Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Saraswati, Pokharel"'
Autor:
Badri Karthikeyan, Sunitha Shyam Sunder, Igor Puzanov, Scott H. Olejniczak, Saraswati Pokharel, Umesh C. Sharma
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-9 (2024)
Abstract Background Chimeric antigen receptor (CAR) T-cell therapy and bispecific T-cell engagers, which redirect T-cells to tumor antigens, have immensely benefitted patients with relapsed/refractory B-cell cancers. How these therapies differ in car
Externí odkaz:
https://doaj.org/article/56f2e0ed07d04888b6e7bdf82f0b550f
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-27 (2023)
Abstract Since their invention in the early 2000s, tyrosine kinase inhibitors (TKIs) have gained prominence as the most effective pathway-directed anti-cancer agents. TKIs have shown significant utility in the treatment of multiple hematological mali
Externí odkaz:
https://doaj.org/article/1b2da78a4cc9482e802043c99ffdca12
Autor:
Tatiana Shaurova, Lingyue Yan, Yafei Su, Laurie James Rich, Vui King Vincent‐Chong, Hannah Calkins, Saraswati Pokharel, Martin Petkovich, Mukund Seshadri, Yun Wu, Pamela Anne Hershberger
Publikováno v:
Cancer Communications, Vol 43, Iss 4, Pp 503-507 (2023)
Externí odkaz:
https://doaj.org/article/4c6eb2db26ac4ab8ba970459644a9b28
Autor:
Meer R. Zafar, Ashutosh Sharma, Sunitha Shyam Sunder, Badri Karthikeyan, Makoto Nagahama, Andrew Atia, Ronak Bahuva, Saraswati Pokharel, Vijay Iyer, Sharma Kattel, Umesh C. Sharma
Publikováno v:
Cardio-Oncology, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Background Cancer survivors with prior chest radiation therapy (CXRT) frequently present with atrial fibrillation, heart failure, and have higher overall long-term mortality. There are no data examining the utility of left atrial (LA) and LA
Externí odkaz:
https://doaj.org/article/8e9bedab80e74a8b9bff3320ecc4406c
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Objectives Radiation emergencies are rare but can have minor confined effects to catastrophic consequences across the large geographical territories. Geographical disparities in the preparedness for radiation emergencies can negatively impact public-
Externí odkaz:
https://doaj.org/article/4e1422480c4645e6a10cb8ecce41f9dd
Autor:
Abhinay Reddy, Vasvi Singh, Badri Karthikeyan, Leyi Jiang, Silva Kristo, Sharma Kattel, Ram Amuthan, Saraswati Pokharel, Umesh C. Sharma
Publikováno v:
Cardiogenetics, Vol 11, Iss 3, Pp 98-110 (2021)
Cardiac amyloidosis (CA) is a common and potentially fatal infiltrative cardiomyopathy. Contrast-enhanced cardiac MRI (CMR) is used as a diagnostic tool. However, utility of CMR for the comprehensive analysis of biventricular strains and strain rates
Externí odkaz:
https://doaj.org/article/826bfc9fb13a49d0a59dea106e7a7231
Autor:
Swati D. Sonkawade, Shirley Xu, Minhyung Kim, Sarmila Nepali, Victoire-Grace Karambizi, Sandra Sexton, Steven G. Turowski, Kunpeng Li, Joseph A. Spernyak, Jonathan F. Lovell, Anthony George, Sujit Suwal, Umesh C. Sharma, Saraswati Pokharel
Publikováno v:
Cells, Vol 12, Iss 12, p 1589 (2023)
Background: Cardioprotective effects of N-acetyl-ser-asp-lys-pro (Ac-SDKP) have been reported in preclinical models of myocardial remodeling. However, the rapid degradation of this endogenous peptide in vivo limits its clinical use. Method: To prolon
Externí odkaz:
https://doaj.org/article/5d1e6d7baa66477393818bb394aeef47
Autor:
Mingma D. Sherpa, Swati D. Sonkawade, Vinesh Jonnala, Saraswati Pokharel, Mahyar Khazaeli, Yan Yatsynovich, Mohamad A. Kalot, Brian R. Weil, John M. Canty, Umesh C. Sharma
Publikováno v:
Cells, Vol 12, Iss 9, p 1218 (2023)
Background: Myocardial fibrosis is a common postmortem finding among individuals with Sudden Cardiac Death (SCD). Numerous in vivo and in vitro studies have shown that increased galectin-3 (gal3) expression into the myocardium is associated with high
Externí odkaz:
https://doaj.org/article/f10e896244b946eb8ad9d678205dd228
Autor:
Nikhil Agrawal, Sharma Kattel, Sameer Waheed, Ankita Kapoor, Vasvi Singh, Ashutosh Sharma, Brian J. Page, Kristopher M. Attwood, Vijay Iyer, Saraswati Pokharel, Umesh C. Sharma
Publikováno v:
Cardio-Oncology, Vol 5, Iss 1, Pp 1-12 (2019)
Abstract Background Improved cancer survival in patients treated with thoracic ionizing radiation (XRT) has resulted in unanticipated surge of aortic stenosis. Transcatheter aortic valve replacement (TAVR) has revolutionized the management of severe
Externí odkaz:
https://doaj.org/article/b706fade07eb4764851ae59247b9627e
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Since the approval of the first immune checkpoint inhibitor (ICI) 9 years ago, ICI-therapy have revolutionized cancer treatment. Lately, antibodies blocking the interaction of programmed cell death protein (PD-1) and ligand (PD-L1) are gaining moment
Externí odkaz:
https://doaj.org/article/257d623ebd7740aca7f6caf37ab59e66