Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Saravut J. Weroha"'
Autor:
Donglin Ding, Rongbin Zheng, Ye Tian, Rafael Jimenez, Xiaonan Hou, Saravut J. Weroha, Liguo Wang, Lei Shi, Haojie Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here the authors identify retinoblastoma (RB) protein as an intrinsic inhibitor of BRD4 and demonstrate that loss of RB induces BRD4 cistrome changes in the genome and enrichment of GPCR-cAMP signaling pathway, conferring resistance to small molecule
Externí odkaz:
https://doaj.org/article/2d1d3c9ab3354c74b4af0e72ef46ad75
Autor:
Jianong Zhang, Kun Gao, Hongyan Xie, Dejie Wang, Pingzhao Zhang, Ting Wei, Yuqian Yan, Yunqian Pan, Wenbin Ye, Huifen Chen, Qing Shi, Yao Li, Shi-min Zhao, Xiaonan Hou, Saravut J. Weroha, Yuzhuo Wang, Jun Zhang, R. Jeffrey Karnes, Housheng Hansen He, Liguo Wang, Chenji Wang, Haojie Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The molecular mechanism underlying the DNA hypermethylation phenotype observed in the SPOP-mutant prostate cancers is unclear. Here, the authors show that mutant SPOP induces global aberrant DNA methylation patterns through GLP/G9a and renders prosta
Externí odkaz:
https://doaj.org/article/db75dbabc63044e4b2c4d83423549287
Autor:
Dongyan Liu, Xiaonan Hou, Wangyu Wu, Valentina Zafagnin, Yunjian Li, Cristina Correia, Zhiyang Zhao, Chenggang Zhao, Zhirong Liu, Tao Zhang, Zhiyou Fang, Hongzhi Wang, Chao Xu, Saravut J. Weroha, Scott H. Kaufmann, Haiming Dai
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-13 (2021)
Abstract We previously found that preformed complexes of BAK with antiapoptotic BCL2 proteins predict BH3 mimetic sensitivities in lymphohematopoietic cells. These complexes have not previously been examined in solid tumors or in the context of conve
Externí odkaz:
https://doaj.org/article/2f80da113f4649caa529123252945666
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Next-generation sequencing provides comprehensive information about individuals’ genetic makeup and is commonplace in oncology clinical practice. However, the utility of genetic information in the clinical decision-making proces
Externí odkaz:
https://doaj.org/article/728400bef2264997a8eec2e8d92e8411
Autor:
Faye R. Harris, Piyan Zhang, Lin Yang, Xiaonan Hou, Konstantinos Leventakos, Saravut J. Weroha, George Vasmatzis, Irina V. Kovtun
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 132-152 (2019)
Ovarian cancer is the most lethal gynecologic malignancy. About 75% of ovarian cancer patients relapse and/or develop chemo‐resistant disease after initial response to standard‐of‐care treatment with platinum‐based therapies. HER2 amplificati
Externí odkaz:
https://doaj.org/article/96517e9183104d659c8a41dd206adf79
Autor:
Dongyan Liu, Xiaonan Hou, Wangyu Wu, Valentina Zafagnin, Yunjian Li, Cristina Correia, Zhiyang Zhao, Chenggang Zhao, Zhirong Liu, Tao Zhang, Zhiyou Fang, Hongzhi Wang, Chao Xu, Saravut J. Weroha, Scott H. Kaufmann, Haiming Dai
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/c3e0f238595f4dd4a825a76ef9c63ede
Autor:
Louis Y El Khoury, Wan Hsin Lin, James B Smadbeck, Michael T Barrett, Dorsay Sadeghian, Alexa F McCune, Giannoula Karagouga, John C Cheville, Faye R Harris, Lindsey M Kinsella, Ryan W Feathers, Janet L Schafer Klein, Marina RS Walther-Antonio, Sarah H Johnson, Alan R Penheiter, Giuseppe Cucinella, Gabriella Schivardi, Aditya Bhagwate, Mitesh J Borad, Aaron S Mansfield, Stephen J Murphy, Andrea Mariani, George Vasmatzis, Panos Z Anastasiadis, Saravut J Weroha, Alyssa M Larish
Publikováno v:
Epigenomics. 15:283-292
This work examines differences in chromatin accessibility, methylation, and response to DNA hypomethylating agents between mismatch repair-deficient and non-mismatch repair-deficient endometrial cancer. Next-generation sequencing of a stage 1B, grade
Autor:
Yunqian Pan, Hongyan Xie, Haojie Huang, Chenji Wang, Ting Wei, Saravut J. Weroha, Yuzhuo Wang, Jun Zhang, R. Jeffrey Karnes, Dejie Wang, Wenbin Ye, Housheng Hansen He, Liguo Wang, Qing Shi, Shimin Zhao, Yuqian Yan, Huifen Chen, Xiaonan Hou, Jianong Zhang, Kun Gao, Pingzhao Zhang, Yao Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Mutations in SPOP E3 ligase gene are reportedly associated with genome-wide DNA hypermethylation in prostate cancer (PCa) although the underlying mechanisms remain elusive. Here, we demonstrate that SPOP binds and promotes polyubiquitination and degr
Autor:
Esther Rodman, Michael Emch, Elizabeth Bruinsma, Xiaonan Hou, Scott Kaufmann, Saravut J. Weroha, John Hawse
Publikováno v:
Cancer Research. 83:4862-4862
Ovarian cancer is the 7th most common cancer in women and the most fatal of all female reproductive cancers, with 5-year overall survival of 10-30%. Despite initial responses to first line platinum- and paclitaxel-based chemotherapies, >70% of ovaria
Autor:
Cristina Correia, Dongyan Liu, Wangyu Wu, Chao Xu, Zhirong Liu, Tao Zhang, Zhiyou Fang, Yunjian Li, Chenggang Zhao, Zhiyang Zhao, Valentina Zafagnin, Xiaonan Hou, Haiming Dai, Saravut J. Weroha, Scott H. Kaufmann, Hongzhi Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-1 (2021)