Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sarin Somers"'
Publikováno v:
SA Heart Journal, Vol 6, Iss 3, Pp 168-172 (2017)
Introduction: Tumour Necrosis Factor alpha (TNFα) contributes to cardiac dysfunction following ischaemia-reperfusion. Nonetheless, brief exposure to exogenous low doses of TNFα can mimic ischaemic preconditioning and thus be cardio-protective. The
Externí odkaz:
https://doaj.org/article/84d0d950263a4a23b28975884a299afd
Publikováno v:
Cardiovascular journal of Africa. 33
Ischaemic heart disease (IHD) is a leading cause of death worldwide. Understanding prosurvival signalling pathways that protect against ischaemia-reperfusion injury (IRI) may assist in the development of novel cardioprotective strategies against IHD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e0d1bdb591969701f5e1845f678f34b8
https://pubmed.ncbi.nlm.nih.gov/35687060
https://pubmed.ncbi.nlm.nih.gov/35687060
Autor:
Jonathan C King, Damian Hacking, Sarin Somers, Aqeela Imamdin, Samantha Hastie, Sarah Pedretti, Roisin Kelly-Laubscher, Tessa S. Stewart, Gerald J. Maarman, Sandrine Lecour
Publikováno v:
Cardiovascular Journal Of Africa. 25:118-123
Signal transducer and activator of transcription 3 (STAT-3) is a downstream mediator of many cardioprotective agents, most notably, of ischaemic pre- and postconditioning,1-5 i.e. protection brought about by repeated bouts of brief ischaemia before (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72893e26ef6414ddab3013171b3e001b
https://doi.org/10.5830/cvja-2014-016
https://doi.org/10.5830/cvja-2014-016
Publikováno v:
Journal of Pineal Research. 50:374-380
Epidemiological studies suggest that regular moderate consumption of red wine confers cardioprotection but the mechanisms involved in this effect remain unclear. Recent studies demonstrate the presence of melatonin in wine. We propose that melatonin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2fa7ecd559a6654e1f1596f3f897012
https://doi.org/10.1111/j.1600-079x.2010.00853.x
https://doi.org/10.1111/j.1600-079x.2010.00853.x
Publikováno v:
Cardiovascular Research. 84:201-208
Aims Ischaemic postconditioning (IPostC) is a powerful protective phenomenon that activates prosurvival intrinsic signalling cascades to limit reperfusion injury. We propose that IPostC confers its infarct-sparing effect via activation of the newly d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcac2d93a00771d0a2b2b362f1d2e21
https://doi.org/10.1093/cvr/cvp274
https://doi.org/10.1093/cvr/cvp274
Publikováno v:
Cardiovascular Research, Vol. 80, No 1 (2008) pp. 69-77
AIMS: Both cyclooxygenase-2 (COX-2) and the transcription factor signal transducer and activator of transcription 3 (Stat3) are involved in adaptive growth and survival of cardiomyocytes. In ventricular cardiomyocytes, prostaglandin E(2) (PGE(2)), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb39e9137188df2b6dd03f41f6329cac
https://doi.org/10.1093/cvr/cvn171
https://doi.org/10.1093/cvr/cvn171
Publikováno v:
Cardiovascular Research. 79:127-133
Aims During preconditioning by tumour necrosis factor-α (TNFα), activation of the signal transducer and activator of transcription-3 (STAT-3) but not Akt, is essential, whereas ischaemic cardiac preconditioning (IPC) requires both STAT-3 and Akt at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff8aa8de0218f099730fac753be00f0
https://doi.org/10.1093/cvr/cvn067
https://doi.org/10.1093/cvr/cvn067
Autor:
Barbara Huisamen, Graeme A. Deuchar, Lydia Lacerda, Sandrine Lecour, Naushaad Suleman, Lionel H. Opie, Sarin Somers
Publikováno v:
Circulation. 112:3911-3918
Background—We previously reported that tumor necrosis-factor-α (TNF-α) can mimic classic ischemic preconditioning (IPC) in a dose- and time-dependent manner. Because TNF-α activates the signal transducer and activator of transcription-3 (STAT-3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ac8de6316838ca37de991f5fa1b8f6
https://doi.org/10.1161/circulationaha.105.581058
https://doi.org/10.1161/circulationaha.105.581058
Autor:
Sarah Pedretti, Richard W. James, Damian Hacking, Lydia Lacerda, Miguel Frias, Sarin Somers, Sandrine Lecour, Lionel H. Opie
Publikováno v:
Atherosclerosis, Vol. 228, No 1 (2013) pp. 110-6
High density lipoproteins (HDL) protect against ischemia reperfusion injury (IRI). However the precise mechanisms are not clearly understood. The novel intrinsic prosurvival signaling pathway named survivor activating factor enhancement (SAFE) path i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d34630327e323e959c20559f6a5f68e
https://archive-ouverte.unige.ch/unige:74516
https://archive-ouverte.unige.ch/unige:74516
Following acute myocardial infarction (AMI), early reperfusion therapy with thrombolytic therapy or primary percutaneous coronary intervention therapy (PCI) is the best way to salvage the heart by limiting the infarct size and preserving the left ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec6af018d358d06b93e730757c672c63
https://doi.org/10.5772/30661
https://doi.org/10.5772/30661