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Optimization of Nicotinamides as Potent and Selective IRAK4 Inhibitors with Efficacy in a Murine Model of Psoriasis.

Autor: Nair S; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Kumar SR; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Paidi VR; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Sistla R; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Kantheti D; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Polimera SR; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Thangavel S; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Mukherjee AJ; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Das M; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Bhide RS; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Pitts WJ; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Murugesan N; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Dudhgoankar S; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Nagar J; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Subramani S; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Mazumder D; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Carman JA; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Holloway DA; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Li X; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Fereshteh MP; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Ruepp S; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Palanisamy K; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Mariappan TT; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Maddi S; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Saxena A; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Elzinga P; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Chimalakonda A; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Ruan Q; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Ghosh K; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Bose S; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Sack J; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Yan C; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Kiefer SE; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Xie D; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Newitt JA; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Saravanakumar SP; Biocon Bristol Myers Squibb Research Center, Bangalore 560099, India., Rampulla RA; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Barrish JC; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Carter PH; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States., Hynes J Jr; Research & Development, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Jun 10; Vol. 11 (7), pp. 1402-1409. Date of Electronic Publication: 2020 Jun 10 (Print Publication: 2020).