Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Sargent, Bruce J"'
Autor:
Dejian Xie, Gillian Grafton, Alexander Roberts, Nicholas A. Moore, Jinkun Huang, Nicholas M. Barnes, Catherine A. Brady, Kristian Brock, Shuang Liu, Andrew D. Powell, Zania Stamataki, Omar S. Qureshi, A.J Cooper, Chunlin Chen, Peter R. Guzzo, Sargent Bruce J, David D. Manning
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:122-134
The 5-hydroxytryptamine (5-HT) (serotonin) 5-HT3 receptor represents a clinical target for antagonists to deliver symptomatic relief to patients with diarrhea-predominant irritable bowel syndrome (IBS-d) or carcinoid syndrome. Unfortunately, this pha
Autor:
Sargent, Bruce J, Henderson, Alan J
Publikováno v:
In Current Opinion in Pharmacology 2011 11(1):52-58
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Neurobiology of Disease, Vol 61, Iss, Pp 47-54 (2014)
Clinical development of drugs for CNS disorders can be a challenging and risky endeavor. In this article we look at the steps required to move a preclinical candidate compound into clinical development. We use the case study of ALB-127158(a), an MCH1
Autor:
Alan J. Henderson, Sargent Bruce J
Publikováno v:
Current Opinion in Pharmacology. 11:52-58
Serotonin is known to have anorectic properties through centrally acting mechanisms. Three serotonin receptors have been implicated in mediating these effects: 5-HT(1B), 5-HT(2C) and 5-HT(6). Hypophagic effects are elicited through agonism of the for
Autor:
Marc L. Reitman, Cheng Guo, Theresa M. Kelly, Constantin Tamvakopoulos, Joseph M. Metzger, Tianying Jian, Howard Y. Chen, Arthur A. Patchett, Oksana C. Palyha, Alison M. Strack, Allan J. Goodman, Ravi P. Nargund, Peter H. Dobbelaar, Yanqing Kan, Mark Hadden, Larry Yet, Peter R. Guzzo, Qianping Peng, Linus S. Lin, Shuwen He, Lauren P. Shearman, Alan J. Henderson, Carina P. Tan, Sargent Bruce J, Xiao-Ming Guan, Scott D. Feighner, Iyassu K. Sebhat, Jie Pan, Jian Liu, Donald J. Marsh, Matthew J. Wyvratt, Andrew D. Howard, Megan Ruenz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1913-1917
We report SAR studies on a novel non-peptidic bombesin receptor subtype-3 (BRS-3) agonist lead series derived from high-throughput screening hit RY-337. This effort led to the discovery of compound 22e with significantly improved potency at both rode
Publikováno v:
CNS Drug Reviews. 7:146-171
BTS 72664, (R)-7-[1-(4-chlorophenoxy)]ethyl]-1,2,4-triazolo(1,5-alpha)pyrimidine, was identified as a drug development candidate from a research program designed to discover novel, broad-spectrum, non-sedative anticonvulsant drugs. BTS 72664 antagoni
Autor:
Min Hu, Snjezana Lelas, Michael Sinz, Yuri L. Khmelnitsky, Dennis Milanowski, Anne Payen-Fornicola, Matthew Isherwood, Dalton King, Nicholas Holman, Carla Hassler, Wenge Cui, Jonathan O’Connell, Yuh-Lin Yang, Ulhas Bhatt, Nicholas J. Lodge, Yu-Wen Li, Roy Haskell, John E. Macor, Sargent Bruce J, Kim A. Johnson, Linda Fleming, Stephen P. Adams, Vadim V. Mozhaev, Sarah M. Ebeltoft, Shuang Liu, Thaddeus F. Molski, Sambandam Aruna, Richard E. Olson, Congxiang Zha, Robert L. Bertekap, Bruce F. Molino, Wendy Clarke, Robert Zaczek, Anthony D. Pechulis, Michael Herr, Peter R. Guzzo, Larry Yet, Alicia Ng, Anitra F. Orie, Ian C. Cotterill, Kassoum Nacro
Publikováno v:
ACS medicinal chemistry letters. 5(7)
A series of 4-bicyclic heteroaryl 1,2,3,4-tetrahydroisoquinoline inhibitors of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) was discovered. The synthesis and structure-activity relationship (SAR)
Publikováno v:
Tetrahedron. 54:9603-9612
Oxidation of β-aryl- and β-heteroarylpyruvic acids using sodium perborate tetrahydrate (SPB) in aqueous solution at ambient temperature gives the corresponding arylacetic acids in good yield (68–86%). The mild conditions are convenient for the pr
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.