Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sari Pappinen"'
Autor:
Johanna Tuunainen, Lasse Saloranta, Jouko Levijoki, Jenni Lindstedt, Jenni Lehtisalo, Sari Pappinen, Meri Ramela, Sami Virtanen, Heikki Joensuu
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 532 (2022)
Naloxone as emergency treatment for opioid overdosing can be administered via several routes. However, the available administration methods are invasive or may be associated with incomplete or slow naloxone absorption. We evaluated pharmacokinetics a
Externí odkaz:
https://doaj.org/article/7559035102a94e858d86ff1ed4786416
Autor:
Alex Mattinson, David Lindley, Helena Engman, Manthena V.S. Varma, Anh-Thu Nguyen-Trung, Binfeng Xia, Xavier Pepin, Linette Ruston, Wei Zhu, Bill van Osdol, Celine Ollier, David Good, Jonathan Brown, Laurent Boulu, Talia Flanagan, Olivier Nicolas, Staffan Berg, Shanoo Budhdeo, Aarti Patel, Jan Bevernage, Handan He, Sweta Modi, Richard Barker, Claire Jackson, Christer Tannergren, Xiojun Ren, Stephane Beilles, J. Matthew Wood, Johanna Laru, Pierre Daublain, Sara Carlert, Louis Henrion, Jean-Flaubert Nguefack, Gunilla Hanisch, Eva Karlsson, Wen Lin, Shruthi Vaidhyanathan, Robert Carr, Fan Wu, Jin Zhang, Amais Ahmad, James M. Mullin, Sari Pappinen, Andrea Moir, Ke Szeto, Christine Xu, Claire Patterson, David B. Turner, Guillaume Louit, Yuya Wang, Tycho Heimbach, Richard Lloyd, Frans Franek, Masoud Jamei, Christophe Tistaert, Bertil Abrahamsson, Kerstin Julia Schäfer, Leon Aarons, Shriram M. Pathak, Adam S. Darwich, Suet Wong, Dónal Murphy, Amin Rostami-Hodjegan, Timo Korjamo, Helena Thörn, Kartrin Schmid, Michael B. Bolger, Johanna Tuunainen, Mai Anh Nguyen
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 156:50-63
Oral drug absorption is a complex process depending on many factors, including the physicochemical properties of the drug, formulation characteristics and their interplay with gastrointestinal physiology and biology. Physiological-based pharmacokinet
Autor:
Richard Lloyd, Leon Aarons, Mark McAllister, Amitava Mitra, Chester Costales, Timo Korjamo, Maria Hammarberg, Helena Thörn, Carole Shardlow, Jussi Malkki, Adam S. Darwich, Tycho Heimbach, Achiel Van Peer, James M. Mullin, Jennifer B. Dressman, Johanna Laru, Dónal Murphy, Handan He, Jian Lin, Irina Mishenzon, Ke X. Szeto, Mei Wong, Peter Langguth, Bertil Abrahamsson, Carolin Hoft, Fan Wu, Mohammed Yasin, Olivier Nicolas, Manthena V.S. Varma, Alison Margolskee, Christer Tannergren, Edmund Kostewicz, Yan Pang, Shriram M. Pathak, Johanna Tuunainen, Constanze Hilgendorf, Sari Pappinen, Viera Lukacova, Charles J. Rotter, Jan Bevernage, Sweta Modi, Sergej Ramusovic, Simone Hansmann, Mai Anh Nguyen, Amin Rostami-Hodjegan, Eva Huehn, Michael B. Bolger, Jonathan Brown, Loic Laplanche, Christine Xu, Eva Karlsson, Sara Carlert, Pernilla Johansson, Florent Mazuir, Jeike Biewenga, Xavier Pepin, Hans Lennernäs, Aleksandra Galetin
Publikováno v:
Margolskee, A, Darwich, A, Aarons, L, Galetin, A, Rostami-Hochaghan, A, Carlert, S, Hammarberg, M, Hilgendorf, C, Johansson, P, Karlsson, E, Murphy, D, Tannergren, C, Thorn, H, Yasin, M, Mazuir, F, Nicolas, O, Ramusovic, S, Xu, C, Pathak, S, Korjamo, T, Laru, J, Malkki, J, Pappinen, S, Tuunainen, J, Dressman, J, Hansmann, S, Kostewicz, E, He, H, Heimbach, T, Wu, F, Hoft, C, Laplanche, L, Pang, Y, Bolger, M B, Huehn, E, Lukacova, V, Mullin, J M, Szeto, K X, Costales, C, Lin, J, McAllister, M, Modi, S, Rotter, C, Varma, M, Wong, M, Mitra, A, Bevernage, J, Biewenga, J, Van Peer, A, Lloyd, R, Shardlow, C, Langguth, P, Mishenzon, I, Nguyen, M A, Brown, J, Lennernas, H & Abrahamsson, B 2016, ' IMI – Oral Biopharmaceutics Tools project – Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results ', European Journal of Pharmaceutical Sciences . https://doi.org/10.1016/j.ejps.2016.10.036
Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation d
Autor:
Sari Pappinen, Sandra Nourry, Jouko Levijoki, Lasse Saloranta, Minja Hyttila-Hopponen, Pierre Montagne, Christophe Drieu La Rochelle
Publikováno v:
Cancer Research. 80:593-593
Background: Nausea and vomiting are common side effects of cancer therapies thereby seriously affecting the quality of life of patients. Therefore, the prevention or treatment of chemotherapy-induced nausea and vomiting has become an important part o
Autor:
Sari Pappinen, Arto Urtti
Publikováno v:
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement ISBN: 9783662478615
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::693cf365b6d3df6d1b723deac93caae6
https://doi.org/10.1007/978-3-662-47862-2_16
https://doi.org/10.1007/978-3-662-47862-2_16
Autor:
Sari Pappinen, Evgeny Pryazhnikov, Marjo Yliperttula, Arto Urtti, Marica B. Ericson, Leonard Khiroug
Publikováno v:
Journal of Controlled Release. 161:656-667
The outermost protective layer of the skin, the stratum corneum, is responsible for skin impermeability toward external medications and potentially harmful chemicals. Stratum corneum is the target for physical and chemical approaches to enhance drug
Autor:
Martin Hermansson, Marjukka Suhonen, Arto Urtti, Philip W. Wertz, Sari Pappinen, Pentti Somerharju, Judith Kuntsche
Publikováno v:
Pappinen, S, Hermansson, M, Kuntsche, J, Somerharju, P, Wertz, P, Urtti, A & Suhonen, M 2008, ' Comparison of rat epidermal keratinocyte organotypic culture (ROC) with intact human skin : lipid composition and thermal phase behavior of the stratum corneum ', BBA General Subjects, vol. 1778, no. 4, pp. 824-34 . https://doi.org/10.1016/j.bbamem.2007.12.019
The present report is a part of our continuing efforts to explore the utility of the rat epidermal keratinocyte organotypic culture (ROC) as an alternative model to human skin in transdermal drug delivery and skin irritation studies of new chemical e
Publikováno v:
Toxicology and Applied Pharmacology. 208:233-241
The potential of rat epidermal keratinocyte (REK) organotypic culture (ROC) with proper stratum corneum barrier as a model for screening skin irritants was evaluated. The test chemicals were selected from ECETOC database (1995) and the observed in vi
Autor:
Seppo Rönkkö, Marjukka Suhonen, Arto Urtti, Sari Pappinen, Alfred Fahr, Judith Kuntsche, Heike Bunjes
Publikováno v:
Kuntsche, J, Bunjes, H, Fahr, A, Pappinen, S, Rönkkö, S, Suhonen, M & Urtti, A 2008, ' Interaction of lipid nanoparticles with human epidermis and an organotypic cell culture model ', International Journal of Pharmaceutics, vol. 354, no. 1-2, pp. 180-95 . https://doi.org/10.1016/j.ijpharm.2007.08.028
Various lipid nanoparticle formulations were investigated with respect to (trans)dermal drug delivery with special regard to the mechanism of their effects on human and an organotypic cell culture epidermis. Potential alterations of stratum corneum l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79a23eac17970c97127ff721edd7ee3
https://portal.findresearcher.sdu.dk/da/publications/482c25ee-8e0d-4400-9ca3-28c49f0c580e
https://portal.findresearcher.sdu.dk/da/publications/482c25ee-8e0d-4400-9ca3-28c49f0c580e
Autor:
Sanna Pasonen-Seppänen, Sanna Tikkinen, Marjukka Suhonen, Arto Urtti, Sari Pappinen, Lasse Murtomäki
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 30(3-4)
The objective of this study was to evaluate the response of the rat epidermal keratinocyte organotypic culture (ROC) to permeation enhancers, and to compare these responses to those in human cadaver skin. Different concentrations of two mixtures for