Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Sarel J Fleishman"'
Autor:
Assaf Elazar, Nicholas J Chandler, Ashleigh S Davey, Jonathan Y Weinstein, Julie V Nguyen, Raphael Trenker, Ryan S Cross, Misty R Jenkins, Melissa J Call, Matthew E Call, Sarel J Fleishman
Publikováno v:
eLife, Vol 11 (2022)
De novo-designed receptor transmembrane domains (TMDs) present opportunities for precise control of cellular receptor functions. We developed a de novo design strategy for generating programmed membrane proteins (proMPs): single-pass α-helical TMDs
Externí odkaz:
https://doaj.org/article/4c88ae4a5ecb43b5a0ea6b73ec898c18
Autor:
Shira Warszawski, Aliza Borenstein Katz, Rosalie Lipsh, Lev Khmelnitsky, Gili Ben Nissan, Gabriel Javitt, Orly Dym, Tamar Unger, Orli Knop, Shira Albeck, Ron Diskin, Deborah Fass, Michal Sharon, Sarel J Fleishman
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 8, p e1007207 (2019)
Antibodies developed for research and clinical applications may exhibit suboptimal stability, expressibility, or affinity. Existing optimization strategies focus on surface mutations, whereas natural affinity maturation also introduces mutations in t
Externí odkaz:
https://doaj.org/article/8ac5f6b2550b469daacf44c1a218e827
Autor:
Sarel J Fleishman, Andrew Leaver-Fay, Jacob E Corn, Eva-Maria Strauch, Sagar D Khare, Nobuyasu Koga, Justin Ashworth, Paul Murphy, Florian Richter, Gordon Lemmon, Jens Meiler, David Baker
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20161 (2011)
Macromolecular modeling and design are increasingly useful in basic research, biotechnology, and teaching. However, the absence of a user-friendly modeling framework that provides access to a wide range of modeling capabilities is hampering the wider
Externí odkaz:
https://doaj.org/article/ea92211299a74bdd97cf7ac76448c659
Autor:
Fanindra Kumar Deshmukh, Gili Ben-Nissan, Maya A. Olshina, Maria G. Füzesi-Levi, Caley Polkinghorn, Galina Arkind, Yegor Leushkin, Irit Fainer, Sarel J. Fleishman, Dan Tawfik, Michal Sharon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Controlled degradation of proteins is necessary for ensuring their abundance and sustaining a healthy and accurately functioning proteome. One of the degradation routes involves the uncapped 20S proteasome, which cleaves proteins with a part
Externí odkaz:
https://doaj.org/article/efa8f7774d4c40b7b1bee774b5fa6164
Autor:
Jonathan Yaacov Weinstein, Carlos Martí-Gómez, Rosalie Lipsh-Sokolik, Shlomo Yakir Hoch, Demian Liebermann, Reinat Nevo, Haim Weissman, Ekaterina Petrovich-Kopitman, David Margulies, Dmitry Ivankov, David M. McCandlish, Sarel J. Fleishman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Mutations in a protein active site can lead to dramatic and useful changes in protein activity. The active site, however, is sensitive to mutations due to a high density of molecular interactions, substantially reducing the likelihood of obt
Externí odkaz:
https://doaj.org/article/0a700fa200fc4fecb09ddd2b73e61207
Autor:
Iris D. Zelnik, Beatriz Mestre, Jonathan J. Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel J. Fleishman, Anthony H. Futerman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-6 (2023)
Abstract Until now, membrane-protein stabilization has relied on iterations of mutations and screening. We now validate a one-step algorithm, mPROSS, for stabilizing membrane proteins directly from an AlphaFold2 model structure. Applied to the lipid-
Externí odkaz:
https://doaj.org/article/014e0396f55e4922b17b62df905dfa74
Some protein binding pairs exhibit extreme specificities that functionally insulate them from homologs. Such pairs evolve mostly by accumulating single-point mutations, and mutants are selected if their affinity exceeds the threshold required for fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f80f3d0a37b28c8c2e4e1fc2fb0406d
https://doi.org/10.21203/rs.3.rs-2836905/v1
https://doi.org/10.21203/rs.3.rs-2836905/v1
Autor:
Olga Khersonsky, Moshe Goldsmith, Irina Zaretsky, Shelly Rogotner, Orly Dym, Tamar Unger, Meital Yona, Sarel J. Fleishman
Albumin is the most abundant protein in the blood serum of mammals and has essential carrier and physiological roles. Albumins are also used in a wide variety of molecular and cellular experiments and in the cultured-meat industry. Despite their impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::959f51fe969ca34576e6d78ee1df7e4b
https://doi.org/10.1101/2023.03.28.534334
https://doi.org/10.1101/2023.03.28.534334
Autor:
Sarka Pokorna, Olga Khersonsky, Rosalie Lipsh‐Sokolik, Adi Goldenzweig, Rebekka Nielsen, Yacov Ashani, Yoav Peleg, Tamar Unger, Shira Albeck, Orly Dym, Asa Tirosh, Rana Tarayra, Michaël Hocquemiller, Ralph Laufer, Shifra Ben‐Dor, Israel Silman, Joel L. Sussman, Sarel J. Fleishman, Anthony H. Futerman
Publikováno v:
The FEBS Journal.
Autor:
null Sarka Pokorna, null Olga Khersonsky, null Rosalie Lipsh‐Sokolik, null Adi Goldenzweig, null Rebekka Nielsen, null Yacov Ashani, null Yoav Peleg, null Tamar Unger, null Shira Albeck, null Orly Dym, null Asa Tirosh, null Rana Tarayra, null Michaël Hocquemiller, null Ralph Laufer, null Shifra Ben‐Dor, null Israel Silman, null Joel L. Sussman, null Sarel J. Fleishman, null Anthony H. Futerman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e00b62895e63a5c64c1ba12b351bfbf
https://doi.org/10.1111/febs.16758/v2/response1
https://doi.org/10.1111/febs.16758/v2/response1