Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sarasa A. Mohammadi"'
Autor:
Julian M. Peiser-Oliver, Sally Evans, David J. Adams, Macdonald J. Christie, Robert J. Vandenberg, Sarasa A. Mohammadi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Animal models of human pain conditions allow for detailed interrogation of known and hypothesized mechanisms of pain physiology in awake, behaving organisms. The importance of the glycinergic system for pain modulation is well known; however, manipul
Externí odkaz:
https://doaj.org/article/c3ca73d482d34830a4a199a9a18e28de
Publikováno v:
Toxins, Vol 7, Iss 10, Pp 3916-3932 (2015)
The α9α10-nicotinic acetylcholine receptor (nAChR) has been implicated in pain and has been proposed to be a novel target for analgesics. However, the evidence to support the involvement of the α9α10-nAChR in pain is conflicted. This receptor was
Externí odkaz:
https://doaj.org/article/4a2b4f3907b44d63aae91905eebd3fc4
Autor:
Bruce S. Wilson, Julian Peiser-Oliver, Alexander Gillis, Sally Evans, Claudia Alamein, Shannon N. Mostyn, Susan Shimmon, Tristan Rawling, MacDonald J. Christie, Robert J. Vandenberg, Sarasa A. Mohammadi
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 382:246-255
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc572652ceaa23eba5bd936851645f9b
https://doi.org/10.1124/jpet.122.001265
https://doi.org/10.1124/jpet.122.001265
Autor:
Paul F. Alewood, Eamonn Kelly, Katy J. Sutcliffe, Christophe Mallet, Andrew M. Piggott, Alexander Gillis, Paramjit Singh, Ranjala Ratnayake, Sarasa A. Mohammadi, Ernest Lacey, MacDonald J. Christie, Frank Fontaine, Richard B. Sessions, Meritxell Canals, Yan P. Du, Anna M. Wang, Setareh Sianati, Robert J. Capon, Zoltan Dekan, Arsalan Yousuf, Ai-Hua Jin, Michael Stewart
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Dekan, Z, Sianati, S, Yousuf, A, Sutcliffe, K, Gillis, A, Mallet, C, Singh, P, Jin, A, Wang, A, Mohammadi, S, Stewart, M, Ratnayake, R, Fontaine, F, Lacey, E, Piggott, A, Du, Y, Canals, M, Sessions, R B, Kelly, E P, Capon, R, Alewood, P & Christie, M J 2019, ' A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 44, pp. 22353-22358 . https://doi.org/10.1073/pnas.1908662116
Dekan, Z, Sianati, S, Yousuf, A, Sutcliffe, K, Gillis, A, Mallet, C, Singh, P, Jin, A, Wang, A, Mohammadi, S, Stewart, M, Ratnayake, R, Fontaine, F, Lacey, E, Piggott, A, Du, Y, Canals, M, Sessions, R B, Kelly, E P, Capon, R, Alewood, P & Christie, M J 2019, ' A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 44, pp. 22353-22358 . https://doi.org/10.1073/pnas.1908662116
Significance Agonists of the μ-opioid receptor (MOPr) are currently the gold standard for pain treatment. However, their therapeutic usage is greatly limited by side effects including respiratory depression, constipation, tolerance, and dependence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d4d03fed007f2a4d12033bcdb9f177
http://europepmc.org/articles/PMC6825270
http://europepmc.org/articles/PMC6825270
Autor:
Tristan Rawling, Shannon N. Mostyn, Susan Shimmon, Bruce Wilson, Sarasa A. Mohammadi, Claudia Alamein, Robert J. Vandenberg, MacDonald J. Christie
Background and Purpose: Chronic pain is poorly managed by the limited treatment options currently available that act through a narrow range of mechanisms. The glycinergic system is fundamental in pain chronification and inhibiting glycine transporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::711816a628858c0cd40b448854d2ce34
https://doi.org/10.22541/au.159665030.05958468
https://doi.org/10.22541/au.159665030.05958468
Publikováno v:
Behavioural Brain Research. 328:105-114
The α9α10-subtype of nicotinic acetylcholine receptor (nAChR) has recently garnered interest in biomedicine and is being pursued as an analgesic target. However, the receptor exhibits diverse tissue distribution, the function of which is known to v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c97b07141aabcc450f32e3c26ad8a5
https://doi.org/10.1016/j.bbr.2017.04.005
https://doi.org/10.1016/j.bbr.2017.04.005
Autor:
Subhodeep Sarker, Tristan Rawling, Irina Vetter, Zachary J. Frangos, Arsalan Yousuf, MacDonald J. Christie, Renae M. Ryan, Susan Shimmon, Robert J. Vandenberg, Sarasa A. Mohammadi, Shannon N. Mostyn
© 2019 American Chemical Society. Inhibitors that target the glycine transporter 2, GlyT2, show promise as analgesics, but may be limited by their toxicity through complete or irreversible binding. Acyl-glycine inhibitors, however, are selective for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1847822f8fceca97335d7ae971b592
https://europepmc.org/articles/PMC6420064/
https://europepmc.org/articles/PMC6420064/
Autor:
Richard J. Lewis, Paul F. Alewood, MacDonald J. Christie, Sarasa A. Mohammadi, Swetha S. Murali, Ian A. Napier
Publikováno v:
Journal of Neurophysiology. 113:1511-1519
Changes in ion channel function and expression are characteristic of neuropathic pain. Voltage-gated calcium channels (VGCCs) are integral for neurotransmission and membrane excitability, but relatively little is known about changes in their expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234c199956fe27b70f9cf0e057436942
https://doi.org/10.1152/jn.00608.2014
https://doi.org/10.1152/jn.00608.2014
Publikováno v:
Scientific Reports
The development of neuropathic pain involves persistent changes in signalling within pain pathways. Reduced inhibitory signalling in the spinal cord following nerve-injury has been used to explain sensory signs of neuropathic pain but specific circui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1904ec97750ed264c5ed2f253705efbd
https://pubmed.ncbi.nlm.nih.gov/27841371
https://pubmed.ncbi.nlm.nih.gov/27841371
Publikováno v:
Journal of Neurophysiology. 107:649-657
Dysfunction at glutamatergic synapses has been proposed as a mechanism in the development of neuropathic pain. Here we sought to determine whether peripheral nerve injury-induced neuropathic pain results in functional changes to primary afferent syna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60615ae71ea8e70e3e5d6874972b3db8
https://doi.org/10.1152/jn.00763.2011
https://doi.org/10.1152/jn.00763.2011