Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Saranya Santhosh Kumar"'
Autor:
David Butler, Jeannie Hwang, Candice Estick, Akiko Nishiyama, Saranya Santhosh Kumar, Clive Baveghems, Hollie B Young-Oxendine, Meagan L Wisniewski, Ana Charalambides, Ben A Bahr
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20501 (2011)
Alzheimer's disease (AD) is an age-related neurodegenerative pathology in which defects in proteolytic clearance of amyloid β peptide (Aβ) likely contribute to the progressive nature of the disorder. Lysosomal proteases of the cathepsin family exhi
Externí odkaz:
https://doaj.org/article/dd7979c82b8c4ae38431d229954c1379
Autor:
Saranya Santhosh Kumar, Hannah Chi, Milos S. Simic, Phillip A. Frankino, Corinne Pender, Nupur Savalia, Erica A. Moehle, Ryo Higuchi-Sanabria, Andrew Dillin, Larry Joe, Brant Michael Webster, Naame Kelet, Robert T. Schinzel, Raz Bar-Ziv, Ngoc-Tram Nguyen, Jenni Durieux, Ophir Shalem
Publikováno v:
Cell. 179(6)
Summary Cells have evolved complex mechanisms to maintain protein homeostasis, such as the UPRER, which are strongly associated with several diseases and the aging process. We performed a whole-genome CRISPR-based knockout (KO) screen to identify gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a74bc95c5b6464281d7428b8b96b3d0
https://pubmed.ncbi.nlm.nih.gov/31801059
https://pubmed.ncbi.nlm.nih.gov/31801059
Autor:
Saranya Santhosh Kumar, Stephanie E. Sansbury, Jorge Henao-Mejia, Ophir Shalem, Yevgeniy V. Serebrenik
Publikováno v:
Genome research. 29(8)
Genome editing tools have simplified the generation of knock-in gene fusions, yet the prevalent use of gene-specific homology-directed repair (HDR) templates still hinders scalability. Consequently, realization of large-scale gene tagging requires fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07acfa01bb80312f23f609e2464952c8
https://pubmed.ncbi.nlm.nih.gov/31239279
https://pubmed.ncbi.nlm.nih.gov/31239279
Autor:
Yevgeniy V Serebrenik, Stephanie E Sansbury, Saranya Santhosh Kumar, Jorge Henao-Mejia, Ophir Shalem
Genome editing tools have simplified the generation of knock-in gene fusions, yet the requirement for gene-specific homology directed repair (HDR) templates still hinders the scalability of most approaches. Here, we combine intron-based protein trapp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ddf70a98cd91601830e99cecc4685e
https://doi.org/10.1101/412445
https://doi.org/10.1101/412445
Publikováno v:
Stem Cells. 30:1852-1862
Human embryonic stem cell-derived neuronal progenitors (hNPs) provide a potential source for cellular replacement following neurodegenerative diseases. One of the greatest challenges for future neuron replacement therapies will be to control extensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582e471ae1d164812e52043d36417705
https://doi.org/10.1002/stem.1162
https://doi.org/10.1002/stem.1162
Autor:
Jeannie Hwang, Clive L. Baveghems, Ben A. Bahr, Meagan L. Wisniewski, Akiko Nishiyama, Ana Charalambides, Hollie B. Young-Oxendine, Candice Estick, Saranya Santhosh Kumar, David Butler
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20501 (2011)
PLoS ONE
PLoS ONE
Alzheimer's disease (AD) is an age-related neurodegenerative pathology in which defects in proteolytic clearance of amyloid β peptide (Aβ) likely contribute to the progressive nature of the disorder. Lysosomal proteases of the cathepsin family exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa2095401a0b361925d4c5693fdcf71
http://europepmc.org/articles/PMC3112200?pdf=render
http://europepmc.org/articles/PMC3112200?pdf=render
Publikováno v:
Neuron. (6):1149-1156
SummaryMature messenger RNAs (mRNAs) consist of coding sequence (CDS) and 5′ and 3′ UTRs, typically expected to show similar abundance within a given neuron. Examining mRNA from defined neurons, we unexpectedly show extremely common unbalanced ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b35236ed92843c43c9375933581afcc