Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Saravanan Thiyagarajan"'
Autor:
Manjunath Krishnappa, Divyesh Mandavia, Minish Jain, Mukesh S, Ankit Patel, Anshul Agarwal, Sanjeev Giri, Nirbhay Kumar Tiwari, Saravanan Thiyagarajan, Mamon Dey, Gutta Padmanabha Naidu, Murali Ramachandra, Akhil Kumar
Publikováno v:
HemaSphere, Vol 7, p e183727f (2023)
Externí odkaz:
https://doaj.org/article/6ad1547013ca44a2b06e4f4eb555b075
Autor:
Michelle Przedborski, Munisha Smalley, Saravanan Thiyagarajan, Aaron Goldman, Mohammad Kohandel
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Michelle Przedborski et al. report an integrative systems biology and machine learning method for predicting cancer patient responses to immunotherapy treatment. Using their method, they identify several new drug combinations that could potentially i
Externí odkaz:
https://doaj.org/article/44e3f66755784e83bdb6e51e9bad3437
Autor:
Munisha Smalley, Michelle Przedborski, Saravanan Thiyagarajan, Moriah Pellowe, Amit Verma, Nilesh Brijwani, Debika Datta, Misti Jain, Basavaraja U. Shanthappa, Vidushi Kapoor, Kodaganur S. Gopinath, D.C. Doval, K.S. Sabitha, Gaspar Taroncher-Oldenburg, Biswanath Majumder, Pradip Majumder, Mohammad Kohandel, Aaron Goldman
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101229- (2020)
Summary: Ex vivo human tumor models have emerged as promising, yet complex tools to study cancer immunotherapy response dynamics. Here, we present a strategy that integrates empirical data from an ex vivo human system with computational models to int
Externí odkaz:
https://doaj.org/article/575a67d6a91847c882f2028f31c0496f
Autor:
Niraj Babu, Sonali Mohan, Vishalakshi Nanjappa, Sandip Chavan, Jayshree Advani, Aafaque Ahmed Khan, Santosh Renuse, Aneesha Radhakrishnan, T.S. Keshava Prasad, Rekha V. Kumar, Jay Gopal Ray, Manjusha Biswas, Saravanan Thiyagarajan, Joseph A. Califano, David Sidransky, Harsha Gowda, Aditi Chatterjee
Publikováno v:
Data in Brief, Vol 19, Iss , Pp 1124-1130 (2018)
Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in India. Despite improvements in treatment strategy, the survival rates of HNSCC patients remain poor. Thus, it is necessary to identify biomarkers that can be used for
Externí odkaz:
https://doaj.org/article/4db0e8d158e94c5b9597842b8f8929af
Autor:
Nilesh Brijwani, Misti Jain, Muthu Dhandapani, Farrah Zahed, Pragnashree Mukhopadhyay, Manjusha Biswas, Deepak Khatri, Vinod D. Radhakrishna, Biswanath Majumder, Padhma Radhakrishnan, Saravanan Thiyagarajan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract KRAS mutation status can distinguish between metastatic colorectal carcinoma (mCRC) patients who may benefit from therapies that target the epidermal growth factor receptor (EGFR), such as cetuximab. However, patients whose tumors harbor mut
Externí odkaz:
https://doaj.org/article/b5b8991e965f494584339194df603f2f
Autor:
Phuoc T Tran, Emelyn H Shroff, Timothy F Burns, Saravanan Thiyagarajan, Sandhya T Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J Adam, Silvestre Vicent, Carsten H Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S Gambhir, Charles M Rudin, Dean W Felsher
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002650 (2012)
KRAS mutant lung cancers are generally refractory to chemotherapy as well targeted agents. To date, the identification of drugs to therapeutically inhibit K-RAS have been unsuccessful, suggesting that other approaches are required. We demonstrate in
Externí odkaz:
https://doaj.org/article/888bf29c10e84b71a81ce396c6901816
Autor:
Jothi Saravanan Thiyagarajan
Publikováno v:
The 1st International Electronic Conference on Applied Sciences.
Autor:
Phuoc T. Tran, Steven S. An, Venu Raman, Russell K. Hales, Joseph M. Herman, Charles M. Rudin, Christine H. Chung, Timothy F. Burns, Shyam Biswal, Elana Fertig, Jessica Cades, Tarek Salih, Jinfang Ma, Farhad Vesuna, Aaron T. Wild, Nishant Gandhi, Ruoqi Wang, Khaled Aziz, Yoshinori Kato, Saravanan Thiyagarajan, Russell D. Williams, Sivarajan T. Chettiar, Rajendra P. Gajula
PDF file - 1004K, S1. The Twist box domain is required for full Twist1 transcriptional activity. S2. Quantification of immunofluorescence from isogenic prostate cancer cell lines stably expressing Twist1 and Twist1-F191G. S3. The Twist box domain is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0f303bae5dc7eb4eb4d671c2b9dd94
https://doi.org/10.1158/1541-7786.22510158
https://doi.org/10.1158/1541-7786.22510158
Autor:
Charles M. Rudin, Phuoc T. Tran, Yoon-Jae Cho, Khaled Aziz, Sarah N.H. Chatley, Saravanan Thiyagarajan, Rajendra P. Gajula, Sara C. Murphy, Irina Dobromilskaya, Timothy F. Burns
Supplementary Data PDF file - 114K, Supplemental Table 1 Mutational status of cell lines studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f4018b3b91f80786ced750d55fcb99
https://doi.org/10.1158/1541-7786.22517365
https://doi.org/10.1158/1541-7786.22517365
Autor:
Charles M. Rudin, Phuoc T. Tran, Yoon-Jae Cho, Khaled Aziz, Sarah N.H. Chatley, Saravanan Thiyagarajan, Rajendra P. Gajula, Sara C. Murphy, Irina Dobromilskaya, Timothy F. Burns
Supplementary Figures PDF file - 3634K, S1 TWIST1 specific shRNAs suppress TWIST1 transcript and protein levels. S2 Mouse Twist1 can rescue the anti-proliferative effects of knockdown of human TWIST1 in A549 cells. S3 Growth inhibition by silencing T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7526f69acb9b527677e5290ef5dc1a
https://doi.org/10.1158/1541-7786.22517362.v1
https://doi.org/10.1158/1541-7786.22517362.v1