Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sarbani Adhikari"'
Autor:
Marc Bissonnette, Yan Chun Li, Alessandro Fichera, John Hart, Loren Joseph, Vani Konda, Joel Pekow, Abdurahman Khalil, Haider I. Haider, Katherine Meckel, Farhana Sadiq, Sarbani Adhikari, Michelle Fletcher, Fatma Ayaloglu-Butun, Devkumar Mustafi, Urszula Dougherty, Reba Mustafi
Note loss of ADAM17 staining in tumor epithelial cells in ADAM17Î"Î" tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5c868e0a10ea657b45227576fe9fd4
https://doi.org/10.1158/1078-0432.22468682
https://doi.org/10.1158/1078-0432.22468682
Autor:
Marc Bissonnette, Yan Chun Li, Alessandro Fichera, John Hart, Loren Joseph, Vani Konda, Joel Pekow, Abdurahman Khalil, Haider I. Haider, Katherine Meckel, Farhana Sadiq, Sarbani Adhikari, Michelle Fletcher, Fatma Ayaloglu-Butun, Devkumar Mustafi, Urszula Dougherty, Reba Mustafi
Supplemental Figure S3. Marimastat suppresses colonic EGFR signals. Mice received vehicle or marimastat and were fed WD. After 2 wks, colonic proteins measured by WB. A. Alzet pump. B. Protocol. C. EGFR signals. D. Quantitative levels (*p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bddefe5ca0d6e49f1bdf22ad4bafb7
https://doi.org/10.1158/1078-0432.22468694
https://doi.org/10.1158/1078-0432.22468694
Autor:
Marc Bissonnette, Yan Chun Li, Alessandro Fichera, John Hart, Loren Joseph, Vani Konda, Joel Pekow, Abdurahman Khalil, Haider I. Haider, Katherine Meckel, Farhana Sadiq, Sarbani Adhikari, Michelle Fletcher, Fatma Ayaloglu-Butun, Devkumar Mustafi, Urszula Dougherty, Reba Mustafi
Purpose: Epidermal growth factor receptors (EGFR) are required for tumor promotion by Western diet. The metalloprotease, ADAM17 activates EGFR by releasing pro-EGFR ligands. ADAM17 is regulated by G-protein–coupled receptors, including CXCR4. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1cd8cd2ce86c91fd0c00d0e4a593f2
https://doi.org/10.1158/1078-0432.c.6527033.v1
https://doi.org/10.1158/1078-0432.c.6527033.v1
Autor:
Marc Bissonnette, Yan Chun Li, Alessandro Fichera, John Hart, Loren Joseph, Vani Konda, Joel Pekow, Abdurahman Khalil, Haider I. Haider, Katherine Meckel, Farhana Sadiq, Sarbani Adhikari, Michelle Fletcher, Fatma Ayaloglu-Butun, Devkumar Mustafi, Urszula Dougherty, Reba Mustafi
Supplemental Materials and Methods: real time PCR, immunostaining, Western blotting, ADAM17 activity; Supplemental references for supplemental Methods Supplemental Figure Legends; Supplemental Table 1: real time PCR primer sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37eb77bb077083086c72c8b0782aeb82
https://doi.org/10.1158/1078-0432.22468676.v1
https://doi.org/10.1158/1078-0432.22468676.v1
Autor:
Marc Bissonnette, Yan Chun Li, Alessandro Fichera, John Hart, Loren Joseph, Vani Konda, Joel Pekow, Abdurahman Khalil, Haider I. Haider, Katherine Meckel, Farhana Sadiq, Sarbani Adhikari, Michelle Fletcher, Fatma Ayaloglu-Butun, Devkumar Mustafi, Urszula Dougherty, Reba Mustafi
Fig S1. BMS566394 inhibits EGFR signaling in CXCL12 treated HCT116 cells; Fig S2. Schema for CXCL12-CXCR4 transactivation of colon cancer cell EGFR. Shown in the figure are inhibitors or antibodies used in this study: AMD3100 blocks CXCR4; BMS566394
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60489a49f19c2b5803160c2dac63702b
https://doi.org/10.1158/1078-0432.22468697
https://doi.org/10.1158/1078-0432.22468697
Autor:
Marc Bissonnette, Yan Chun Li, Alessandro Fichera, John Hart, Loren Joseph, Vani Konda, Joel Pekow, Abdurahman Khalil, Haider I. Haider, Katherine Meckel, Farhana Sadiq, Sarbani Adhikari, Michelle Fletcher, Fatma Ayaloglu-Butun, Devkumar Mustafi, Urszula Dougherty, Reba Mustafi
A. Left panel Western diet; Right panel Western diet + INCB3619; B. Quantitative Ki67, *p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46514ceccb16da099a9c2041cee593b8
https://doi.org/10.1158/1078-0432.22468691.v1
https://doi.org/10.1158/1078-0432.22468691.v1
Autor:
Wei-Qi Wei, Erin Smithberger, Jennifer A. Pacheco, Gail P. Jarvik, Madeleine Horvath, James G. Linneman, Tanima De, Loukia Parisiadou, Cristina Alarcon, Adam S. Gordon, Juan Avitia, Scott J. Hebbring, Patrick M. A. Sleiman, Chuyu Chen, Hakon Hakonarson, Sarbani Adhikari, Minoli A. Perera, Sara Kwan, Honghong Zhang, Mary Young, John H. Kwon, John B. Harley, Bianca Lec, Frank D. Mentch
Publikováno v:
Pharmacogenet Genomics
OBJECTIVE Primary non-response (PNR) to anti-tumor necrosis factor-α (TNFα) biologics is a serious concern in patients with inflammatory bowel disease (IBD). We aimed to identify the genetic variants associated with PNR. DESIGN Patients were recrui
Autor:
Yinyin Chen, Yan Chun Li, Chunyan Liu, Lei He, Min Zhou, Jie Du, Joel Pekow, David T. Rubin, Sarbani Adhikari
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 316:G774-G784
Previous studies suggest that the renin-angiotensin system (RAS) is a pathogenic factor for colitis. The goal of this study was to elucidate the molecular mechanism whereby angiotensin II (ANG II) promotes colonic inflammation. We found that renin wa
Autor:
Han-Kun Hao, Sarbani Adhikari, Ziwen Liu, Ge Chen, Xiaoping Qian, Yanqun Song, Zhongguang Luo, Yaping Wang, Marc Bissonnette, Xingyu Lu, Wei Zhang, Chuan He, Jie Liu, Wanwei Zheng, Lei You, Jun Zhang, Jianping Shi, Quan Liao, Luchun Hua, Lian-Huan Wei, Shulin Yu, Yuanqiang Dong, Katherine Meckel, Fen Luo, Xin-Xiang Zhang, Ming Cui, Zhang Xu, Wenshuai Li, Peng Wang, Ji Nie, Jun Hong, Yupei Zhao, Taiping Zhang, Guifang Jia, Fang Yuan, Menghua Dai, Diannan Xu
Publikováno v:
Cell Research
DNA modifications such as 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are epigenetic marks known to affect global gene expression in mammals. Given their prevalence in the human genome, close correlation with gene expression and high ch
Autor:
Lei, He, Jie, Du, Yinyin, Chen, Chunyan, Liu, Min, Zhou, Sarbani, Adhikari, David T, Rubin, Joel, Pekow, Yan Chun, Li
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Previous studies suggest that the renin-angiotensin system (RAS) is a pathogenic factor for colitis. The goal of this study was to elucidate the molecular mechanism whereby angiotensin II (ANG II) promotes colonic inflammation. We found that renin wa