Výsledky vyhledávání - "Saraswathi Patthi"

Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel

Autor: Saraswathi Patthi, Ann F. McCue, Steven B. Ellis, Gonul Velicelebi, Daniel H. Feldman, Michael M. Harpold, Paul Brust, Susan Simerson, Azarnoush Maroufi, Mark E. Williams

Publikováno v: Science (New York, N.Y.). 257(5068)

N-type calcium channels are omega-conotoxin (omega-CgTx)-sensitive, voltage-dependent ion channels involved in the control of neurotransmitter release from neurons. Multiple subtypes of voltage-dependent calcium channel complexes exist, and it is the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea39940545c6a0913f54b476b43f8ae
https://pubmed.ncbi.nlm.nih.gov/1321501

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Characterization of growth hormone releasing factor analog expression in Saccharomyces cerevisiae

Autor: William Scot Craig, Robert Steven Siegel, Thomas F. Mowles, Saraswathi Patthi, Gregory Patrick Thill, Geneva Ruth Davis, Gonul Velicelebi, Lillian Margaret Wondrack

Publikováno v: International journal of peptide and protein research. 38(5)

An analog of growth hormone releasing factor (GRF), [Leu27]GRF(1-40)-OH, has been expressed and secreted in Saccharomyces cerevisiae under the control of the alpha-factor gene promoter and prepro sequence. A single pair of consecutive basic residues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dea790ebe137c09b7e66f185345611
https://pubmed.ncbi.nlm.nih.gov/1802859

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Hydrodynamic characterization of vasoactive intestinal peptide receptors extracted from rat lung membranes in Triton X-100 and n-octyl-beta-D-glucopyranoside

Autor: Gonul Velicelebi, Michael Akong, Saraswathi Patthi

Publikováno v: Journal of Biological Chemistry. 262:15740-15745

Rat lung membrane vasoactive intestinal peptide (VIP) receptors were covalently labeled with 125I-VIP, extracted in Triton X-100 and n-octyl-beta-D-glucopyranoside, and analyzed by gel filtration and sucrose density gradient sedimentation. The fracti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d461be201d1250853840bfb9755f5c5f
https://doi.org/10.1016/s0021-9258(18)47790-3

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Covalent Cross-Linking of Growth Hormone-Releasing Factor to Pituitary Receptors

Autor: Michael Akong, Gonul Velicelebi, Sally Provow, Saraswathi Patthi

Publikováno v: Endocrinology. 118:1278-1283

We have used a bifunctional cross-linker, disuccinimidyl suberate, to covalently attach [125I]human pancreatic GH-releasing factor (GHRF) (-1-40)OH to bovine pituitary membranes and rat anterior pituitary cells. Covalently radiolabeled membrane and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fe1259d12351bd30f4712904602b1e
https://doi.org/10.1210/endo-118-4-1278

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Solubilization of rat lung vasoactive intestinal peptide receptors in the active state. Characterization of the binding properties and comparison with membrane-bound receptors

Autor: Susan Simerson, Gonul Velicelebi, Saraswathi Patthi

Publikováno v: Journal of Biological Chemistry. 263:19363-19369

We demonstrate here that rat lung membrane vasoactive intestinal peptide (VIP) receptors can be extracted in the active state using digitonin. Sepharose 4B gel filtration chromatography was utilized to demonstrate the formation of specific binding co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae18337969b6140df75f232e4e20a17c
https://doi.org/10.1016/s0021-9258(19)77642-x

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Structural Characterization of Vasoactive Intestinal Peptide Receptors from Rat Lung Membranes

Autor: Michael Akong, Sally Provow, Gonul Velicelebi, Saraswathi Patthi, Susan Simerson

Publikováno v: Annals of the New York Academy of Sciences. 527:266-281

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eeeb393d930a49ce4ab856289c1a883
https://doi.org/10.1111/j.1749-6632.1988.tb26986.x

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Design, Synthesis, and Analysis of Secondary Structure Based Vasoactive Intestinal Peptide Analogues

Autor: Saraswathi Patthi, Gönül Veliçlelebi, Gary Fred Musso, Sally Provow, Thomas C. Ryskamp

Publikováno v: Annals of the New York Academy of Sciences. 527:660-662

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::089d5e22d309cb460300273abb89762f
https://doi.org/10.1111/j.1749-6632.1988.tb27035.x

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Development of helix-based vasoactive intestinal peptide analogues: identification of residues required for receptor interaction

Autor: Gary Fred Musso, Emil Thomas Kaiser, Sally Provow, Thomas C. Ryskamp, Saraswathi Patthi, Gonul Velicelebi

Publikováno v: Biochemistry. 27(21)

Several VIP analogues have been designed on the basis of the hypothesis that the region from residue 6 to residue 28 forms a pi-helical structure when bound to membrane receptors. An empirical approach for the design and construction of analogues bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3802d3b91cc3676a691554ccc4f024b1
https://pubmed.ncbi.nlm.nih.gov/2852954

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