Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Saravana Kanagavelu"'
Autor:
James M Termini, Sachin Gupta, Francesca N Raffa, Elizabeth Guirado, Margaret A Fischl, Liguo Niu, Saravana Kanagavelu, Geoffrey W Stone
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184915 (2017)
Dendritic cells (DC) are a promising cell type for cancer vaccines due to their high immunostimulatory capacity. However, improper maturation of DC prior to treatment may account for the limited efficacy of DC vaccine clinical trials. Latent Membrane
Externí odkaz:
https://doaj.org/article/448aad0fe5154a0d839799023da9a83b
Autor:
Saravana Kanagavelu, James M Termini, Sachin Gupta, Francesca N Raffa, Katherine A Fuller, Yaelis Rivas, Sakhi Philip, Richard S Kornbluth, Geoffrey W Stone
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90100 (2014)
Adenoviral vectored vaccines have shown considerable promise but could be improved by molecular adjuvants. Ligands in the TNF superfamily (TNFSF) are potential adjuvants for adenoviral vector (Ad5) vaccines based on their central role in adaptive imm
Externí odkaz:
https://doaj.org/article/aefbed439bb74e47bfe996434dee1576
Autor:
Justin Nice, Alanna Sedgwick, Chenxu Guo, Shang Jui Tsai, Arjang Salehi, Saravana Kanagavelu, Stephen Jay Gould, Nadia A. Atai, Mafalda Cacciottolo
Publikováno v:
The Journal of Biological Chemistry
Functional delivery of mRNA has high clinical potential. Previous studies established that mRNAs can be delivered to cells in vitro and in vivo via RNA-loaded lipid nanoparticles (LNPs). Here we describe an alternative approach using exosomes, the on
Autor:
Sanjana Shetty, Stephen Jay Gould, Saravana Kanagavelu, Connie Landaverde, Chenxu Guo, Alanna Sedgwick, Shang Jui Tsai, Nadia A. Atai, Justin Nice
Background In less than a year from its zoonotic entry into the human population, SARS-CoV-2 has infected more than 45 million people, caused 1.2 million deaths, and induced widespread societal disruption. Leading SARS-CoV-2 vaccine candidates immuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f824ebc55bc4afed96f62cdaf8c2c55a
https://doi.org/10.1101/2020.11.06.371419
https://doi.org/10.1101/2020.11.06.371419
Autor:
Kurt Schesser, Saravana Kanagavelu, Reldy Riveron, James M. Termini, Claudia Flores, Moshe Arditi, Masayuki Fukata, Jose Ruiz, Laura Romero
Publikováno v:
Infection and Immunity. 83:4404-4415
Induction of adaptive immunity leads to the establishment of immunological memory; however, how innate immunity regulates memory T cell function remains obscure. Here we show a previously undefined mechanism in which innate and adaptive immunity are
Autor:
Justin Boucher, Sakhi Abraham, Wasif N. Khan, David C. Montefiori, Saravana Kanagavelu, Celia C LeBranche, Geoffrey W. Stone, Sachin Gupta, James M. Termini, Emily S. Clark
Publikováno v:
Journal of Virology. 89:4158-4169
Broadly neutralizing antibodies (bNAbs) specific for conserved epitopes on the HIV-1 envelope (Env) are believed to be essential for protection against multiple HIV-1 clades. However, vaccines capable of stimulating the production of bNAbs remain a m
Autor:
Jose Ruiz, Pedro Salas, Stephan R. Targan, John P. Sotolongo, Jinhee Hyun, Ana Laura Alonso, Reldy Riveron, Claudia Flores, Saravana Kanagavelu, Masayuki Fukata, Sally Chun, Gaurav Singh, Kristina D. Chung, Laura Romero, Armine Manukyan
Publikováno v:
Journal of Innate Immunity. 7:87-101
In the intestine, interaction between epithelial cells and macrophages (MΦs) create a unique immunoregulatory microenvironment necessary to maintain local immune and tissue homeostasis. Human intestinal epithelial cells (IECs) have been shown to exp
Autor:
Saravana, Kanagavelu, Claudia, Flores, Shinichiro, Hagiwara, Jose, Ruiz, Jinhee, Hyun, Ei E, Cho, Frank, Sun, Laura, Romero, David Q, Shih, Masayuki, Fukata
Publikováno v:
Journal of clinicalcellular immunology. 7(5)
Establishing an effective humoral immunity is an important host defense mechanism in intestinal mucosa. T follicular helper (Tfh) cells are a spectrum of CXCR5 expressing T helper cells that induce antigen-specific B cell differentiation. Because the
Publikováno v:
Microbes and Infection
Both anti-viral and anti-bacterial host defense mechanisms involve TRIF signaling. TRIF provides early clearance of pathogens and coordination of a local inflammatory ensemble through an interferon cascade, while it may trigger organ damage. The mult
Autor:
Shinichiro Hagiwara, Ei E. Cho, Laura Romero, Claudia Flores, Frank Sun, Jose Ruiz, Jinhee Hyun, Masayuki Fukata, Saravana Kanagavelu, David Q. Shih
Publikováno v:
Journal of Clinical & Cellular Immunology. 7
Objective: Establishing an effective humoral immunity is an important host defense mechanism in intestinal mucosa. T follicular helper (Tfh) cells are a spectrum of CXCR5 expressing T helper cells that induce antigenspecific B cell differentiation. B