Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sarcoma, Ewing/metabolism"'
Autor:
Ivan Stamenkovic, Miguel Rivera, Angela Volorio, Sowmya Iyer, Liliane C. Broye, Nicolo Riggi, Gaylor Boulay
Publikováno v:
Genes & development, vol. 32, no. 15-16, pp. 1008-1019
Various types of repetitive sequences are dysregulated in cancer. In Ewing sarcoma, the oncogenic fusion protein EWS-FLI1 induces chromatin features typical of active enhancers at GGAA microsatellite repeats, but the function of these sites has not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5970a5a72d1ba8518ad231ed454cdb0
https://pubmed.ncbi.nlm.nih.gov/30068701
https://pubmed.ncbi.nlm.nih.gov/30068701
Autor:
Nicolo Riggi, Anoop P. Patel, Martin J. Aryee, Vishal Thapar, Gaylor Boulay, Aurélie Formey, G. Petur Nielsen, Ivan Stamenkovic, Shawn M. Gillespie, Edward B. Cook, Nikki E. Rossetti, Melissa Gymrek, Mario L. Suvà, Birgit Knoechel, David T. Ting, Francis J. Hornicek, Bradley E. Bernstein, Esther Rheinbay, Vikram Deshpande, Wannaporn E. Boonseng, Ozgur Oksuz, Miguel Rivera
Publikováno v:
Cancer cell, vol. 26, no. 5, pp. 668-681
SummaryThe aberrant transcription factor EWS-FLI1 drives Ewing sarcoma, but its molecular function is not completely understood. We find that EWS-FLI1 reprograms gene regulatory circuits in Ewing sarcoma by directly inducing or repressing enhancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27644e8c251df925d6e8729c03419ab
https://europepmc.org/articles/PMC4492343/
https://europepmc.org/articles/PMC4492343/
