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pro vyhledávání: '"Sari Sugahara"'
Autor:
Sari Sugahara, Yuki Ishino, Koki Sawada, Tsumugi Iwata, Yuta Shimanaka, Junken Aoki, Hiroyuki Arai, Nozomu Kono
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100443- (2023)
Phosphatidylserine (PS) is an acidic phospholipid that is involved in various cellular events. Heterologous dominant mutations have been identified in the gene encoding PS synthase 1 (PSS1) in patients with a congenital disease called Lenz-Majewski s
Externí odkaz:
https://doaj.org/article/65aeb195de3f4f9ab3916345f171d867
Autor:
Sari Sugahara, Beichen Xie, Olof Idevall-Hagren, Phuoc My Nguyen, Yingke Xu, Nikhil R. Gandasi
Publikováno v:
The Journal of Cell Biology
Nguyen et al. find that the PI(4)P phosphatase Sac2 localizes to insulin granules, where it controls granule docking to the plasma membrane. Loss of Sac2 results in impaired insulin secretion, and Sac2 mRNA levels are reduced in type 2 diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88824701b8935b525aef16adcb53439
https://doi.org/10.1083/jcb.201903121
https://doi.org/10.1083/jcb.201903121