Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Saraswathi Naravula"'
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
Supplementary tables listing the affinities and bioactivities of MK-4166 and DTA-1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249f3473bfc76fc6a9343fe15e701207
https://doi.org/10.1158/0008-5472.22414407.v1
https://doi.org/10.1158/0008-5472.22414407.v1
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
This file contains supplementary methods that describe the antibodies used, the generation and characterization of MK-4166, various cell-based assays, and the evaluation of toxicity in cynomolgus monkeys.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69827d21a8c9e0175677d7a8489838f7
https://doi.org/10.1158/0008-5472.22414410.v1
https://doi.org/10.1158/0008-5472.22414410.v1
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
GITR is a T-cell costimulatory receptor that enhances cellular and humoral immunity. The agonist anti-mouse GITR antibody DTA-1 has demonstrated efficacy in murine models of cancer primarily by attenuation of Treg-mediated immune suppression, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bfee5aa1afeba34ec05f3cba4f5fee8
https://doi.org/10.1158/0008-5472.c.6508965.v1
https://doi.org/10.1158/0008-5472.c.6508965.v1
Autor:
Svetlana Sadekova, Amy M. Beebe, Aarron Willingham, Terrill K. McClanahan, Danuta Herzyk, Wendy J. Bailey, Venkataraman Sriram, Elaine M. Pinheiro, Denise Manfra, Peter Georgiev, Ruban Mangadu, Tatyana Churakova, Jeff Grein, Antoaneta S. Necheva, Bhagyashree Bhagwat, Romina Riener, Grigori Ermakov, Saraswathi Naravula, Jerelyn Wong, Ying Yu, Douglas C. Wilson, Selvakumar Sukumar
Supplementary Figure S1 shows the gating scheme and markers used to phenotype various T cell subsets in human blood. Supplementary Figure S2 shows the expression of GITR on human and cynomolgus monkey NK cells and T cells. Supplementary Figure S3 sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b1719210763f1f05971391ff03d06a
https://doi.org/10.1158/0008-5472.22414413.v1
https://doi.org/10.1158/0008-5472.22414413.v1
Autor:
Wendy J. Bailey, Aarron T. Willingham, Denise Manfra, Venkataraman Sriram, Elaine M. Pinheiro, Peter Georgiev, Svetlana Sadekova, Romina Riener, Selvakumar Sukumar, Jerelyn Wong, Danuta Herzyk, Grigori Ermakov, Saraswathi Naravula, Jeff Grein, Antoaneta S. Necheva, Ruban Mangadu, Terrill K. McClanahan, Bhagyashree Bhagwat, Douglas C. Wilson, Amy M Beebe, Tatyana Churakova, Ying Yu
Publikováno v:
Cancer research. 77(16)
GITR is a T-cell costimulatory receptor that enhances cellular and humoral immunity. The agonist anti-mouse GITR antibody DTA-1 has demonstrated efficacy in murine models of cancer primarily by attenuation of Treg-mediated immune suppression, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec6303e891b97af440d6928a7eb5f30
https://pubmed.ncbi.nlm.nih.gov/28611044
https://pubmed.ncbi.nlm.nih.gov/28611044
Autor:
Gulesi Ayanoglu, Erin Murphy, Scott P. Turner, Amy M Beebe, Ivan H. Chan, John B. Mumm, Venkataraman Sriram, Xueqing Zhang, Catherine Sheppard, Jeff Grein, Beth Basham, Martin Oft, Satya Medicherla, Jan Emmerich, Melanie A. Kleinschek, Lingling Wu, Michael Judo, Steven J. Blaisdell, Terrill K. McClanahan, Susan Cannon-Carlson, John L. Langowski, Danling Gu, Kyu Hong, Wolfgang Seghezzi, Smita Mauze, Brittany C. Paporello, Bela Desai, Saraswathi Naravula, Jie Dai, Drake LaFace, Collette M. Cutler
Publikováno v:
Cancer Cell. 20(6):781-796
Summary Tumor immune surveillance and cancer immunotherapies are thought to depend on the intratumoral infiltration of activated CD8 + T cells. Intratumoral CD8 + T cells are rare and lack activity. IL-10 is thought to contribute to the underlying im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be7a3a8453fea6fe1ae6913680436ca