Significant destabilization of human telomeric G-quadruplex upon peptide binding: dramatic effect of flanking bases

Autor: Nikita, Kundu, Taniya, Sharma, Sarvpreet, Kaur, Aman Kumar, Mahto, Rikeshwer, Prasad Dewangan, J, Shankaraswamy, Sarika, Saxena

Publikováno v: Journal of Biomolecular Structure and Dynamics. :1-9

Human telomere is composed of highly repeated hexanucleotide sequence TTAGGG and a 3' single-stranded DNA tail. Many telomere G4 topologies characterized at atomic level by X-ray crystallography and NMR studies. Until now, various small ligands devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61c63f57966f445a0cf06f70a53f442
https://doi.org/10.1080/07391102.2022.2116602

Recognition and unfolding of human telomeric G-quadruplex by short peptide binding identified from the HRDC domain of BLM helicase

Autor: Taniya Sharma, Nikita Kundu, Sarvpreet Kaur, Amlan Chakraborty, Aman Kumar Mahto, Rikeshwer Prasad Dewangan, Jadala Shankaraswamy, Sarika Saxena

Publikováno v: Sharma, T, Kundu, N, Kaur, S, Chakraborty, A, Mahto, A K, Dewangan, R P, Shankaraswamy, J & Saxena, S 2022, ' Recognition and unfolding of human telomeric G-quadruplex by short peptide binding identified from the HRDC domain of BLM helicase ', RSC Advances, vol. 12, pp. 21760-21769 . https://doi.org/10.1039/d2ra03646k

Research in recent decades has revealed that the guanine (G)-quadruplex secondary structure in DNA modulates a variety of cellular events that are mostly related to serious diseases. Systems capable of regulating DNA G-quadruplex structures would the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c75ddba5ef560ad5db7e7c50299699
https://doi.org/10.1039/d2ra03646k

Significant structural change in human c-Myc promoter G-quadruplex upon peptide binding in potassium

Autor: Nikita Kundu, Taniya Sharma, Sarvpreet Kaur, Mamta Singh, Vinit Kumar, Uttam Sharma, Aklank Jain, Jadala Shankaraswamy, Daisuke Miyoshi, Sarika Saxena

Publikováno v: RSC advances. 12(13)

We selected the G-quadruplex motif located in the nuclease-hypersensitive elements (NHE) III1 region of the c-Myc promoter and for the first time performed its interaction studies with a designed peptide (QW10). Our CD results showed that the peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1120e51ab284d6e3e4381743ed544847
https://pubmed.ncbi.nlm.nih.gov/35424772

Screening the binding potential of quercetin with parallel, antiparallel and mixed G-quadruplexes of human telomere and cancer protooncogenes using molecular docking approach

Autor: Nikita Kundu, Taniya Sharma, Priyansh Srivastava, Sarika Saxena, Shikhar Tyagi, Jadala Shankaraswamy, Sarvpreet Kaur

Publikováno v: SN Applied Sciences. 2

The bioinformatics analysis revealed that more than 400,000 DNA sequences within the human genome have the potential of forming G-quadruplex structures. Specifically, G-quadruplexes have been proved to be involved in the regulation of replication, DN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d69259b4c21b04e87b50eaecd1da509f
https://doi.org/10.1007/s42452-020-2280-8

Selective recognition of human telomeric G-quadruplex with designed peptide:Via hydrogen bonding followed by base stacking interactions

Autor: Shikhar Tyagi, Amlan Chakraborty, Sarika Saxena, Nikita Kundu, Sarvpreet Kaur, Taniya Sharma, Daisuke Miyoshi, Jadala Shankaraswamy

Publikováno v: Tyagi, S, Saxena, S, Kundu, N, Sharma, T, Chakraborty, A, Kaur, S, Miyoshi, D & Shankaraswamy, J 2019, ' Selective recognition of human telomeric G-quadruplex with designed peptide : Via hydrogen bonding followed by base stacking interactions ', RSC Advances, vol. 9, no. 69, pp. 40255-40262 . https://doi.org/10.1039/c9ra08761c

We described a novel synthetic peptide in which a glutamine residue binds through hydrogen bonding to a guanine-base and a trytophan residue intercalates with K+ resulting in stabilization of a human telomeric G-quadruplex with high selectivity over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fac807605898f16ad7780be17ad87b
https://www.research.manchester.ac.uk/portal/en/publications/selective-recognition-of-human-telomeric-gquadruplex-with-designed-peptide(84d46d46-9d21-47e6-a588-7e6cb979852b).html