Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sarah Zaghouani"'
Autor:
Pratiksha I. Thakore, Alexandra Schnell, Maryann Zhao, Linglin Huang, Yu Hou, Elena Christian, Sarah Zaghouani, Chao Wang, Vasundhara Singh, Sai Ma, Venkat Sankar, Samuele Notarbartolo, Jason D. Buenrostro, Federica Sallusto, Nikolaos A. Patsopoulos, Orit Rozenblatt-Rosen, Vijay K. Kuchroo, Aviv Regev
Th17 cells are a heterogenous cell population consisting of non-pathogenic Th17 cells (npTh17) that contribute to tissue homeostasis and pathogenic Th17 cells (pTh17) that are potent mediators of tissue inflammation. To reveal regulatory mechanisms u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d169e14c7d30197d7fc92e62656609e5
https://doi.org/10.1101/2022.02.26.482041
https://doi.org/10.1101/2022.02.26.482041
Autor:
Kerry A. Pierce, Manoocher Soleimani, David DeTomaso, Lloyd Bod, Julian Avila-Pacheco, Elliot Akama-Garren, Brandon Schellhaass, Nir Yosef, Vasundhara Singh, Pratiksha I. Thakore, Allon Wagner, Sarah Zaghouani, Clary B. Clish, Raymond A. Sobel, James Kaminski, Alexandra Schnell, Erika L. Pearce, Chao Wang, Johannes Fessler, Daniel J. Puleston, Aviv Regev, Vijay K. Kuchroo, Elena Christian, Noga Ron-Harel, Vivian Paraskevi Douglas, Marcia C. Haigis
Publikováno v:
Cell
Cell, vol 184, iss 16
Cell, vol 184, iss 16
Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a516f7d904eb1d13dfbea99d5d9100ca
https://hdl.handle.net/21.11116/0000-000D-1A86-F21.11116/0000-000D-1A88-D
https://hdl.handle.net/21.11116/0000-000D-1A86-F21.11116/0000-000D-1A88-D
Autor:
Kouichiro Goto, Vijay K. Kuchroo, Manu Rangachari, Hitoshi Okada, Chao Wang, Orit Rosenblatt-Rosen, Elena Christian, Tak W. Mak, Chen Zhu, Karen O. Dixon, Kathleen Newcomer, Aviv Regev, Guangxiang Gu, Meromit Singer, Huiyuan Zhang, Markus A. Schramm, Sheng Xiao, Sarah Zaghouani
Publikováno v:
Science Advances
Tim-3 adaptor protein Bat3 regulates T cell terminal differentiation and exhaustion in an mTORC2-dependent manner.
T cell exhaustion has been associated with poor prognosis in persistent viral infection and cancer. Conversely, in the context of
T cell exhaustion has been associated with poor prognosis in persistent viral infection and cancer. Conversely, in the context of
Autor:
Aviv Regev, Nir Yosef, Johannes Fessler, Clary B. Clish, David DeTomaso, Noga Ron-Harel, Marcia C. Haigis, Raymond A. Sobel, Kerry A. Pierce, Chao Wang, Julian Avila-Pacheco, Sarah Zaghouani, Allon Wagner, Elliot Akama-Garren, Sequoia Eyzaguirre, Vijay K. Kuchroo, Vivian Paraskevi Douglas
Cellular metabolism, a key regulator of immune responses, is difficult to study with current technologies in individual cells Here, we present Compass, an algorithm to characterize the metabolic state of cells based on single-cell RNA-Seq and flux ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e9d49b551e692a9fb32be0b6f26757
https://doi.org/10.1101/2020.01.23.912717
https://doi.org/10.1101/2020.01.23.912717
Autor:
Sarah Zaghouani, Noga Ron-Harel, Julian Avila-Pacheco, Pratiksha I. Thakore, Erika L. Pearce, Nir Yosef, Ray Sobel, Kerry A. Pierce, Clary B. Clish, Lloyd Bod, Marcia C. Haigis, Daniel J. Puleston, Alexandra Schnell, David DeTomaso, Manoocher Soleimani, Chao Wang, Allon Wagner, Jim Karminski, Johannes Fessler, Vijay K. Kuchroo, Aviv Regev
Cellular metabolism can orchestrate immune cell function. We previously demonstrated that lipid biosynthesis represents one such gatekeeper to Th17 cell functional state. Utilizing Compass, a transcriptome-based algorithm for prediction of metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c6c38f7f8a3c45dc848ee75986fb65
Autor:
Allon Wagner, Chao Wang, David DeTomaso, Julian Avila Pacheco, Sarah Zaghouani, Johannes Fessler, Elliot Akama-Garren, Kerry Pierce, Noga Ron-Harel, Marcia Haigis, Raymond A Sobel, Clary Clish, Aviv Regev, Vijay K Kuchroo, Nir Yosef
Publikováno v:
The Journal of Immunology. 204:150.22-150.22
Cellular metabolism is a major regulator of immune response, but it is difficult to study the metabolic status of an individual immune cell using current technologies. Here, we present Compass, an algorithm to characterize the metabolic landscape of
Autor:
Xiaoxiao Wan, Christine M. Hoeman, Sarah Zaghouani, Amie M. VanMorlan, Jason A. Cascio, Mermagya Dhakal, F. Betul Guloglu, Habib Zaghouani, Linda M. Rowland
Publikováno v:
Diabetes
Immune modulation of pancreatic inflammation induces recovery from type 1 diabetes (T1D), but remission was not durable, perhaps because of an inability to sustain the formation and function of new pancreatic β-cells. We have previously shown that I
Autor:
Mermagya Dhakal, Sarah Zaghouani, Xiaoxiao Wan, Marie Therese Khairallah, Weirong Chen, Habib Zaghouani, Rohit D. Divekar, Linda M. Rowland, Cara L. Haymaker, Jason A. Cascio
Publikováno v:
The Journal of Immunology. 190:6004-6014
Dendritic cells (DCs) have been shown to play a major role in oral tolerance, and this function has been associated with their ability to produce anti-inflammatory cytokines and to induce suppressive regulatory T cells. In this study, we demonstrate
Autor:
Hyun-Tak Jin, Chen Zhu, Rafi Ahmed, Vijay K. Kuchroo, Chuan Wu, Thomas Pertel, Zhiyi Sun, Ana C. Anderson, Sheng Xiao, Manu Rangachari, Chao Wang, Dewar J. Tan, Kaori Sakuishi, Guangxiang Gu, Sarah Zaghouani
Publikováno v:
Nature Communications. 6
Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL–10 expression and T-cell dysfunction
Autor:
Cara L. Haymaker, Xiaoxiao Wan, Sarah Zaghouani, Christine M. Hoeman, Danielle M. Tartar, Amie M. VanMorlan, Mermagya Dhakal, Habib Zaghouani, Linda M. Rowland, John C. Hardaway, Jason A. Cascio, F. Betul Guloglu
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 188(7)
The earliest thymic progenitors (ETPs) were recently shown to give rise to both lymphoid and myeloid cells. Whereas the majority of ETPs are derived from IL-7Rα–positive cells and give rise exclusively to T cells, the origin of the myeloid cells r