Zobrazeno 1 - 10
of 703
pro vyhledávání: '"Sarel, J."'
Publikováno v:
Journal of Tropical Medicine, Vol 2024 (2024)
Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization (WHO), an estimated 247 million
Externí odkaz:
https://doaj.org/article/9bed814123534b6faf1a4a389c6b0b40
Autor:
Fanindra Kumar Deshmukh, Gili Ben-Nissan, Maya A. Olshina, Maria G. Füzesi-Levi, Caley Polkinghorn, Galina Arkind, Yegor Leushkin, Irit Fainer, Sarel J. Fleishman, Dan Tawfik, Michal Sharon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Controlled degradation of proteins is necessary for ensuring their abundance and sustaining a healthy and accurately functioning proteome. One of the degradation routes involves the uncapped 20S proteasome, which cleaves proteins with a part
Externí odkaz:
https://doaj.org/article/efa8f7774d4c40b7b1bee774b5fa6164
Autor:
Jonathan Yaacov Weinstein, Carlos Martí-Gómez, Rosalie Lipsh-Sokolik, Shlomo Yakir Hoch, Demian Liebermann, Reinat Nevo, Haim Weissman, Ekaterina Petrovich-Kopitman, David Margulies, Dmitry Ivankov, David M. McCandlish, Sarel J. Fleishman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Mutations in a protein active site can lead to dramatic and useful changes in protein activity. The active site, however, is sensitive to mutations due to a high density of molecular interactions, substantially reducing the likelihood of obt
Externí odkaz:
https://doaj.org/article/0a700fa200fc4fecb09ddd2b73e61207
Autor:
Iris D. Zelnik, Beatriz Mestre, Jonathan J. Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel J. Fleishman, Anthony H. Futerman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-6 (2023)
Abstract Until now, membrane-protein stabilization has relied on iterations of mutations and screening. We now validate a one-step algorithm, mPROSS, for stabilizing membrane proteins directly from an AlphaFold2 model structure. Applied to the lipid-
Externí odkaz:
https://doaj.org/article/014e0396f55e4922b17b62df905dfa74
Autor:
Khersonsky, Olga, Goldsmith, Moshe, Zaretsky, Irina, Hamer-Rogotner, Shelly, Dym, Orly, Unger, Tamar, Yona, Meital, Fridmann-Sirkis, Yael, Fleishman, Sarel J.
Publikováno v:
In Journal of Molecular Biology 1 September 2023 435(17)
Akademický článek
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Akademický článek
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Publikováno v:
South African Journal of Physiotherapy, Vol 79, Iss 1, Pp e1-e13 (2023)
Background: The extension of medicine prescription rights to other healthcare providers was proposed to reduce pharmacotherapeutic service delivery challenges in the South African healthcare sector. The scope of practice of physiotherapists is being
Externí odkaz:
https://doaj.org/article/34102a8871f14de098502e99e5cd1f45