Preparation and Properties of Antitumor Drug Based on Lipid Derivative of Sarcolysin

Autor: V.N. Prozorovsky, A.A. Chistov, Yu.A. Tereshkina, E I Korotkevich, E G Tikhonova, O.M. Ipatova, M.A. Sanzhakov, L V Kostryukova

Publikováno v: Biomedical Chemistry: Research and Methods; Vol. 2 No. 3 (2019); e00098
Biomedical Chemistry: Research and Methods; Том 2 № 3 (2019); e00098
Biomedical Chemistry: Research and Methods

The conditions for the preparation of a drug formulations based on the lipid derivative of sarcolysin embedded in phospholipid nanoparticles have been optimized. The drug is an ultra-thin emulsion with a light transmittance above 80% and a particle s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eb8367376e78d8898e70f8de95b2d7
http://www.bmc-rm.org/index.php/bmcrm/article/view/98

Synthesis and Properties of a Fluorescent-Labeled Triglyceride Derivative of the Antitumor Drug Merphalan

Autor: Boldyrev Ia, Molotkovskiĭ IuG, Pavlova IuB, Grechishnikova

Publikováno v: Russian Journal of Bioorganic Chemistry. 30:71-74

A new fluorescent probe, a 3-perylenoyl derivative of the lipophilized antitumor drug merphalan (sarcolysine), was synthesized. The probe is suitable for studying intracellular traffic and metabolism of merphalan and its derivatives. The perylenoyl f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8933fdbbd790464c4abfa0b0c17575e2
https://doi.org/10.1023/b:rubi.0000015776.60923.96

Acidic coupling and aminolytic TFA cleavage approaches in a new synthesis of an l- m-sarcolysin containing antitumor tripeptide ester

Autor: Imre Weisz, John Roboz, J. George Bekesi

Publikováno v: Tetrahedron Letters. 37:563-566

l -prolyl- l -m-[bis(chloroethyl)amino]-phenylalanyl- l -norvaline ethyl ester hydrochloride, 4 (and its 3 H and 14 C doublylabeled version) was synthesized starting with reacting unprotected l -m-sarcolysin, 1 , with TFA-Pro-Cl in an acidic system t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80a7e62737a875f26b75b883bc3f7fd6
https://doi.org/10.1016/0040-4039(95)02261-9

ChemInform Abstract: New Synthesis of L-m-Sarcolysin and Tritiated Sarcolysin

Autor: J. G. Bekesi, John Roboz, Imre Weisz

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98fc4860e5e96277c15b6198e201242a
https://doi.org/10.1002/chin.199615217

Synthesis and radioprotective properties of sarcolysin-containing peptides

Autor: E. I. Tolstykh, A. G. Shirokova, G. G. Vatulina, E. A. Zhdanova, Victor P. Krasnov

Publikováno v: Pharmaceutical Chemistry Journal. 31:306-308

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62fd5b834a67ad8d1f83b1771f3e0e72
https://doi.org/10.1007/bf02464121