Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Sarasija Naini"'
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Data from Inhibition of the Notch-Hey1 Axis Blocks Embryonal Rhabdomyosarcoma Tumorigenesis
Autor: Corinne M. Linardic, Rex C. Bentley, Sarasija Naini, Brian C. Belyea
Purpose: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and remains refractory to combined-modality therapy in patients with high risk disease. In skeletal myogenesis, Notch signaling prevents muscle differentiation and pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78fa3f13df6dcd86b5dc85f85132363
https://doi.org/10.1158/1078-0432.c.6519921
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6
Data from Defining the Cooperative Genetic Changes That Temporally Drive Alveolar Rhabdomyosarcoma
Autor: Corinne M. Linardic, Christopher M. Counter, Rex C. Bentley, Stephen J. Qualman, Stacey J. Adam, Katherine T. Etheridge, Sarasija Naini
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence. Despite advances in therapy, patients with a histologic variant of RMS known as alveolar (aRMS) have a 5-year survival rate of MYCN, stabilization of telomere
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e607662819785954032642b38ba69d7e
https://doi.org/10.1158/0008-5472.c.6497705
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7
A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor
Autor: Robert Blue, Christopher A. LeClair, Marta Filizola, Craig J. Thomas, Mariana Babayeva, Won-Seok Choi, Mark A. Nedelman, Amanda Weil Harrington, Sarasija Naini, Elisabetta Volpi, Jian-kang Jiang, Min Shen, Joseph Fernandez, Andrea Negri, Wenwei Huang, Jihong Li, George A. David, Joshua G. McCoy, Barry S. Coller
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:1148-1153
A collection of αIIbβ3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents’ structure-activity relationships, binding modality, and pharmacokinetic and pharmac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf46f8bf19a934abc340a37e8f64cb0
https://doi.org/10.1016/j.bmcl.2013.12.122
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8
Structure-based virtual screening of small-molecule antagonists of platelet integrin αIIbβ3 that do not prime the receptor to bind ligand
Autor: Marta Filizola, Barry S. Coller, Sarasija Naini, Jihong Li, Andrea Negri
Publikováno v: Journal of Computer-Aided Molecular Design. 26:1005-1015
Integrin αIIbβ3 has emerged as an important therapeutic target for thrombotic vascular diseases owing to its pivotal role in mediating platelet aggregation through interaction with adhesive ligands. In the search for effective anti-thrombotic agent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64da9578de942cfa23e4c8750b4dc460
https://doi.org/10.1007/s10822-012-9594-6
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9
Defining the Cooperative Genetic Changes That Temporally Drive Alveolar Rhabdomyosarcoma
Autor: Rex C. Bentley, Stephen J. Qualman, Christopher M. Counter, Corinne M. Linardic, Stacey J. Adam, Katherine T. Etheridge, Sarasija Naini
Publikováno v: Cancer Research. 68:9583-9588
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence. Despite advances in therapy, patients with a histologic variant of RMS known as alveolar (aRMS) have a 5-year survival rate of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012fdd48b99da7ce743d51b7bea93394
https://doi.org/10.1158/0008-5472.can-07-6178
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Plný text Recenzováno Digitální knihovna AV ČR
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