Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sarah-Anne E Nicholas"'
Autor:
John B Lees-Shepard, Sarah-Anne E Nicholas, Sean J Stoessel, Parvathi M Devarakonda, Michael J Schneider, Masakazu Yamamoto, David J Goldhamer
Publikováno v:
eLife, Vol 7 (2018)
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by debilitating heterotopic ossification (HO). The retinoic acid receptor gamma agonist, palovarotene, and antibody-mediated activin A blockade have entered human cl
Externí odkaz:
https://doaj.org/article/a67397fb4bc442cf9f3548431a220bd8
Autor:
John B. Lees-Shepard, Masakazu Yamamoto, Arpita A. Biswas, Sean J. Stoessel, Sarah-Anne E. Nicholas, Cathy A. Cogswell, Parvathi M. Devarakonda, Michael J. Schneider, Samantha M. Cummins, Nicholas P. Legendre, Shoko Yamamoto, Vesa Kaartinen, Jeffrey W. Hunter, David J. Goldhamer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Fibrodysplasia ossificans progressiva is a severe disorder characterized by heterotopic ossification, and is caused by mutations in ACVR1. Here, the authors show that expression of mutant ACVR1 in fibro/adipogenic progenitors recapitulates disease pr
Externí odkaz:
https://doaj.org/article/cce620ded4304ad1a71c991a24918aac
Autor:
Jessica A. Hensel, Sarah-Anne E. Nicholas, Amy L. Kimble, Arjun S. Nagpal, Omar M. F. Omar, Jordan D. Tyburski, Evan R. Jellison, Antoine Ménoret, Manabu Ozawa, Annabelle Rodriguez-Oquendo, Anthony T. Vella, Patrick A. Murphy
Publikováno v:
Proceedings of the National Academy of Sciences. 119
NF-κB–mediated endothelial activation drives leukocyte recruitment and atherosclerosis, in part through adhesion molecules Icam1 and Vcam1. The endothelium is primed for cytokine activation of NF-κB by exposure to low and disturbed blood flow (LD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97bf976c1356c50f332f34fbb540c72
https://doi.org/10.1073/pnas.2122227119
https://doi.org/10.1073/pnas.2122227119
Autor:
Amy L. Kimble, Manabu Ozawa, Evan R. Jellison, Patrick A. Murphy, Antoine Ménoret, Jessica A. Hensel, Anthony T. Vella, Sarah-Anne E. Nicholas, Annabelle Rodriguez-Oquendo
NFκB mediated endothelial activation drives leukocyte recruitment and atherosclerosis, in part through upregulation of adhesion molecules Icam1 and Vcam. The endothelium is “primed” for cytokine activation of NFκB by exposure to low and disturb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1b0ce40b0de4cb631acd9f8bc6e114f
https://doi.org/10.1101/2021.06.18.449062
https://doi.org/10.1101/2021.06.18.449062
Autor:
Amy L. Kimble, Sarah-Anne E. Nicholas, Jessica A. Hensel, Melissa Murphy, Jordan Silva, Patrick A. Murphy, Evan R. Jellison, Bo Reese
Endothelial cells are important contributors to brain development, physiology, and disease. Although RNA sequencing has contributed to the understanding of brain endothelial cell diversity, bulk analysis and single-cell approaches have relied on fres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2386223be3a2e669aed77b77be0212db
https://doi.org/10.1101/2021.05.12.443932
https://doi.org/10.1101/2021.05.12.443932
Autor:
Amanda M. Del Rosario, Patrick A. Murphy, Noor Jailkhani, Sarah-Anne E. Nicholas, Richard O. Hynes, Amy L. Kimble, Jeremy L. Balsbaugh, Shahinoor Begum
Publikováno v:
Prof. Richard Hynes
Arterioscler Thromb Vasc Biol
Arterioscler Thromb Vasc Biol
Objective: Exposure of the arterial endothelium to low and disturbed flow is a risk factor for the erosion and rupture of atherosclerotic plaques and aneurysms. Circulating and locally produced proteins are known to contribute to an altered compositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c4352c82ba070c9cedec183232f790
https://hdl.handle.net/1721.1/131166
https://hdl.handle.net/1721.1/131166
Autor:
Sebastian Günther, Antoine Ménoret, Beiyan Zhou, Annabelle Rodriguez, Sarah-Anne E. Nicholas, Anthony T. Vella, Eric J. Sundberg, Maria M. Xu, Patrick A. Murphy
Publikováno v:
Am J Physiol Heart Circ Physiol
Effector CD8 T cells infiltrate atherosclerotic lesions and are correlated with cardiovascular events, but the mechanisms regulating their recruitment and retention are not well understood. CD137 (4–1BB) is a costimulatory receptor induced on immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f424c4af4bb28c40b89aedf26ac6cbb7
https://pubmed.ncbi.nlm.nih.gov/30978132
https://pubmed.ncbi.nlm.nih.gov/30978132
Autor:
Parvathi M. Devarakonda, Sarah-Anne E. Nicholas, Sean J. Stoessel, John B Lees-Shepard, Masakazu Yamamoto, Michael J Schneider, David J. Goldhamer
Publikováno v:
eLife, Vol 7 (2018)
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by debilitating heterotopic ossification (HO). The retinoic acid receptor gamma agonist, palovarotene, and antibody-mediated activin A blockade have entered human cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b09e074a37833a54fd47482dd8cc1c
https://doi.org/10.7554/elife.40814
https://doi.org/10.7554/elife.40814
Autor:
Sarah-Anne E. Nicholas, Sean J. Stoessel, John B Lees-Shepard, Masakazu Yamamoto, David J. Goldhamer, Parvathi M. Devarakonda, Michael J Schneider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7cae85f06fd1efe08f4d57304fed9c7
https://doi.org/10.7554/elife.40814.021
https://doi.org/10.7554/elife.40814.021
Autor:
Jeffrey W. Hunter, Nicholas P. Legendre, David J. Goldhamer, Sarah Anne E. Nicholas, Masakazu Yamamoto, Michael J Schneider, Arpita A. Biswas, Samantha M. Cummins, Sean J. Stoessel, John B Lees-Shepard, Shoko Yamamoto, Cathy A. Cogswell, Vesa Kaartinen, Parvathi M. Devarakonda
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder characterized by progressive and profoundly disabling heterotopic ossification (HO). Here we show that fibro/adipogenic progenitors (FAPs) are a major cell-of-origin of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7492bcdb795aaa02d1efcd6ee5a91e12
http://europepmc.org/articles/PMC5797136
http://europepmc.org/articles/PMC5797136