Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Saraswathy V. Nochur"'
Autor:
Howard A. Burris, Jared A. Gollob, Dinah W.Y. Sah, Akshay K. Vaishnaw, Christina Gamba-Vitalo, Saraswathy V. Nochur, Jeffrey Cehelsky, Valerie A. Clausen, Renta M. Hutabarat, Nenad Svrzikapa, Gregory Hinkle, Rachel E. Meyers, David Bumcrot, Iva Toudjarska, Amy C. Seila White, Jamie Harrop, Rick Falzone, Mrinal M. Gounder, Maria Alsina, Jeffrey R. Infante, Daniel C. Cho, Luis Paz-Ares, Glen J. Weiss, Gary K. Schwartz, Andres Cervantes, Patricia M. LoRusso, Geoffrey I. Shapiro, Josep Tabernero
Supplementary Figures PDF file - 114K, Includes sequence information on KSP and VEGF siRNAs, murine Hep3B tumor model data with ALN-VSP, ALN-VSP Phase I study design, KSP and VEGF mRNA levels in tumor cell lines and normal liver, and comparison of AL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798921fa41c39c58506772199a018c15
https://doi.org/10.1158/2159-8290.22530521
https://doi.org/10.1158/2159-8290.22530521
Autor:
Howard A. Burris, Jared A. Gollob, Dinah W.Y. Sah, Akshay K. Vaishnaw, Christina Gamba-Vitalo, Saraswathy V. Nochur, Jeffrey Cehelsky, Valerie A. Clausen, Renta M. Hutabarat, Nenad Svrzikapa, Gregory Hinkle, Rachel E. Meyers, David Bumcrot, Iva Toudjarska, Amy C. Seila White, Jamie Harrop, Rick Falzone, Mrinal M. Gounder, Maria Alsina, Jeffrey R. Infante, Daniel C. Cho, Luis Paz-Ares, Glen J. Weiss, Gary K. Schwartz, Andres Cervantes, Patricia M. LoRusso, Geoffrey I. Shapiro, Josep Tabernero
Supplementary Methods and Legends PDF file - 72K, Includes detailed methods for 5' RACE assay and DCE-MRI scans, as well as figure legends for the six supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60fded2d3b851bda5dc56f8308997f4
https://doi.org/10.1158/2159-8290.22530518
https://doi.org/10.1158/2159-8290.22530518
Autor:
Howard A. Burris, Jared A. Gollob, Dinah W.Y. Sah, Akshay K. Vaishnaw, Christina Gamba-Vitalo, Saraswathy V. Nochur, Jeffrey Cehelsky, Valerie A. Clausen, Renta M. Hutabarat, Nenad Svrzikapa, Gregory Hinkle, Rachel E. Meyers, David Bumcrot, Iva Toudjarska, Amy C. Seila White, Jamie Harrop, Rick Falzone, Mrinal M. Gounder, Maria Alsina, Jeffrey R. Infante, Daniel C. Cho, Luis Paz-Ares, Glen J. Weiss, Gary K. Schwartz, Andres Cervantes, Patricia M. LoRusso, Geoffrey I. Shapiro, Josep Tabernero
Supplementary Tables PDF file - 67K, Includes data showing effect of ALN-VSP on spleen in non-human primates, tumor response data from the Phase I trial, and safety data (including adverse events and dose-limiting toxicities) from the Phase I trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abf232c1a30a2513228f151bdf1bb65
https://doi.org/10.1158/2159-8290.22530515
https://doi.org/10.1158/2159-8290.22530515
Autor:
Jared Gollob, Verena Karsten, Brian Bettencourt, Malcolm Boyce, Akshay Vaishnaw, Joseph Chiesa, Tracy Zimmermann, Saraswathy V. Nochur, Renta Hutabarat, Amy Chan
Publikováno v:
Molecular Therapy. 25:71-78
Advancement of RNAi-based therapeutics depends on effective delivery to the site of protein synthesis. Although intravenously administered, multi-component delivery vehicles have enabled small interfering RNA (siRNA) delivery and progression into cli
Autor:
Paula Gonçalves, Susete Costelha, Jennifer L. S. Willoughby, Shannon Fishman, Dinah W.Y. Sah, Rachel Meyers, James Butler, Kallanthottathil G. Rajeev, Rene Alvarez, Qingmin Chen, Tracy Zimmermann, Brian Bettencourt, Todd Borland, June Qin, Kevin Fitzgerald, Maria João Saraiva, Muthiah Manoharan, Stuart Milstein, Amy Chan, Donald Foster, Saraswathy V. Nochur
Publikováno v:
Amyloid
