Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Sarantos Kostidis"'
Autor:
Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-23 (2024)
Abstract Background The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm. However, TDP-43 gain of function in the cytoplasm is still poorly understood since TDP-43 animal models re
Externí odkaz:
https://doaj.org/article/3a903ab063944d74afd22278e76a4d88
Autor:
Marlon J. A. de Haan, Marleen E. Jacobs, Franca M. R. Witjas, Annemarie M. A. de Graaf, Elena Sánchez-López, Sarantos Kostidis, Martin Giera, Francisco Calderon Novoa, Tunpang Chu, Markus Selzner, Mehdi Maanaoui, Dorottya K. de Vries, Jesper Kers, Ian P. J. Alwayn, Cees van Kooten, Bram Heijs, Gangqi Wang, Marten A. Engelse, Ton J. Rabelink
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The growing disparity between the demand for transplants and the available donor supply, coupled with an aging donor population and increasing prevalence of chronic diseases, highlights the urgent need for the development of platforms enabli
Externí odkaz:
https://doaj.org/article/eeb05a48024a487b97f487db593e8854
Autor:
Sander de Kivit, Mark Mensink, Sarantos Kostidis, Rico J.E. Derks, Esther A. Zaal, Marieke Heijink, Lotte J. Verleng, Evert de Vries, Ellen Schrama, Niek Blomberg, Celia R. Berkers, Martin Giera, Jannie Borst
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114681- (2024)
Summary: Regulatory T cells (Tregs) suppress pro-inflammatory conventional T cell (Tconv) responses. As lipids impact cell signaling and function, we compare the lipid composition of CD4+ thymus-derived (t)Tregs and Tconvs. Lipidomics reveal constitu
Externí odkaz:
https://doaj.org/article/de51d349abac4044b71dadce296bbfdb
Autor:
Anaísa V. Ferreira, Juan Carlos Alarcon-Barrera, Jorge Domínguez-Andrés, Özlem Bulut, Gizem Kilic, Priya A. Debisarun, Rutger J. Röring, Hatice N. Özhan, Eva Terschlüsen, Athanasios Ziogas, Sarantos Kostidis, Yassene Mohammed, Vasiliki Matzaraki, George Renieris, Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea, Martin Giera
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Infections and vaccines can induce enhanced long-term responses in innate immune cells, establishing an innate immunological memory termed trained immunity. Here, we show that monocytes with a trained immunity phenotype, due to exposure to t
Externí odkaz:
https://doaj.org/article/8d55ada0d53e44d18afec045e805fbf3
Autor:
Iosifina P. Foskolou, Pedro P. Cunha, Elena Sánchez-López, Eleanor A. Minogue, Benoît P. Nicolet, Aurélie Guislain, Christian Jorgensen, Sarantos Kostidis, Nordin D. Zandhuis, Laura Barbieri, David Bargiela, Demitris Nathanael, Petros A. Tyrakis, Asis Palazon, Martin Giera, Monika C. Wolkers, Randall S. Johnson
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113013- (2023)
Summary: 2-Hydroxyglutarate (2HG) is a byproduct of the tricarboxylic acid (TCA) cycle and is readily detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S-2HG and R-2HG. Here, we investigate the differential roles
Externí odkaz:
https://doaj.org/article/8bf56a3c50134fed9555ff2704dda5a3
Autor:
Anaísa V. Ferreira, Sarantos Kostidis, Laszlo A. Groh, Valerie A.C.M. Koeken, Mariolina Bruno, Ilayda Baydemir, Gizem Kilic, Özlem Bulut, Theano Andriopoulou, Victoria Spanou, Kalliopi D. Synodinou, Theologia Gkavogianni, Simone J.C.F.M. Moorlag, L. Charlotte de Bree, Vera P. Mourits, Vasiliki Matzaraki, Werner J.H. Koopman, Frank L. van de Veerdonk, Georgios Renieris, Martin Giera, Evangelos J. Giamarellos-Bourboulis, Boris Novakovic, Jorge Domínguez-Andrés
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112658- (2023)
Summary: Itaconate is an immunomodulatory metabolite produced by immune cells under microbial stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti-inflammatory responses. We show that dimethyl itaconate, a derivative
Externí odkaz:
https://doaj.org/article/6e7649ccdf4846afb0796f373689a5d6
Autor:
Zhuang Li, Enchen Zhou, Cong Liu, Hope Wicks, Sena Yildiz, Farhana Razack, Zhixiong Ying, Sander Kooijman, Debby P.Y. Koonen, Marieke Heijink, Sarantos Kostidis, Martin Giera, Ingrid M.J.G. Sanders, Ed J. Kuijper, Wiep Klaas Smits, Ko Willems van Dijk, Patrick C.N. Rensen, Yanan Wang
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Short-chain fatty acids, including butyrate, have multiple metabolic benefits in individuals who are lean but not in individuals with metabolic syndrome, with the underlying mechanisms still being unclear. We aimed to investigate the role of gut micr
Externí odkaz:
https://doaj.org/article/6c025fae6dd54893bb58c72dea373113
Autor:
Saeed Katiraei, Janna A. van Diepen, Luciana P. Tavares, Lisa R. Hoving, Amanda Pronk, Ineke Verschueren, Patrick C. N. Rensen, Jaap Jan Zwaginga, Sarantos Kostidis, Martin Giera, Mauro Teixera, Ko Willems van Dijk, Mihai G. Netea, Jimmy F. P. Berbée, Vanessa van Harmelen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Bone marrow transplantation (BMT) involves conditioning regimens which acutely induce side effects, including systemic inflammation, intestinal damage and shifts in the gut microbial composition, some of which may persist chronically. As the
Externí odkaz:
https://doaj.org/article/cc4da25ea14d4d3fafb29c84e5ac24db
Publikováno v:
Metabolites, Vol 13, Iss 7, p 875 (2023)
The poor availability of oxygen and nutrients in malignant tumors drives the activation of various molecular responses and metabolic reprogramming in cancer cells. Hypoxic tumor regions often exhibit resistance to chemotherapy and radiotherapy. One a
Externí odkaz:
https://doaj.org/article/6c7c673a1ce84b9aa1faaeb37fd7c746
Autor:
Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis, Thomas Carell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is red
Externí odkaz:
https://doaj.org/article/135f870c99dd4995a292de8aef187119