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Akademický článek

Quantitative assessment of chlorine gas inhalation injury based on endoscopic OCT and spectral encoded interferometric microscope imaging with deep learning

Autor: Zhikai Zhu, Hyunmo Yang, Hongqiu Lei, Yusi Miao, George Philipopoulos, Melody Doosty, David Mukai, Yuchen Song, Jangwoen Lee, Sari Mahon, Matthew Brenner, Livia Veress, Carl White, Woonggyu Jung, Zhongping Chen

Publikováno v: APL Photonics, Vol 9, Iss 9, Pp 096109-096109-12 (2024)

Chlorine exposure can cause severe airway injuries. While the acute effects of chlorine inhalation are well-documented, the structural changes resulting from the post-acute, high-level chlorine exposure remain less understood. Airway sloughing is one

Externí odkaz: https://doaj.org/article/d212b551795d4963a10ee578fc707600

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Akademický článek

Mass Spectrometric Analysis of Purine Intermediary Metabolism Indicates Cyanide Induces Purine Catabolism in Rabbits

Autor: Jordan Morningstar, Jangwoen Lee, Sari Mahon, Matthew Brenner, Anjali K. Nath

Publikováno v: Metabolites, Vol 14, Iss 5, p 279 (2024)

Purines are the building blocks of DNA/RNA, energy substrates, and cofactors. Purine metabolites, including ATP, GTP, NADH, and coenzyme A, are essential molecules in diverse biological processes such as energy metabolism, signal transduction, and en

Externí odkaz: https://doaj.org/article/ed7d115e6d1541fa87b9e056c5f4089a

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Akademický článek

Glyoxylate protects against cyanide toxicity through metabolic modulation

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)

Abstract Although cyanide’s biological effects are pleiotropic, its most obvious effects are as a metabolic poison. Cyanide potently inhibits cytochrome c oxidase and potentially other metabolic enzymes, thereby unleashing a cascade of metabolic pe

Externí odkaz: https://doaj.org/article/cb54f482aaef485c9442a4f1d31f3076

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Akademický článek

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.

Autor: Patrick Y Sips, Xu Shi, Gabriel Musso, Anjali K Nath, Yanbin Zhao, Jason Nielson, Jordan Morningstar, Amy E Kelly, Brittney Mikell, Eva Buys, Vikhyat Bebarta, Jared Rutter, V Jo Davisson, Sari Mahon, Matthew Brenner, Gerry R Boss, Randall T Peterson, Robert E Gerszten, Calum A MacRae

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0193889 (2018)

Cyanide is a potent toxic agent, and the few available antidotes are not amenable to rapid deployment in mass exposures. As a result, there are ongoing efforts to exploit different animal models to identify novel countermeasures. We have created a pi

Externí odkaz: https://doaj.org/article/dfb36b2dc03449c094e1cb342366fade

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Akademický článek

Faraday Waves-Based Integrated Ultrasonic Micro-Droplet Generator and Applications

Autor: Chen S. Tsai, Rong W. Mao, Shirley C. Tsai, Kaveh Shahverdi, Yun Zhu, Shih K. Lin, Yu-Hsiang Hsu, Gerry Boss, Matt Brenner, Sari Mahon, Gerald C. Smaldone

Publikováno v: Micromachines, Vol 8, Iss 2, p 56 (2017)

An in-depth review on a new ultrasonic micro-droplet generator which utilizes megahertz (MHz) Faraday waves excited by silicon-based multiple Fourier horn ultrasonic nozzles (MFHUNs) and its potential applications is presented. The new droplet genera

Externí odkaz: https://doaj.org/article/1f1ec22bcb454a57a08d542b0205fded

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Intramuscular administration of glyoxylate rescues swine from lethal cyanide poisoning and ameliorates the biochemical sequalae of cyanide intoxication

Autor: Vik S Bebarta, Xu Shi, Shunning Zheng, Tara B Hendry-Hofer, Carter C Severance, Matthew M Behymer, Gerry R Boss, Sari Mahon, Matthew Brenner, Gregory T Knipp, Vincent Jo Davisson, Randall T Peterson, Calum A MacRae, Jared Rutter, Robert E Gerszten, Anjali K Nath

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology, vol 191, iss 1

Cyanide—a fast-acting poison—is easy to obtain given its widespread use in manufacturing industries. It is a high-threat chemical agent that poses a risk of occupational exposure in addition to being a terrorist agent. FDA-approved cyanide antido

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a5665cbc5902db4af2577274e5b564
https://doi.org/10.1093/toxsci/kfac116

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Methyl mercaptan gas: mechanisms of toxicity and demonstration of the effectiveness of cobinamide as an antidote in mice and rabbits

Autor: George P. Philipopoulos, John Tat, Adriano Chan, Jingjing Jiang, David Mukai, Tanya Burney, Melody Doosty, Sari Mahon, Hemal H. Patel, Carl W. White, Matthew Brenner, Jangwoen Lee, Gerry R. Boss

Publikováno v: Clinical toxicology (Philadelphia, Pa.), vol 60, iss 5
Clin Toxicol (Phila)

Methyl mercaptan (CH3SH) is a colorless, toxic gas with potential for occupational exposure and used as a weapon of mass destruction. Inhalation at high concentrations can result in dyspnea, hypoventilation, seizures, and death. No specific methyl me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb5b060b300a4598c87dd0d8b9a9c46
https://doi.org/10.1080/15563650.2021.2017949

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Development of a Fluorescence-Based Sensor for Rapid Diagnosis of Cyanide Exposure

Autor: Raj K. Bhandari, Robert P. Oda, Gary A. Rockwood, Sari Mahon, Randy Jackson, Brian A. Logue, Matthew Brenner

Publikováno v: Analytical Chemistry
Jackson, R; Oda, RP; Bhandari, RK; Mahon, SB; Brenner, M; Rockwood, GA; et al.(2014). Development of a fluorescence-based sensor for rapid diagnosis of cyanide exposure. Analytical Chemistry, 86(3), 1845-1852. doi: 10.1021/ac403846s. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6dz6b24s

Although commonly known as a highly toxic chemical, cyanide is also an essential reagent for many industrial processes in areas such as mining, electroplating, and synthetic fiber production. The "heavy" use of cyanide in these industries, along with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bedfb81cff0d2b644fbbe050dcde4a49
https://doi.org/10.1021/ac403846s

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A countermeasure development pipeline

Autor: Calum A, MacRae, Gerry, Boss, Matthew, Brenner, Robert E, Gerszten, Sari, Mahon, Randall T, Peterson

Publikováno v: Annals of the New York Academy of Sciences. 1378(1)

We have developed an integrated pipeline for countermeasure discovery that, under the auspices of the National Institutes of Health Countermeasures Against Chemical Threats network, is one of the few efforts within academia that by design spans the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e70de93fe6d949518e496221895973e0
https://pubmed.ncbi.nlm.nih.gov/27737495

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