ATTR amyloidosis is a systemic, debilitating and fatal disease caused by transthyretin (TTR) amyloid accumulation. RNA interference (RNAi) is a clinically validated technology that may be a promising approach to the treatment of ATTR amyloidosis. The
Autor:
Hartmut Schmidt, Jeeyoung Oh, Yesim Parman, Teresa Coelho, Byoung Joon Kim, Akshay Vaishnaw, Ole B. Suhr, Chih-Chao Yang, Scott D. Solomon, Pushkal Garg, Sunita Goyal, Ivailo Tournev, Andrew Strahs, John L. Berk, Pritesh Gandhi, Shahram Attarian, Violaine Planté-Bordeneuve, Alejandra González-Duarte, Arnt V. Kristen, William O'Riordan, Kon Ping Lin, Mitsuharu Ueda, Philip N. Hawkins, Michelle M. Mezei, Jared Gollob, Jihong Chen, David Adams, Saraswathy V. Nochur, Thomas H. Brannagan, Peter J. Dyck, Josep M. Campistol, Giuseppe Vita, Marianne T. Sweetser, Michael Polydefkis, Yoshiki Sekijima, Juan Buades
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Patisiran, an investigational RNA interference therapeutic agent, specifically inhibits hepatic synthesis of transthyretin.In this phase 3 trial, we randomly assigned patients with hereditary transthyretin amyloidosis with polyneuropathy, in a 2:1 ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94e90139b6836f8b7a776e1f046b770
http://hdl.handle.net/2445/138257
http://hdl.handle.net/2445/138257
Autor:
Joseph Chiesa, Amy Simon, Jeffrey Cehelsky, Brian Bettencourt, Kevin Fitzgerald, Valerie A. Clausen, Jessica E. Sutherland, Maria Frank-Kamenetsky, Renta Hutabarat, Jay D. Horton, JM Ritter, Timothy Mant, Svetlana Shulga-Morskaya, Verena Karsten, Malathy Munisamy, Abigail Liebow, Akshay Vaishnaw, Jared Gollob, Victor Kotelianski, Saraswathy V. Nochur
Publikováno v:
The Lancet. 383:60-68
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that loss-of-function mutations in PCSK9 result in reduced plasma LDL cholesterol and decreased risk of coronary h
Autor:
A. Plaisted, Saraswathy V. Nochur, R. De Frutos, Jared Gollob, Akshay Vaishnaw, David H. Adams, Jeffrey Cehelsky, Brian Bettencourt, R. N. Denoncourt, O. Amitay, Lindsey White, T. Coelho, Jamie Harrop, Rick Falzone
Publikováno v:
Value in Health. 18(3)
Autor:
Pierre Lozeron, Valerie A. Clausen, Joseph Chiesa, Akshay Vaishnaw, James Butler, Alfica Sehgal, Javier Perez, Elizabeth Tranter, Philip N. Hawkins, Ana Martins da Silva, Jared Gollob, Dinah W.Y. Sah, Jeffrey Cehelsky, Brian Bettencourt, Timothy Mant, Christina Gamba-Vitalo, Rene Alvarez, Kevin Fitzgerald, Ole B. Suhr, Teresa Coelho, Steve Warrington, David H. Adams, Saraswathy V. Nochur, Todd Borland, Rachel Meyers, Qingmin Chen, Malathy Munisamy, Rick Falzone, Renta Hutabarat, Mary Geissler, Jamie Harrop
Publikováno v:
The New England journal of medicine. 369(9)
BACKGROUND: Transthyretin amyloidosis is caused by the deposition of hepatocyte-derived transthyretin amyloid in peripheral nerves and the heart. A therapeutic approach mediated by RNA interference (RNAi) could reduce the production of transthyretin.
Autor:
Christina Gamba-Vitalo, Rachel Meyers, Akshay Vaishnaw, Rick Falzone, Geoffrey I. Shapiro, Maria Alsina, Josep Tabernero, David Bumcrot, Gregory Hinkle, Glen J. Weiss, Valerie A. Clausen, Jared Gollob, Ivanka Toudjarska, Patricia LoRusso, Saraswathy V. Nochur, Luis Paz-Ares, Jamie Harrop, Jeffrey Cehelsky, Dinah W.Y. Sah, Nenad Svrzikapa, Amy C. Seila White, Mrinal M. Gounder, Andrés Cervantes, Renta Hutabarat, Jeffrey R. Infante, Gary K. Schwartz, Howard A. Burris, Daniel C. Cho
Publikováno v:
Cancer discovery. 3(4)
RNA interference (RNAi) is a potent and specific mechanism for regulating gene expression. Harnessing RNAi to silence genes involved in disease holds promise for the development of a new class of therapeutics. Delivery is key to realizing the potenti