Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sarbajeet Nagdas"'
Publikováno v:
Current Oncology, Vol 31, Iss 8, Pp 4305-4317 (2024)
Gastric cancer (GC) represents a major global health challenge as a highly prevalent disease with high mortality whose global incidence and mortality are predicted to worsen over the coming years. To date, our standard of care for advanced gastric ca
Externí odkaz:
https://doaj.org/article/633e4c714ea2473fad94192cc842ccc1
Autor:
Bonnie V Dougherty, Connor J Moore, Kristopher D Rawls, Matthew L Jenior, Bryan Chun, Sarbajeet Nagdas, Jeffrey J Saucerman, Glynis L Kolling, Anders Wallqvist, Jason A Papin
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011919 (2024)
Improvements in the diagnosis and treatment of cancer have revealed long-term side effects of chemotherapeutics, particularly cardiotoxicity. Here, we present paired transcriptomics and metabolomics data characterizing in vitro cardiotoxicity to thre
Externí odkaz:
https://doaj.org/article/f1a37666eac248b987c7dc28c5799574
Autor:
Sarbajeet Nagdas, Jennifer A. Kashatus, Aldo Nascimento, Syed S. Hussain, Riley E. Trainor, Sarah R. Pollock, Sara J. Adair, Alex D. Michaels, Hiromi Sesaki, Edward B. Stelow, Todd W. Bauer, David F. Kashatus
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1845-1859.e5 (2019)
Summary: Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRasG12V promotes mitochondrial fragmentation and tumor growth through Erk
Externí odkaz:
https://doaj.org/article/3897e3f059e04a41b0a0865493500ca3
Supplemental legend from CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer
Autor:
Todd W. Bauer, J. Thomas Parsons, Kodi S. Ravichandran, Craig L. Slingluff, Timothy N. J. Bullock, Jesse B. Persily, Matthew G. Mullen, Sarbajeet Nagdas, Bernadette J. Goudreau, Sho Morioka, Sara J. Adair, Timothy E. Newhook, Alex D. Michaels
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ae90723b16bb6d9c0fa3c8ab5df2c9
https://doi.org/10.1158/1078-0432.22460652.v1
https://doi.org/10.1158/1078-0432.22460652.v1
Autor:
Todd W. Bauer, J. Thomas Parsons, Kodi S. Ravichandran, Craig L. Slingluff, Timothy N. J. Bullock, Jesse B. Persily, Matthew G. Mullen, Sarbajeet Nagdas, Bernadette J. Goudreau, Sho Morioka, Sara J. Adair, Timothy E. Newhook, Alex D. Michaels
Purpose: Patients with pancreatic ductal adenocarcinoma (PDAC) who undergo surgical resection and adjuvant chemotherapy have an expected survival of only 2 years due to disease recurrence, frequently in the liver. We investigated the role of liver ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939bd162b8d708e254072e5725e6b404
https://doi.org/10.1158/1078-0432.c.6524556.v1
https://doi.org/10.1158/1078-0432.c.6524556.v1
Autor:
Walter Varhue, John H. Moore, Edik M. Blais, Sarbajeet Nagdas, Sara J. Adair, John S. McGrath, Armita Salahi, Nathan S. Swami, Carlos Honrado, Todd W. Bauer, Bernadette J. Goudreau, Vahid Farmehini
Publikováno v:
Anal Chim Acta
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer lacking specific biomarkers that can be correlated to disease onset, promotion and progression. To assess whether tumor cell electrophysiology may serve as a marker for PDAC tumorigenici
Autor:
Jeffrey J. Saucerman, Kristopher D. Rawls, Anders Wallqvist, Jason A. Papin, Matthew L. Jenior, Sarbajeet Nagdas, Bonnie V. Dougherty, Glynis L. Kolling, Bryan Chun
Improvements in the diagnosis and treatment of cancer has revealed the long-term side effects of chemotherapeutics, particularly cardiotoxicity. Here, we present paired transcriptomics and metabolomics data characterizing in vitro cardiotoxicity to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e308cd313275108c93d024e88bed406e
https://doi.org/10.1101/2021.10.31.466544
https://doi.org/10.1101/2021.10.31.466544
Autor:
Harun Ozturk, Harun Cingoz, Turan Tufan, Jiekun Yang, Sara J. Adair, Krishna Seshu Tummala, Cem Kuscu, Meric Kinali, Gamze Comertpay, Sarbajeet Nagdas, Bernadette J. Goudreau, Husnu Umit Luleyap, Yagmur Bingul, Timothy B. Ware, William L. Hwang, Ku-lung Hsu, David F. Kashatus, David T. Ting, Navdeep S. Chandel, Nabeel Bardeesy, Todd W. Bauer, Mazhar Adli
Publikováno v:
Developmental cell. 57(11)
Pancreatic ductal adenocarcinoma (PDA) cells reprogram their transcriptional and metabolic programs to survive the nutrient-poor tumor microenvironment. Through in vivo CRISPR screening, we discovered islet-2 (ISL2) as a candidate tumor suppressor th
Autor:
Sara J. Adair, Edward B. Stelow, Sarbajeet Nagdas, Hiromi Sesaki, Todd W. Bauer, Alex D. Michaels, Syed Saad Hussain, Aldo Nascimento, David F. Kashatus, Sarah R. Pollock, Jennifer A. Kashatus, Riley E. Trainor
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1845-1859.e5 (2019)
Cell reports
Cell reports
SUMMARY Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRasG12V promotes mitochondrial fragmentation and tumor growth through Erk
ISL2 is an epigenetically silenced tumor suppressor and regulator of metabolism in pancreatic cancer
Autor:
Todd W. Bauer, Turan Tufan, Mazhar Adli, Ku-Lung Hsu, Nabeel Bardeesy, Sarbajeet Nagdas, Husnu Umit Luleyap, Sara J. Adair, Krishna S. Tummala, Dave F. Kashatus, Cem Kuscu, Bernadette J. Goudreau, Jiekun Yang, Gamze Cömertpay, Harun Cingoz
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Uncovering mechanisms responsible for the heterogeneous clinical features of this disease is an essential step toward developing improved and more specific therapeutic appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0deb28eaa9a043b5308e01cf61f0fb97
https://doi.org/10.1101/2020.05.23.112839
https://doi.org/10.1101/2020.05.23.112839