Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sari Fishman"'
Publikováno v:
Andrologia. 54
Adenosine plays a major role in erection by binding to its receptors and activating pathways resulting in increased arterial blood flow and intracavernosal pressure (ICP). CF602, an allosteric modulator of the A3 adenosine receptor (A3AR), increases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95199d558363c202b70146a1578f7f52
https://doi.org/10.1111/and.14498
https://doi.org/10.1111/and.14498
Autor:
Noa Chetrit, Pnina Fishman, William D Kerns, Kenneth A. Jacobson, Irina S. Barequet, Motti Farbstein, Sara Bar Yehuda, Hanna J. Garzozi, Gil Sartani, Michael H. Silverman, Gilad Litvin, Erez Bakshi, Oren Tomkins, David Zadok, Ilan Cohn, Zivit Harpaz, Fanni Segev, David Bristol, Sari Fishman, David Varssano, Isaac Avni
Publikováno v:
Ophthalmology. 117:1287-1293
Objective To explore the safety and efficacy of CF101, an A 3 adenosine receptor agonist, in patients with moderate to severe dry eye syndrome. Design Phase 2, multicenter, randomized, double-masked, placebo-controlled, parallel-group study. Particip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892ce353f39cb2ceabc184845b3441f6
https://doi.org/10.1016/j.ophtha.2009.11.029
https://doi.org/10.1016/j.ophtha.2009.11.029
Autor:
Emil A Dimitrov, ra Gurman-Balbir, Ameet Pispati, rov Oparanov, Zivit Harpaz, Krasimira M Shimbova, Tatiana Reitblat, Motti Farbstein, David Bristol, Pnina Fishman, BR Bagaria, Michael H Silverman, Girish Bhatia, Alex, Mariyana K Mihaylova, Rumen M Stoilov, Sari Fishman, Shira Cohen, Boytcho Aleks, Rodina N Licheva
Publikováno v:
Immunome Research. 11
Background: CF101, an orally bioavailable A3 adenosine receptor (A3AR) agonist, demonstrated very good safety and anti-inflammatory effect in Phase II clinical studies in patients with rheumatoid arthritis (RA) and psoriasis. A3AR expression level in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98c13817adb71fcb701947bd8d174b03
https://doi.org/10.4172/1745-7580.1000087
https://doi.org/10.4172/1745-7580.1000087
Autor:
Isaac, Avni, Hanna J, Garzozi, Irina S, Barequet, Fanni, Segev, David, Varssano, Gil, Sartani, Noa, Chetrit, Erez, Bakshi, David, Zadok, Oren, Tomkins, Gilad, Litvin, Kenneth A, Jacobson, Sari, Fishman, Zivit, Harpaz, Motti, Farbstein, Sara Bar, Yehuda, Michael H, Silverman, William D, Kerns, David R, Bristol, Ilan, Cohn, Pnina, Fishman
To explore the safety and efficacy of CF101, an A(3) adenosine receptor agonist, in patients with moderate to severe dry eye syndrome.Phase 2, multicenter, randomized, double-masked, placebo-controlled, parallel-group study.Sixty-eight patients compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9d5658962bd6a6636faf5f51c38010f3
https://europepmc.org/articles/PMC3668568/
https://europepmc.org/articles/PMC3668568/
Autor:
Michael H, Silverman, Vibeke, Strand, Doron, Markovits, Menachem, Nahir, Tatiana, Reitblat, Yair, Molad, Itzhak, Rosner, Michael, Rozenbaum, Reuven, Mader, Muhamad, Adawi, Dan, Caspi, Moshe, Tishler, Pnina, Langevitz, Alan, Rubinow, Joshua, Friedman, Lesly, Green, Amir, Tanay, Avivit, Ochaion, Shira, Cohen, William D, Kerns, Ilan, Cohn, Sari, Fishman-Furman, Motti, Farbstein, Sara Bar, Yehuda, Pnina, Fishman
Publikováno v:
The Journal of rheumatology. 35(1)
Adenosine exerts antiinflammatory effects via activation of the A3 adenosine receptor (A3AR), a Gi protein-associated cell-surface receptor, overexpressed in synovial tissue and peripheral blood mononuclear cells (PBMC) in patients with active rheuma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83f5262078123f93e43ef08409fe454d
https://pubmed.ncbi.nlm.nih.gov/18050382
https://pubmed.ncbi.nlm.nih.gov/18050382
Publikováno v:
Annals of the Rheumatic Diseases. 74:215.1-215
Background The Gi protein associated A 3 adenosine receptor (A 3 AR), is over- expressed in inflammatory cells and this high expression is also reflected in the peripheral blood mononuclear cells (PBMCs) of patients with autoimmune inflammatory disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f78024f799aa5de96bbe51f9106812d
https://doi.org/10.1136/annrheumdis-2015-eular.1605
https://doi.org/10.1136/annrheumdis-2015-eular.1605
CF102 for the Treatment of Hepatocellular Carcinoma: A Phase I/II, Open-Label, Dose-Escalation Study
Autor:
Pnina Fishman, Ofer Benjaminov, William D Kerns, Barak Singer, Salomon M. Stemmer, Motti Farbstein, Renana Petoka, Sara Bar Yehuda, Noa Beatrice Ciuraru, Gal Medalia, Sari Fishman, Shira Cohen, Zivit Harpaz, Michael H Silverman
Publikováno v:
The Oncologist. 18:25-26
Background. The A3 adenosine receptor (A3AR) is overexpressed in the tumor and in the peripheral blood mononuclear cells of patients with hepatocellular carcinoma (HCC). The orally active drug candidate CF102, an A3AR agonist, induces apoptosis of HC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e032a8fc2d066c3849ebdbeb9fea59
https://doi.org/10.1634/theoncologist.2012-0211
https://doi.org/10.1634/theoncologist.2012-0211
Autor:
O. Binyaminov, P. Fishman, Zivit Harpaz, Sari Fishman, Salomon M. Stemmer, William D Kerns, Michael H. Silverman, Gal Medalia, S. Bar Yehuda, Motti Farbstein
Publikováno v:
European Journal of Cancer Supplements. 8:122
Methods: The objectives of this trial are to evaluate the safety and pharmacokinetic (PK) behavior of CF102 in HCC patients. Utilizing a “3+3” design, successive cohorts of patients with advanced HCC were enrolled at CF 102 doses of 1, 5, or 25 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4afbdfdcfdf480226f1e30c222686c
https://doi.org/10.1016/s1359-6349(10)72091-7
https://doi.org/10.1016/s1359-6349(10)72091-7
Autor:
Lea Madi, Shira Cohn, Alexander Reitblat, A. Zabutti, Yair Levi, Pnina Langevitz, Tatiana Reitblat, G. Perez-Liz, Yair Molad, Sari Fishman-Furman, Pnina Fishman, Avivit Ochaion, Luis Del Valle, Sara Bar-Yehuda, Motti Farbstein, Reuven Mader, Faina Barer, Howard Amital, Moshe Tishler
Publikováno v:
Arthritis Research & Therapy. 8:R169
Methotrexate (MTX) exerts an anti-inflammatory effect via its metabolite adenosine, which activates adenosine receptors. The A3 adenosine receptor (A3AR) was found to be highly expressed in inflammatory tissues and peripheral blood mononuclear cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f94d8479eac65739bd553c694ecfbe87
https://doi.org/10.1186/ar2078
https://doi.org/10.1186/ar2078