Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Sarel F. Malan"'
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100211- (2024)
This study presents a series of coumarin nitric oxide donor hybrids that were synthesized, and characterized using FT-IR, H NMR, C NMR, and HR-MS techniques. Initial screening for anti-tubercular activity was conducted against Mycolicibacterium smegm
Externí odkaz:
https://doaj.org/article/d7410d0bff874538b61d6dc8f137ddd5
Autor:
Sheunopa C. Mzezewa, Sylvester I. Omoruyi, Luke S. Zondagh, Sarel F. Malan, Okobi E. Ekpo, Jacques Joubert
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1606-1620 (2021)
Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer’s disease (AD). Coumarin derivatives serve as a good starting point for designing MTDLs due to their inherent inhibition of monoamine oxidase (MAO) and c
Externí odkaz:
https://doaj.org/article/d4af1050d3ea43109b836387a213883e
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/743aafd69bdb4413bb3d46aa65f08594
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1596-1605 (2020)
A series of multi-target directed edaravone derivatives bearing N-benzyl pyridinium moieties were designed and synthesised. Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited po
Externí odkaz:
https://doaj.org/article/88bdb8b280ef4a81a2e3418a1a1a0b0f
Autor:
Erika Kapp, Jacques Joubert, Samantha L. Sampson, Digby F. Warner, Ronnett Seldon, Audrey Jordaan, Margaretha de Vos, Rajan Sharma, Sarel F. Malan
Publikováno v:
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2021 (2021)
Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective survival of mycobacteria with dr
Externí odkaz:
https://doaj.org/article/88c1c1f46efe44879b93b4033a581dc2
Publikováno v:
Molecules, Vol 25, Iss 19, p 4552 (2020)
The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development of neurodegenerative disorder
Externí odkaz:
https://doaj.org/article/afe20d9df6254491a07b9b61a9a6889e
Publikováno v:
Molecules, Vol 23, Iss 7, p 1678 (2018)
Dengue fever is a major public health concern in many tropical and sub-tropical regions. The development of agents that are able to inhibit the dengue virus (DENV) is therefore of utmost importance. This study focused on the synthesis of dual acting
Externí odkaz:
https://doaj.org/article/898692f36fce467f8ddae0071f47339e
Publikováno v:
Molecules, Vol 23, Iss 2, p 308 (2018)
In order to utilize the neuroprotective properties of polycyclic cage compounds, and explore the NO-donating ability of nitrophenyl groups, an array of compounds was synthesized where the different nitrophenyl groups were appended on oxa and aza-brid
Externí odkaz:
https://doaj.org/article/125aaf300d9a49e28123255b55ccbd09
Autor:
Erika Kapp, Hanri Visser, Samantha L. Sampson, Sarel F. Malan, Elizabeth M. Streicher, Germaine B. Foka, Digby F. Warner, Sylvester I. Omoruyi, Adaze B. Enogieru, Okobi E. Ekpo, Frank T. Zindo, Jacques Joubert
Publikováno v:
Molecules, Vol 22, Iss 10, p 1644 (2017)
A medium-throughput screen using Mycobacterium tuberculosis H37Rv was employed to screen an in-house library of structurally diverse compounds for antimycobacterial activity. In this initial screen, eleven 7-substituted coumarin derivatives with conf
Externí odkaz:
https://doaj.org/article/40c80158149344729d27ffcd8ef7f00a
Publikováno v:
Molecules, Vol 21, Iss 1, p 104 (2016)
In light of current resistance to antimalarial drugs, there is a need to discover new classes of antimalarial agents with unique mechanisms of action. Identification of unique scaffolds from natural products with in vitro antiplasmodial activities ma
Externí odkaz:
https://doaj.org/article/abbeff4f03354137b43428657eaaa38a