Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sarcolemmas"'
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 11, p e1009179 (2020)
PLoS Genetics, Vol 16, Iss 11, p e1009179 (2020)
Gene therapy approaches for DMD using recombinant adeno-associated viral (rAAV) vectors to deliver miniaturized (or micro) dystrophin genes to striated muscles have shown significant progress. However, concerns remain about the potential for immune r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5e5beaf8e83f1cb59a68636fd0fe39
https://pubmed.ncbi.nlm.nih.gov/33175853
https://pubmed.ncbi.nlm.nih.gov/33175853
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150818 (2016)
PLoS ONE
PLoS ONE
Duchenne muscular dystrophy is a severe and currently incurable progressive neuromuscular condition, caused by mutations in the DMD gene that result in the inability to produce dystrophin. Lack of dystrophin leads to loss of muscle fibres and a reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ffd1f947413c4d3f66fba41631d4831a
https://ora.ox.ac.uk/objects/uuid:925222c2-e1a6-416b-be5d-a3f3202f1e05
https://ora.ox.ac.uk/objects/uuid:925222c2-e1a6-416b-be5d-a3f3202f1e05
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 2, p e0212076 (2019)
PLoS ONE, Vol 14, Iss 2, p e0212076 (2019)
While an ischemic insult poses a lethal danger to myocardial cells, a significant proportion of cardiac myocytes remain viable throughout the ischemic episode and die, paradoxically, only after the blood flow is reinstated. Despite decades of researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8970d63c872942682b93e37f2652f7d4
https://pubmed.ncbi.nlm.nih.gov/30730997
https://pubmed.ncbi.nlm.nih.gov/30730997
Autor:
Valentina, Sardone, Matthew, Ellis, Silvia, Torelli, Lucy, Feng, Darren, Chambers, Deborah, Eastwood, Caroline, Sewry, Rahul, Phadke, Jennifer E, Morgan, Francesco, Muntoni
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194540 (2018)
PLoS ONE
PLoS ONE
Clinical trials using strategies aimed at inducing dystrophin expression in Duchenne muscular dystrophy (DMD) are underway or at advanced planning stage, including splice switching antisense oligonucleotides (AON), drugs to induce read-through of non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::716df25050b878ef30c7832c1a0bc1ee
https://eprints.soton.ac.uk/428175/
https://eprints.soton.ac.uk/428175/
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 8, p e1005714 (2017)
Colman, M A, Pinali, C, Trafford, A W, Zhang, H & Kitmitto, A 2017, ' A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions ', PLoS computational biology, vol. 13, no. 8, pp. e1005714 . https://doi.org/10.1371/journal.pcbi.1005714
PLoS Computational Biology
Colman, M A, Pinali, C, Trafford, A W, Zhang, H & Kitmitto, A 2017, ' A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions ', PLoS computational biology, vol. 13, no. 8, pp. e1005714 . https://doi.org/10.1371/journal.pcbi.1005714
PLoS Computational Biology
Intracellular calcium cycling is a vital component of cardiac excitation-contraction coupling. The key structures responsible for controlling calcium dynamics are the cell membrane (comprising the surface sarcolemma and transverse-tubules), the intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1244fa1db33a7af2b7f6af3854cc0b14
https://doaj.org/article/63f6e3d956cf40498156d469bbba5bba
https://doaj.org/article/63f6e3d956cf40498156d469bbba5bba
Autor:
Gadeberg, Hanne C., Bond, Richard C., Kong, Cherrie H. T., Chanoit, Guillaume P., Ascione, Raimondo, Cannell, Mark B., James, Andrew F.
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156862 (2016)
PLoS ONE
PLoS ONE
Background T-tubules are invaginations of the sarcolemma that play a key role in excitation-contraction coupling in mammalian cardiac myocytes. Although t-tubules were generally considered to be effectively absent in atrial myocytes, recent studies o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9bbf4505115cbf83ba0e1253d9ac7405
http://europepmc.org/articles/PMC4900646?pdf=render
http://europepmc.org/articles/PMC4900646?pdf=render
Autor:
Larissa A. Maltseva, Mary S. Kim, Victor A. Maltsev, Edward G. Lakatta, Dongmei Yang, Syevda Sirenko
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0185222 (2017)
PLoS ONE, Vol 12, Iss 9, p e0185222 (2017)
Uptake and release calcium from the sarcoplasmic reticulum (SR) (dubbed "calcium clock"), in the form of spontaneous, rhythmic, local diastolic calcium releases (LCRs), together with voltage-sensitive ion channels (membrane clock) form a coupled syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366ad2f226b1e6ab4e67416db84e86dd
https://doi.org/10.1371/journal.pone.0185222
https://doi.org/10.1371/journal.pone.0185222
Autor:
Alioua, Abderrahmane
Le but de cette étude était d'élucider les mécanismes biochimiques qui régulent les canaux K$\sp+$ de type (GK$\rm\sb{Ca}),$ impliqués dans le contrôle du tonus des muscles lisses des voies respiratoires (MLVR). Des mesures pharmacologiques on
Externí odkaz:
http://savoirs.usherbrooke.ca/handle/11143/4089