Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Saravana G. Baskaran"'
Autor:
David M. Walter, Amy C. Gladstein, Katherine R. Doerig, Ramakrishnan Natesan, Saravana G. Baskaran, A. Andrea Gudiel, Keren M. Adler, Jonuelle O. Acosta, Douglas C. Wallace, Irfan A. Asangani, David M. Feldser
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
SETD2 inactivation leads to heightened mTORC1 signaling, oxidative metabolism and protein synthesis in KRAS-driven mouse models of lung adenocarcinoma, contributing to the understanding of how SETD2 deficiency drives early and widespread tumor growth
Externí odkaz:
https://doaj.org/article/c2c79fc965134987aff07bf0f609c365
Autor:
David M. Walter, Amy C. Gladstein, Katherine R. Doerig, Ramakrishnan Natesan, Saravana G. Baskaran, A. Andrea Gudiel, Keren M. Adler, Jonuelle O. Acosta, Douglas C. Wallace, Irfan A. Asangani, David M. Feldser
SETD2 is a tumor suppressor that is frequently inactivated in several cancer types. The mechanisms through which SETD2 inactivation promotes cancer are unclear, and whether targetable vulnerabilities exist in these tumors is unknown. Here we identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a47993f898eae9c514211d3a1bbcb6
https://doi.org/10.1101/2022.10.06.511146
https://doi.org/10.1101/2022.10.06.511146
Publikováno v:
Journal of Chemical Information and Modeling. 61:1427-1443
The Dockeye software is designed to complement automated docking protocols by allowing the user's chemical know-how and experience of what makes for good protein-ligand binding, knowledge that is not easily encoded into automated algorithms, to guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524a0734f7b1f8990c9d0422f8d5a683
https://doi.org/10.1021/acs.jcim.0c01485
https://doi.org/10.1021/acs.jcim.0c01485