischer-Zimmermann, Rebecca Schultze-Florey, Lilia Goudeva, Hans-Gert Heuft, Lubomir Arseniev, Rita Beier, Gernot Beutel, Gunnar Cario, Birgit Fröhlich, Johann Greil, Leo Hansmann, Justin Hasenkamp, Michaela Höfs, Patrick Hundsdoerfer, Edgar Jost, Kinan Kafa, Oliver Kriege, Nicolaus Kröger, Stephan Mathas, Roland Meisel, Michaela Nathrath, Mervi Putkonen, Sarina Ravens, Hans Christian Reinhardt, Elisa Sala, Martin G. Sauer, Clemens Schmitt, Roland Schroers, Nina Kristin Steckel, Ralf Ulrich Trappe, Mareike Verbeek, Daniel Wolff, Rainer Blasczyk, Britta Eiz-Vesper, Britta Maecker-Kolhoff
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
BACKGROUND Adoptive transfer of EBV-specific T cells can restore specific immunity in immunocompromised patients with EBV-associated complications.METHODS We provide results of a personalized T cell manufacturing program evaluating donor, patient, T
Externí odkaz:
https://doaj.org/article/90b7781e7f1547e9ab2df6d697ea2d7d
A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages
Autor:
Anne M. Hahn, Lisa Vogg, Stefanie Brey, Andrea Schneider, Simon Schäfer, Ralph Palmisano, Anna Pavlova, Inga Sandrock, Likai Tan, Alina S. Fichtner, Immo Prinz, Sarina Ravens, Thomas H. Winkler
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112558- (2023)
Externí odkaz:
https://doaj.org/article/fa58b1206f1f464ab12c9bda50d1676d
Autor:
Christiane Pleuger, Dingding Ai, Minea L Hoppe, Laura T Winter, Daniel Bohnert, Dominik Karl, Stefan Guenther, Slava Epelman, Crystal Kantores, Monika Fijak, Sarina Ravens, Ralf Middendorff, Johannes U Mayer, Kate L Loveland, Mark Hedger, Sudhanshu Bhushan, Andreas Meinhardt
Publikováno v:
eLife, Vol 11 (2022)
The epididymis functions as transition zone for post-testicular sperm maturation and storage and faces contrasting immunological challenges, i.e. tolerance towards spermatozoa vs. reactivity against pathogens. Thus, normal organ function and integrit
Externí odkaz:
https://doaj.org/article/a41d07b05a714c4997aefbc4d9a009e5
Autor:
Sandra Bufe, Artur Zimmermann, Sarina Ravens, Immo Prinz, Laura Elisa Buitrago-Molina, Robert Geffers, Norman Woller, Florian Kühnel, Steven R. Talbot, Fatih Noyan, Michael Peter Manns, Heiner Wedemeyer, Matthias Hardtke-Wolenski, Elmar Jaeckel, Ana C. Davalos-Misslitz
Publikováno v:
Liver Cancer (2022)
Background: Checkpoint inhibitors act on exhausted CD8+ T cells and restore their effector function in chronic infections and cancer. The underlying mechanisms of action appear to differ between different types of cancer and are not yet fully underst
Externí odkaz:
https://doaj.org/article/965c2a4212154815948f7cc4a347137a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/37dd0a92875d4da28f49526b384615d3
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundVγ9Vδ2+ T cells are a major innate T cell subset in human peripheral blood. Their Vδ2+ VDJ-rearrangements are short and simple in the fetal thymus and gradually increase in diversity and CDR3 length along with development. So-called “p
Externí odkaz:
https://doaj.org/article/963c23cc59de42cd979e5168d4345c92