Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Saravanan S, Karuppagounder"'
Autor:
Amit Kumar, Manisha Vaish, Saravanan S Karuppagounder, Irina Gazaryan, John W Cave, Anatoly A Starkov, Elizabeth T Anderson, Sheng Zhang, John T Pinto, Austin M Rountree, Wang Wang, Ian R Sweet, Rajiv R Ratan
Publikováno v:
eLife, Vol 10 (2021)
Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1α stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen into the second m
Externí odkaz:
https://doaj.org/article/5101dfdcd63d48c8a22c4fac2e9e0afc
Autor:
Johannes Boltze, Jaroslaw A. Aronowski, Jerome Badaut, Marion S. Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R. Dave, Nadine Didwischus, Rick M. Dijkhuizen, Thorsten R. Doeppner, Jens P. Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A. Gregson, Edith Hamel, Daniel F. Hanley, Wolfgang Härtig, Friedhelm C. Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S. Karuppagounder, Richard F. Keep, Inga K. Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A. S. Metz, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M. Planas, Nikolaus Plesnila, Ami P. Raval, Maria A. Rueger, Lauren H. Sansing, Farida Sohrabji, Charlotte J. Stagg, R. Anne Stetler, Ann M. Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U. Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potenti
Externí odkaz:
https://doaj.org/article/b0240d81d38449e096924c6f8ac55632
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105145- (2021)
A major thrust of our laboratory has been to identify how physiological stress is transduced into transcriptional responses that feed back to overcome the inciting stress or its consequences, thereby fostering survival and repair. To this end, we hav
Externí odkaz:
https://doaj.org/article/061199407e804797a4505ad711ddd33c
Autor:
George Z Wei, Sujata Saraswat Ohri, Nicolas K Khattar, Adam W Listerman, Catherine H Doyle, Kariena R Andres, Saravanan S Karuppagounder, Rajiv R Ratan, Scott R Whittemore, Michal Hetman
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249591 (2021)
Traumatic spinal cord injury (SCI) is a devastating neurological condition that involves both primary and secondary tissue loss. Various cytotoxic events including hypoxia, hemorrhage and blood lysis, bioenergetic failure, oxidative stress, endoplasm
Externí odkaz:
https://doaj.org/article/afcf059cd1dc42a1bcc67fbc7242ecef
Autor:
Pascaline Aimé, Saravanan S. Karuppagounder, Apeksha Rao, Yingxin Chen, Robert E. Burke, Rajiv R. Ratan, Lloyd A. Greene
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104725- (2020)
Identifying disease-causing pathways and drugs that target them in Parkinson's disease (PD) has remained challenging. We uncovered a PD-relevant pathway in which the stress-regulated heterodimeric transcription complex CHOP/ATF4 induces the neuron pr
Externí odkaz:
https://doaj.org/article/e4d8cb29d6394909a61a7bb6794439bf
Autor:
Brian T. David, Jessica J. Curtin, Jennifer L. Brown, Kerri Scorpio, Veena Kandaswamy, David J. C. Coutts, Ana Vivinetto, Paola Bianchimano, Saravanan S. Karuppagounder, Mariajose Metcalfe, John W. Cave, Caitlin E. Hill
Publikováno v:
GliaREFERENCES.
Hypoxic preconditioning is protective in multiple models of injury and disease, but whether it is beneficial for cells transplanted into sites of spinal cord injury (SCI) is largely unexplored. In this study, we analyzed whether hypoxia-related preco
Autor:
Marietta Zille, Juan A. Oses-Prieto, Sara R. Savage, Saravanan S. Karuppagounder, Yingxin Chen, Amit Kumar, John H. Morris, Karl A. Scheidt, Alma L. Burlingame, Rajiv R. Ratan
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 42, iss 10
J Neurosci
J Neurosci
Ferroptosis is a caspase-independent, iron-dependent form of regulated necrosis extant in traumatic brain injury, Huntington disease, and hemorrhagic stroke. It can be activated by cystine deprivation leading to glutathione depletion, the insufficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c4987a4d1b76158a4974368bc3e3f3
https://escholarship.org/uc/item/7904g2wz
https://escholarship.org/uc/item/7904g2wz
Autor:
Sama F Sleiman, Jeffrey Henry, Rami Al-Haddad, Lauretta El Hayek, Edwina Abou Haidar, Thomas Stringer, Devyani Ulja, Saravanan S Karuppagounder, Edward B Holson, Rajiv R Ratan, Ipe Ninan, Moses V Chao
Publikováno v:
eLife, Vol 5 (2016)
Exercise induces beneficial responses in the brain, which is accompanied by an increase in BDNF, a trophic factor associated with cognitive improvement and the alleviation of depression and anxiety. However, the exact mechanisms whereby physical exer
Externí odkaz:
https://doaj.org/article/a52946b4a9ff4c8aaad007234517c46e
Autor:
Nandini Kundu, Amit Kumar, Carlo Corona, Yingxin Chen, Sonia Seth, Saravanan S. Karuppagounder, Rajiv R. Ratan
Publikováno v:
Brain communications. 4(3)
Converging lines of inquiry have highlighted the importance of the Type I antiviral response not only in defending against viruses but also in preconditioning the brain against ischaemic stroke. Despite this understanding, treatments that foster brai
Autor:
Rajiv R. Ratan, Manisha Vaish, Ian R. Sweet, Anatoly A. Starkov, Amit Kumar, Sheng Zhang, Irina G. Gazaryan, John T. Pinto, Saravanan S. Karuppagounder, John W. Cave, Elizabeth T Anderson, Wang Wang, Austin M. Rountree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fe54fe978547fbdd344fcc2e8e5f3a
https://doi.org/10.7554/elife.72873.sa2
https://doi.org/10.7554/elife.72873.sa2