Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sarah di Somma"'
Autor:
Maria Rosaria Ambrosio, Teresa Migliaccio, Fabiana Napolitano, Sarah Di Somma, Giovanni Maneli, Jussara Amato, Bruno Pagano, Antonio Randazzo, Giuseppe Portella, Pietro Formisano, Anna Maria Malfitano
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background G-quadruplex (G4) motifs are nucleic acid secondary structures observed in mammalian genomes and transcriptomes able to regulate various cellular processes. Several small molecules have been developed so far to modulate G4 stabili
Externí odkaz:
https://doaj.org/article/61e379bd56254b75b0a1446cbd630233
Autor:
Michele Cennamo, Evelina La Civita, Laura Sarno, Gianluigi Carbone, Sarah Di Somma, Serena Cabaro, Jacopo Troisi, Angelo Sirico, Francesco Paolo Improda, Maurizio Guida, Daniela Terracciano, Giuseppe Portella
Publikováno v:
Microorganisms, Vol 11, Iss 1, p 223 (2023)
COVID-19 is characterized by the immune system’s overreaction resulting in a ‘cytokine storm’, consisting in a massive release of cytokine into the bloodstream, leading to local and systemic inflammatory response. This clinical picture is furth
Externí odkaz:
https://doaj.org/article/995644a39db0470da3705622ae00254a
Autor:
Fabiana Napolitano, Sarah Di Somma, Giuliano Castellano, Jussara Amato, Bruno Pagano, Antonio Randazzo, Giuseppe Portella, Anna Maria Malfitano
Publikováno v:
Cells, Vol 11, Iss 16, p 2482 (2022)
G-quadruplexes (G4s) are nucleic secondary structures characterized by G-tetrads. G4 motif stabilization induces DNA damage and cancer cell death; therefore, G4-targeting small molecules are the focus of clinical investigation. DNA destabilization in
Externí odkaz:
https://doaj.org/article/4ceed773775b43fb963286e084cfc764
Autor:
Francesca Gado, Rebecca Ferrisi, Sarah Di Somma, Fabiana Napolitano, Kawthar A. Mohamed, Lesley A. Stevenson, Simona Rapposelli, Giuseppe Saccomanni, Giuseppe Portella, Roger G. Pertwee, Robert B. Laprairie, Anna Maria Malfitano, Clementina Manera
Publikováno v:
Molecules, Vol 27, Iss 9, p 3019 (2022)
1,8-naphthyridine-3-carboxamide structures were previously identified as a promising scaffold from which to obtain CB2R agonists with anticancer and anti-inflammatory activity. This work describes the synthesis and functional characterization of new
Externí odkaz:
https://doaj.org/article/101b3cbd7b224d4aafd7636fae7db135
Publikováno v:
Biomedicines, Vol 9, Iss 10, p 1309 (2021)
Cellular compartments constituting the tumor microenvironment including immune cells, fibroblasts, endothelial cells, and mesenchymal stromal/stem cells communicate with malignant cells to orchestrate a series of signals that contribute to the evolut
Externí odkaz:
https://doaj.org/article/744b67975a8445f3bd92824309f7dad9
Autor:
Sarah Di Somma, Carmelina Antonella Iannuzzi, Carmela Passaro, Iris Maria Forte, Raffaella Iannone, Vincenzo Gigantino, Paola Indovina, Gerardo Botti, Antonio Giordano, Pietro Formisano, Giuseppe Portella, Anna Maria Malfitano, Francesca Pentimalli
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure that urgently requires effective therapeutic strategies. Current treatments are unable to increase significantly patient survival, which is oft
Externí odkaz:
https://doaj.org/article/a4d30345c67a43b790c451846bd62bbb
Autor:
Maria Rosaria Galdiero, Gilda Varricchi, Stefania Loffredo, Claudio Bellevicine, Tiziana Lansione, Anne Lise Ferrara, Raffaella Iannone, Sarah di Somma, Francesco Borriello, Eduardo Clery, Maria Triassi, Giancarlo Troncone, Gianni Marone
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199740 (2018)
BACKGROUND:Neutrophil functions have long been regarded as limited to acute inflammation and the defense against microbes. The role(s) of neutrophils in cancer remain poorly understood. Neutrophils infiltrate tumors and are key effector cells in the
Externí odkaz:
https://doaj.org/article/3451eeb08b78428e91a333ea61cfb43e
Autor:
Fabiana, Napolitano, Sarah, Di Somma, Giuliano, Castellano, Jussara, Amato, Bruno, Pagano, Antonio, Randazzo, Giuseppe, Portella, Anna Maria, Malfitano
Publikováno v:
Cells. 11(16)
G-quadruplexes (G4s) are nucleic secondary structures characterized by G-tetrads. G4 motif stabilization induces DNA damage and cancer cell death; therefore, G4-targeting small molecules are the focus of clinical investigation. DNA destabilization in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da1a1b9fef23105d233b5a9121d422bf
https://pubmed.ncbi.nlm.nih.gov/36010559
https://pubmed.ncbi.nlm.nih.gov/36010559
Autor:
Adele Di Matteo, Sarah Di Somma, Anna Maria Malfitano, Paolo A. Netti, Luca Federici, Concetta Di Natale, Daniela Marasco, Daniele Florio, Giancarlo Morelli
Publikováno v:
International Journal of Biological Macromolecules. 164:3501-3507
The role exerted by the nucleus in the regulation of proteostasis in both health and disease is recognized of outmost importance, even though not fully understood. Many recent investigations are focused on its ability to modulate and coordinate prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faa737f47fb7459ada13bc819eb6d33
https://doi.org/10.1016/j.ijbiomac.2020.08.248
https://doi.org/10.1016/j.ijbiomac.2020.08.248
Autor:
Jussara Amato, Bruno Pagano, Anna Maria Malfitano, Sarah Di Somma, Giuseppe Portella, Fabiana Napolitano, Antonio Randazzo
Background: G-quadruplex (G4) are nucleic secondary structures characterized by G-tetrads. G4 motif stabilization induces DNA damage and cancer cell death; therefore, G4-targeting small molecules are the focus of clinical investigation. DNA destabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ccb2e327b0806888aab5eb25e53874f
https://doi.org/10.21203/rs.3.rs-743363/v1
https://doi.org/10.21203/rs.3.rs-743363/v1
