Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Sarel J. Fleishman"'
Autor:
Fanindra Kumar Deshmukh, Gili Ben-Nissan, Maya A. Olshina, Maria G. Füzesi-Levi, Caley Polkinghorn, Galina Arkind, Yegor Leushkin, Irit Fainer, Sarel J. Fleishman, Dan Tawfik, Michal Sharon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Controlled degradation of proteins is necessary for ensuring their abundance and sustaining a healthy and accurately functioning proteome. One of the degradation routes involves the uncapped 20S proteasome, which cleaves proteins with a part
Externí odkaz:
https://doaj.org/article/efa8f7774d4c40b7b1bee774b5fa6164
Autor:
Jonathan Yaacov Weinstein, Carlos Martí-Gómez, Rosalie Lipsh-Sokolik, Shlomo Yakir Hoch, Demian Liebermann, Reinat Nevo, Haim Weissman, Ekaterina Petrovich-Kopitman, David Margulies, Dmitry Ivankov, David M. McCandlish, Sarel J. Fleishman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Mutations in a protein active site can lead to dramatic and useful changes in protein activity. The active site, however, is sensitive to mutations due to a high density of molecular interactions, substantially reducing the likelihood of obt
Externí odkaz:
https://doaj.org/article/0a700fa200fc4fecb09ddd2b73e61207
Autor:
Iris D. Zelnik, Beatriz Mestre, Jonathan J. Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel J. Fleishman, Anthony H. Futerman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-6 (2023)
Abstract Until now, membrane-protein stabilization has relied on iterations of mutations and screening. We now validate a one-step algorithm, mPROSS, for stabilizing membrane proteins directly from an AlphaFold2 model structure. Applied to the lipid-
Externí odkaz:
https://doaj.org/article/014e0396f55e4922b17b62df905dfa74
Autor:
Pascal D. Vos, Giulia Rossetti, Jessica L. Mantegna, Stefan J. Siira, Andrianto P. Gandadireja, Mitchell Bruce, Samuel A. Raven, Olga Khersonsky, Sarel J. Fleishman, Aleksandra Filipovska, Oliver Rackham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The ability to alter the genomes of living cells is key to understanding how genes influence the functions of organisms and will be critical to modify living systems for useful purposes. Here, the authors use computational design to discover Cas9 enz
Externí odkaz:
https://doaj.org/article/42738fae0b8a437eab42e9af9c83d4ca
Autor:
Dmitri Nikitin, Jan Mican, Martin Toul, David Bednar, Michaela Peskova, Patricia Kittova, Sandra Thalerova, Jan Vitecek, Jiri Damborsky, Robert Mikulik, Sarel J. Fleishman, Zbynek Prokop, Martin Marek
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1366-1377 (2022)
Cardio- and cerebrovascular diseases are leading causes of death and disability, resulting in one of the highest socio-economic burdens of any disease type. The discovery of bacterial and human plasminogen activators and their use as thrombolytic dru
Externí odkaz:
https://doaj.org/article/190a12128de241f4a06bec66f667421d
Autor:
Ellen M. Adams, Simone Pezzotti, Jonas Ahlers, Maximilian Rüttermann, Maxim Levin, Adi Goldenzweig, Yoav Peleg, Sarel J. Fleishman, Irit Sagi, Martina Havenith
Publikováno v:
JACS Au, Vol 1, Iss 7, Pp 1076-1085 (2021)
Externí odkaz:
https://doaj.org/article/678d581f417f468695ec2be3bec3b018
Autor:
Olga Khersonsky, Sarel J. Fleishman
Publikováno v:
BioDesign Research, Vol 2022 (2022)
The overarching goal of computational protein design is to gain complete control over protein structure and function. The majority of sophisticated binders and enzymes, however, are large and exhibit diverse and complex folds that defy atomistic desi
Externí odkaz:
https://doaj.org/article/70858688440c450cbd3ae6145a9f6c2a
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
To enable a sustainable supply of chemicals, novel biotechnological solutions are required that replace the reliance on fossil resources. One potential solution is to utilize tailored biosynthetic modules for the metabolic conversion of CO2 or organi
Externí odkaz:
https://doaj.org/article/d1729413e084415b81c8b1c99cc2d532
Autor:
Ravit Netzer, Dina Listov, Rosalie Lipsh, Orly Dym, Shira Albeck, Orli Knop, Colin Kleanthous, Sarel J. Fleishman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The molecular basis of ultrahigh specificity in protein-protein interactions remains obscure. The authors present a computational method to design atomically accurate new pairs exhibiting >100,000-fold specificity switches, generating a large and com
Externí odkaz:
https://doaj.org/article/9939e24b02bd4d13a295f4878802d25a
Autor:
Adva Mechaly, Eran Diamant, Ron Alcalay, Alon Ben David, Eyal Dor, Amram Torgeman, Ada Barnea, Meni Girshengorn, Lilach Levin, Eyal Epstein, Ariel Tennenhouse, Sarel J. Fleishman, Ran Zichel, Ohad Mazor
Publikováno v:
Antibodies, Vol 11, Iss 1, p 21 (2022)
Botulinum neurotoxin type E (BoNT/E), the fastest acting toxin of all BoNTs, cleaves the 25 kDa synaptosomal-associated protein (SNAP-25) in motor neurons, leading to flaccid paralysis. The specific detection and quantification of the BoNT/E-cleaved
Externí odkaz:
https://doaj.org/article/797ceaec67d04932a171fe9845595a57