Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Sarath Vijayakumar"'
Autor:
Vasiliki Georgia Paplou, Nick M. A. Schubert, Marcel van Tuinen, Sarath Vijayakumar, Sonja J. Pyott
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1429 (2023)
Age-related loss of vestibular function and hearing are common disorders that arise from the loss of function of the inner ear and significantly decrease quality of life. The underlying pathophysiological mechanisms are poorly understood and difficul
Externí odkaz:
https://doaj.org/article/82b0ab3b2200478bb226f42d917a71f7
Autor:
Kazuya Ono, James Keller, Omar López Ramírez, Antonia González Garrido, Omid A. Zobeiri, Hui Ho Vanessa Chang, Sarath Vijayakumar, Andrianna Ayiotis, Gregg Duester, Charles C. Della Santina, Sherri M. Jones, Kathleen E. Cullen, Ruth Anne Eatock, Doris K. Wu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The coding of sensory inputs at the level of vestibular sensory organs is not well understood. In this study, the authors demonstrate that the formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated d
Externí odkaz:
https://doaj.org/article/084c5655bae6444e9673319881b6fdc4
Autor:
Sherri M. Jones, Sarath Vijayakumar, Samantha A. Dow, Joseph C. Holt, Paivi M. Jordan, Anne E. Luebke
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Calcitonin gene-related peptide (CGRP) is a neuroactive peptide that is thought to play a role at efferent synapses in hair cell organs including the cochlea, lateral line, and semicircular canal. The deletion of CGRP in transgenic mice is associated
Externí odkaz:
https://doaj.org/article/93386142e14348538c2815ba79a7a79d
Autor:
Michelle W Antoine, Xiaoxia Zhu, Marianne Dieterich, Thomas Brandt, Sarath Vijayakumar, Nicholas McKeehan, Joseph C Arezzo, R Suzanne Zukin, David A Borkholder, Sherri M Jones, Robert D Frisina, Jean M Hébert
Publikováno v:
PLoS Biology, Vol 16, Iss 3, p e2002988 (2018)
How asymmetries in motor behavior become established normally or atypically in mammals remains unclear. An established model for motor asymmetry that is conserved across mammals can be obtained by experimentally inducing asymmetric striatal dopamine
Externí odkaz:
https://doaj.org/article/585efff9782148cebaf22e2e325004ed
Autor:
Pezhman Salehi, Marisa Zallocchi, Sarath Vijayakumar, Madeleine Urbanek, Kimberlee P. Giffen, Yuju Li, Santanu Hati, Jian Zuo
Acquired hearing loss is a major health problem that affects 5-10% of the world population. However, there are no FDA-approved drugs for the treatment or prevention of hearing loss. Employing the Connectivity Map (CMap) that contains >54,000 compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9416035a483b3b155f7f0b867aaab5fe
https://doi.org/10.1101/2022.01.26.477836
https://doi.org/10.1101/2022.01.26.477836
Autor:
Lisa L. Cunningham, Inna A. Belyantseva, Meghan C. Drummond, Thomas B. Friedman, Sherri M. Jones, Tracy S. Fitzgerald, Wade W. Chien, Andrew J. Griffith, Kevin Isgrig, Sarath Vijayakumar, Jack W. Shteamer
Publikováno v:
Mol Ther
Dizziness and hearing loss are among the most common disabilities. Many forms of hereditary balance and hearing disorders are caused by abnormal development of stereocilia, mechanosensory organelles on the apical surface of hair cells in the inner ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82160084769f5769cd5ea9ebcc844eed
https://europepmc.org/articles/PMC8822160/
https://europepmc.org/articles/PMC8822160/
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
The cupula is a gelatinous membrane overlying the crista ampullaris of the semicircular canal, important for sensing rotation of the head and critical for normal balance. Recently the zona pellucida like domain containing 1 protein (ZPLD1, also known
Autor:
Shikha Tarang, Kay Uwe Wagner, Michael D. Weston, Umesh Pyakurel, Sonia M. Rocha-Sanchez, Timothy A. Jones, Sarath Vijayakumar
Publikováno v:
Hear Res
The retinoblastoma family of pocket proteins (pRBs), composed of Rb1, p107, and p130 are negative regulators of cell-cycle progression. The deletion of any individual pRB in the auditory system triggers hair cells' (HCs) and supporting cells' (SCs) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8406ad7dcaae314b1ba522f0b2051164
https://europepmc.org/articles/PMC7204889/
https://europepmc.org/articles/PMC7204889/
Autor:
Doris K. Wu, Gregg Duester, Kathleen E. Cullen, Kazuya Ono, Omid A. Zobeiri, Omar López Ramírez, James M. Keller, Andrianna I. Ayiotis, Sarath Vijayakumar, Charles C. Della Santina, Sherri M. Jones, Antonia González Garrido, Ruth Anne Eatock, Hui Ho Vanessa Chang
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Each vestibular sensory epithelium in the inner ear is divided morphologically and physiologically into two zones, called the striola and extrastriola in otolith organ maculae, and the central and peripheral zones in semicircular canal cristae. We fo
Autor:
Yan Zhang, Liping Yang, Yunxia Wang Lundberg, Sarath Vijayakumar, Yinfang Xu, Sherri M. Jones
Publikováno v:
Journal of the Association for Research in Otolaryngology. 19:353-362
Otoconia-related vertigo and balance deficits, particularly benign paroxysmal positional vertigo (BPPV), are common. Our recent studies in humans show that, while BPPV prevalence greatly increases with age in both genders, peri-menopausal women are e