Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sarath Meduru"'
Autor:
Anjali M. Prabhat, M. Lakshmi Kuppusamy, Shan K. Naidu, Sarath Meduru, Praneeth T. Reddy, Abishai Dominic, Mahmood Khan, Brian K. Rivera, Periannan Kuppusamy
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
Myocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If left untreated, MI will lead to progressive loss of viable cardiomyocytes, deterioration of ca
Externí odkaz:
https://doaj.org/article/03e7c0169b1c4e198268c6691330f82e
Autor:
Kazuaki Taguchi, Mahmoud M. Mostafa, M. Lakshmi Kuppusamy, Sarath Meduru, Periannan Kuppusamy, Mahmood Khan, Fatemat Hassan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:62-71
Adult stem cells have shown great promise toward repairing infarcted heart and restoring cardiac function. Mesenchymal stem cells (MSCs), because of their inherent multipotent nature and their ability to secrete a multitude of growth factors and cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfaf0a4851887f0c687ec5730261ee07
https://doi.org/10.1124/jpet.112.196915
https://doi.org/10.1124/jpet.112.196915
Hyperbaric oxygenation enhances transplanted cell graft and functional recovery in the infarct heart
Autor:
Brian K. Rivera, Periannan Kuppusamy, Robert L. Hamlin, M. Lakshmi Kuppusamy, Sheik Wisel, Sarath Meduru, Iyyapu Krishna Mohan, Aditi C. Kulkarni, Mahmood Khan
Publikováno v:
Journal of Molecular and Cellular Cardiology. 47:275-287
A major limitation to the application of stem-cell therapy to repair ischemic heart damage is the low survival of transplanted cells in the heart, possibly due to poor oxygenation. We hypothesized that hyperbaric oxygenation (HBO) can be used as an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2536a24e9cde6cfe2ba9d61d468aa86
https://doi.org/10.1016/j.yjmcc.2009.04.005
https://doi.org/10.1016/j.yjmcc.2009.04.005
Autor:
Devashish H. Desai, Anjaiah Katta, Sarath Meduru, Eric R. Blough, Miaozong Wu, Sunil K. Karkala, Kevin M. Rice
Publikováno v:
Muscle & Nerve. 39:503-511
Increased phosphorylation of the 70-kDa ribosomal S6 kinase (p70S6k) signaling is strongly correlated with the degree of muscle adaptation following exercise. Herein we compare the phosphorylation of p70S6k, Akt, and mammalian target of rapamycin (mT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e75955fbc0c978681104547e5c78394
https://doi.org/10.1002/mus.21255
https://doi.org/10.1002/mus.21255
Autor:
Mahmood Khan, Karuppaiyah Selvendiran, Chittoor B. Sai-Sudhakar, Lucas Citro, Yazhini Ravi, Brian K. Rivera, Shan Naidu, Periannan Kuppusamy, Sarath Meduru
Pulmonary hypertension (PH) is a disorder of lung vasculature characterized by arterial narrowing. Phosphatase-and-tensin homolog on chromosome 10 (PTEN), associated in the progression of multiple cancers, is implicated in arterial remodeling. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5a1ca7a38afeb039bfbee7807c3d29
https://europepmc.org/articles/PMC4596526/
https://europepmc.org/articles/PMC4596526/
Autor:
Sarath Meduru, Tamás Kálai, Chittoor B. Sai-Sudhakar, Shan Naidu, Periannan Kuppusamy, Yazhini Ravi, Balázs Bognár, Kálmán Hideg, Mahmood Khan, Karuppaiyah Selvendiran, Lucas Citro
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 61(3)
Pulmonary hypertension (PH) that occurs after left-heart failure (LHF), classified as Group 2 PH, involves progressive pulmonary vascular remodeling induced by smooth muscle cell (SMC) proliferation. However, mechanisms involved in the activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfa948b98da41f281869b98c639a739
https://pubmed.ncbi.nlm.nih.gov/23339168
https://pubmed.ncbi.nlm.nih.gov/23339168
Autor:
Kevin M, Rice, Sarath, Meduru, Sunil K, Kakarla, Anjaiah, Katta, Sriram P, Mupparaju, Brent, Kidd, Lynne J, Goebel, Eric R, Blough
Publikováno v:
Annals of clinical and laboratory science. 42(2)
Previous reports have demonstrated that increased levels of reactive oxygen species (ROS) and alterations in cell signaling characterize aging in the Fischer 344 X Brown Norway (FBN) rat aorta. Other work has suggested that increases in ROS may be re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d3e71b7014aadafd3791a69fdb7c9d8
https://pubmed.ncbi.nlm.nih.gov/22585611
https://pubmed.ncbi.nlm.nih.gov/22585611
Autor:
Kálmán Hideg, Mahmood Khan, Shan Naidu, Karuppaiyah Selvendiran, Periannan Kuppusamy, M. Lakshmi Kuppusamy, Alex Dayton, Tamás Kálai, Sarath Meduru
Doxorubicin (DOX) is a drug commonly used for the treatment of cancer. The development of resistance to DOX is common, and high cumulative doses cause potentially lethal cardiac side effects. HO-3867 (3,5-bis(4-fluorobenzylidene)-1-[(2,2,5,5-tetramet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d5511d12a054b7ce5f52016fdee1c3
https://europepmc.org/articles/PMC3199994/
https://europepmc.org/articles/PMC3199994/
Autor:
Lucas Citro, Sarath Meduru, Robert L. Hamlin, Periannan Kuppusamy, Mahmood Khan, Rajan Gogna, Mahmoud M. Mostafa, Muthulakshmi L. Kuppusamy, Muzzammil Sayyid, Esha Madan
Publikováno v:
Cardiovascular research. 93(1)
Aims Myocardial infarction (MI) is associated with irreversible loss of viable cardiomyocytes. Cell therapy is a potential option to replace the lost cardiomyocytes and restore cardiac function. However, cell therapy is faced with a number of challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb3212fb9507c1c4338c81be44f0e78
https://pubmed.ncbi.nlm.nih.gov/22012955
https://pubmed.ncbi.nlm.nih.gov/22012955
Publikováno v:
Advances in experimental medicine and biology. 701
Stem-cell transplantation to treat acute myocardial infarction (MI) is gaining importance as a minimally invasive and potent therapy to replace akinetic scar tissue by viable myocardium. Our recent studies have shown that stem-cell transplantation ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0017b8a809d65ca9361ad82823741545
https://pubmed.ncbi.nlm.nih.gov/21445785
https://pubmed.ncbi.nlm.nih.gov/21445785